scholarly journals Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line

2007 ◽  
Vol 122 (2) ◽  
pp. 298-304 ◽  
Author(s):  
Massimiliano Cariati ◽  
Ali Naderi ◽  
John P. Brown ◽  
Matthew J. Smalley ◽  
Sarah E. Pinder ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Mcf7 Breast Cancer Cell

An anticancer effect of umbilical cord-derived mesenchymal stem cell secretome on the breast cancer cell line

2019 ◽  
Vol 20 (3) ◽  
pp. 423-434 ◽  
Author(s):  
Mansoureh Mirabdollahi ◽  
Shaghayegh Haghjooyjavanmard ◽  
Hojjat Sadeghi-aliabadi
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Line ◽  
Umbilical Cord ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Anticancer Effect

47 Upregulation of the miR-515 cluster in the MCF7 breast cancer cell line by epigenetic therapy

Apmis ◽  
2008 ◽  
Vol 116 (5) ◽  
pp. 437-437
Author(s):  
C. Hother ◽  
C. Cortez ◽  
T. Miranda ◽  
C. Yoo ◽  
C. Workman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Epigenetic Therapy ◽  
Mcf7 Breast Cancer Cell

scholarly journals Antimicrobial Activity, In Vitro Anticancer Effect (MCF7 Breast Cancer Cell Line), Antiangiogenic and Immunomodulatory Potentials of Populus Nigra L. Buds Extract

2021 ◽  
Author(s):  
Brigitta Kis ◽  
Ioana Zinuca Pavel ◽  
Stefana Avram ◽  
Elena Alina Moaca ◽  
Martina Herrero San Juan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Populus Nigra ◽  
Mcf7 Breast Cancer Cell ◽  
Immunomodulatory Potential

Abstract Purpose: The aim of this study was to evaluate the antioxidant potential, antimicrobial activity, the in vitro anticancer effect (MCF7 breast cancer cell line), as well as the antiangiogenic and immunomodulatory potential of Populus nigra L. bud (Pg) extract collected from the western part of Romania.Results:Populus nigra L. bud extract presents an important antioxidant activity, due to the rich phytochemical composition. Regarding the biological activity, results have shown that poplar bud extract presents a significant inhibitory activity against Gram-positive bacteria and a dose-dependent decrease of MCF7 tumor cell viability with an IC50 of 66.26 µg/mL, while not affecting healthy cells. Phenomena of early apoptotic events at the maximum concentration tested (150 µg/mL) were detected by Annexin V-PI double staining. The extract induced G0/G1 phase cell cycle arrest. In addition, Pg extract showed antiangiogenic potential on the chorioallantoic membrane. Also, at the highest concentration (150 µg/mL), good tolerability and no signs of toxicity upon vascular plexus were observed. Moreover, in low concentrations, the Pg extract had immunomodulatory activity on primary human dendritic cells by upregulating IL-12 and IL-23 subunits.Conclusion:The study concludes that poplar bud extract elicited antioxidant activity, antitumor properties on the breast cancer cell line, followed by an antiangiogenic effect and an immunomodulatory potential on human primary dendritic cells. The biological activity of Populus nigra L. buds extract may open new directions of research on the topic addressed.

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