scholarly journals Histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin suppresses the malignant phenotype of neuroblastoma cells

2007 ◽  
Vol 122 (8) ◽  
pp. 1891-1900 ◽  
Author(s):  
Hedwig E. Deubzer ◽  
Volker Ehemann ◽  
Frank Westermann ◽  
Ralf Heinrich ◽  
Gunhild Mechtersheimer ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Neuroblastoma Cells ◽  
Malignant Phenotype ◽  
Deacetylase Inhibitor ◽  
Hc Toxin

Reprogramming of neuroblastoma cells by the histone deacetylase inhibitor valproic acid

2004 ◽  
Vol 216 (03) ◽  
Author(s):  
H Deubzer ◽  
J Schulte ◽  
L Schweigerer ◽  
J Hoheisel ◽  
O Witt
Keyword(s):  
Valproic Acid ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Neuroblastoma Cells ◽  
Deacetylase Inhibitor

Regulation of cellular processes by PPARγ ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression

2004 ◽  
Vol 32 (5) ◽  
pp. 840-842 ◽  
Author(s):  
V.C. Emmans ◽  
H.A. Rodway ◽  
A.N. Hunt ◽  
K.A. Lillycrop
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Trichostatin A ◽  
Neuroblastoma Cells ◽  
Retinoblastoma Protein ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Cellular Processes ◽  
Deacetylase Inhibitor

Neuroblastoma is a childhood cancer, which spontaneously regresses. This has led to a search for agents that mimic this process. We show that both natural and synthetic ligands of PPARγ (peroxisome-proliferator-activated receptor γ) inhibit the growth of neuroblastoma cells in vitro. The degree of PPAR activation was attenuated however in the presence of the retinoblastoma protein. Addition of trichostatin A, a histone deacetylase inhibitor, abolished retinoblastoma protein repression of PPAR activity. Moreover, enhanced growth inhibition was observed when neuroblastoma cells were treated with a PPARγ ligand and a histone deacetylase inhibitor, suggesting a combination therapy to treat neuroblastoma might prove more effective than using either agent alone.

scholarly journals Histone deacetylase inhibitor screening identifies HC toxin as the most effective in intrahepatic cholangiocarcinoma cells

2016 ◽  
Vol 35 (5) ◽  
pp. 2535-2542 ◽  
Author(s):  
WENJIE ZHOU ◽  
XIAOXUN CHEN ◽  
KE HE ◽  
JINFENG XIAO ◽  
XIAOPENG DUAN ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Intrahepatic Cholangiocarcinoma ◽  
Histone Deacetylase Inhibitor ◽  
Inhibitor Screening ◽  
Deacetylase Inhibitor ◽  
Hc Toxin

The novel histone deacetylase inhibitor BL1521 inhibits proliferation and induces apoptosis in neuroblastoma cells

2004 ◽  
Vol 68 (7) ◽  
pp. 1279-1288 ◽  
Author(s):  
Annemieke J.M. de Ruijter ◽  
Stephan Kemp ◽  
Gertjan Kramer ◽  
Rutger J. Meinsma ◽  
Judith O. Kaufmann ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Neuroblastoma Cells ◽  
The Novel ◽  
Deacetylase Inhibitor

scholarly journals Histone deacetylase inhibitor BL1521 induces a G1-phase arrest in neuroblastoma cells through altered expression of cell cycle proteins

FEBS Letters ◽  
2005 ◽  
Vol 579 (6) ◽  
pp. 1523-1528 ◽  
Author(s):  
Krista Ouwehand ◽  
Annemieke J.M. de Ruijter ◽  
Chris van Bree ◽  
Huib N. Caron ◽  
André B.P. van Kuilenburg
Keyword(s):  
Cell Cycle ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Neuroblastoma Cells ◽  
G1 Phase ◽  
Cell Cycle Proteins ◽  
Altered Expression ◽  
Phase Arrest ◽  
Deacetylase Inhibitor ◽  
G1 Phase Arrest

Antagonistic effects of sequential administration of BL1521, a histone deacetylase inhibitor, and gemcitabine to neuroblastoma cells

2006 ◽  
Vol 233 (2) ◽  
pp. 240-246 ◽  
Author(s):  
Annemieke J.M. de Ruijter ◽  
René Leen ◽  
Jerry Hoebink ◽  
Huib N. Caron ◽  
André B.P. van Kuilenburg
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Neuroblastoma Cells ◽  
Antagonistic Effects ◽  
Deacetylase Inhibitor ◽  
Sequential Administration
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