scholarly journals Detection of Merkel cell polyomavirus (MCPyV) in Merkel cell carcinoma cell lines: Cell morphology and growth phenotype do not reflect presence of the virus

2009 ◽  
pp. NA-NA ◽  
Author(s):  
Nicole Fischer ◽  
Johanna Brandner ◽  
Franca Fuchs ◽  
Ingrid Moll ◽  
Adam Grundhoff
Keyword(s):  
Cell Carcinoma ◽  
Cell Lines ◽  
Merkel Cell Carcinoma ◽  
Cell Morphology ◽  
Carcinoma Cell ◽  
Merkel Cell Polyomavirus ◽  
Merkel Cell ◽  
Carcinoma Cell Lines ◽  
Growth Phenotype

Secretomic analysis of extracellular vesicles originating from polyomavirus-negative and polyomavirus-positive Merkel cell carcinoma cell lines

PROTEOMICS ◽  
2016 ◽  
Vol 16 (19) ◽  
pp. 2587-2591 ◽  
Author(s):  
Aelita Konstantinell ◽  
Jack-Ansgar Bruun ◽  
Randi Olsen ◽  
Augusta Aspar ◽  
Nataša Škalko-Basnet ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Cell Lines ◽  
Extracellular Vesicles ◽  
Merkel Cell Carcinoma ◽  
Carcinoma Cell ◽  
Merkel Cell ◽  
Carcinoma Cell Lines

Radiation sensitivity of merkel cell carcinoma cell lines

1995 ◽  
Vol 32 (5) ◽  
pp. 1401-1407 ◽  
Author(s):  
J.Helen Leonard ◽  
Jonathan R. Ramsay ◽  
John H. Kearsley ◽  
Geoff W. Birrell
Keyword(s):  
Cell Carcinoma ◽  
Cell Lines ◽  
Merkel Cell Carcinoma ◽  
Carcinoma Cell ◽  
Radiation Sensitivity ◽  
Merkel Cell ◽  
Carcinoma Cell Lines

scholarly journals Spontaneous lung metastasis formation of human Merkel cell carcinoma cell lines transplanted into scid mice

2017 ◽  
Vol 141 (1) ◽  
pp. 160-171 ◽  
Author(s):  
Jill Knips ◽  
Manja Czech-Sioli ◽  
Michael Spohn ◽  
Max Heiland ◽  
Ingrid Moll ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Cell Lines ◽  
Merkel Cell Carcinoma ◽  
Lung Metastasis ◽  
Carcinoma Cell ◽  
Scid Mice ◽  
Merkel Cell ◽  
Metastasis Formation ◽  
Carcinoma Cell Lines

scholarly journals Inhibition of PI3K by copanlisib exerts potent antitumor effects on Merkel cell carcinoma cell lines and mouse xenografts

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Bin Fang ◽  
Aarthi Kannan ◽  
Stephanie Zhao ◽  
Quy H. Nguyen ◽  
Samuel Ejadi ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Cell Lines ◽  
Merkel Cell Carcinoma ◽  
Carcinoma Cell ◽  
Merkel Cell ◽  
Antitumor Effects ◽  
Carcinoma Cell Lines

scholarly journals Merkel Cell Polyomavirus-Infected Merkel Cell Carcinoma Cells Require Expression of Viral T Antigens

2010 ◽  
Vol 84 (14) ◽  
pp. 7064-7072 ◽  
Author(s):  
Roland Houben ◽  
Masahiro Shuda ◽  
Rita Weinkam ◽  
David Schrama ◽  
Huichen Feng ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Cell Lines ◽  
Merkel Cell Carcinoma ◽  
Annexin V ◽  
T Antigen ◽  
Merkel Cell Polyomavirus ◽  
Merkel Cell ◽  
T Antigens ◽  
Negative Cell ◽  
Exon 1

ABSTRACT Merkel cell carcinoma (MCC) is the most aggressive skin cancer. Recently, it was demonstrated that human Merkel cell polyomavirus (MCV) is clonally integrated in ∼80% of MCC tumors. However, direct evidence for whether oncogenic viral proteins are needed for the maintenance of MCC cells is still missing. To address this question, we knocked down MCV T-antigen (TA) expression in MCV-positive MCC cell lines using three different short hairpin RNA (shRNA)-expressing vectors targeting exon 1 of the TAs. The MCC cell lines used include three newly generated MCV-infected cell lines and one MCV-negative cell line from MCC tumors. Notably, all MCV-positive MCC cell lines underwent growth arrest and/or cell death upon TA knockdown, whereas the proliferation of MCV-negative cell lines remained unaffected. Despite an increase in the number of annexin V-positive, 7-amino-actinomycin D (7-AAD)-negative cells upon TA knockdown, activation of caspases or changes in the expression and phosphorylation of Bcl-2 family members were not consistently detected after TA suppression. Our study provides the first direct experimental evidence that TA expression is necessary for the maintenance of MCV-positive MCC and that MCV is the infectious cause of MCV-positive MCC.

scholarly journals Characterization of a Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Cell Line CVG-1

2018 ◽  
Vol 9 ◽  
Author(s):  
Celestino Velásquez ◽  
Yutaka Amako ◽  
Alexis Harold ◽  
Tuna Toptan ◽  
Yuan Chang ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Cell Line ◽  
Merkel Cell Carcinoma ◽  
Carcinoma Cell ◽  
Merkel Cell Polyomavirus ◽  
Carcinoma Cell Line ◽  
Merkel Cell
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