scholarly journals Survivin downregulation is not required for T antigen knockdown mediated cell growth inhibition in MCV infected merkel cell carcinoma cells

2012 ◽  
Vol 132 (12) ◽  
pp. 2980-2982 ◽  
Author(s):  
David Schrama ◽  
Sonja Hesbacher ◽  
Jürgen C. Becker ◽  
Roland Houben
Keyword(s):  
Cell Growth ◽  
Growth Inhibition ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
T Antigen ◽  
Carcinoma Cells ◽  
Merkel Cell ◽  
Cell Growth Inhibition

scholarly journals Merkel Cell Polyomavirus–Positive Merkel Cell Carcinoma Cells Do Not Require Expression of the Viral Small T Antigen

2013 ◽  
Vol 133 (8) ◽  
pp. 2059-2064 ◽  
Author(s):  
Sabrina Angermeyer ◽  
Sonja Hesbacher ◽  
Jürgen C. Becker ◽  
David Schrama ◽  
Roland Houben
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
T Antigen ◽  
Merkel Cell Polyomavirus ◽  
Carcinoma Cells ◽  
Merkel Cell ◽  
Small T Antigen

scholarly journals Serine 220 phosphorylation of the Merkel cell polyomavirus large T antigen crucially supports growth of Merkel cell carcinoma cells

2015 ◽  
Vol 138 (5) ◽  
pp. 1153-1162 ◽  
Author(s):  
David Schrama ◽  
Sonja Hesbacher ◽  
Sabrina Angermeyer ◽  
Andreas Schlosser ◽  
Sebastian Haferkamp ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
T Antigen ◽  
Merkel Cell Polyomavirus ◽  
Carcinoma Cells ◽  
Merkel Cell ◽  
Large T Antigen

Inhibition of T-antigen expression promoting glycogen synthase kinase 3 impairs merkel cell carcinoma cell growth

2022 ◽  
Vol 524 ◽  
pp. 259-267
Author(s):  
Roland Houben ◽  
Sonja Hesbacher ◽  
Bhavishya Sarma ◽  
Carolin Schulte ◽  
Eva-Maria Sarosi ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Carcinoma Cell ◽  
Glycogen Synthase ◽  
Antigen Expression ◽  
T Antigen ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Merkel Cell

scholarly journals RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells

Oncotarget ◽  
2016 ◽  
Vol 7 (22) ◽  
pp. 32956-32968 ◽  
Author(s):  
Sonja Hesbacher ◽  
Lisa Pfitzer ◽  
Katharina Wiedorfer ◽  
Sabrina Angermeyer ◽  
Andreas Borst ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
T Antigen ◽  
Merkel Cell Polyomavirus ◽  
Carcinoma Cells ◽  
Merkel Cell ◽  
Large T Antigen

scholarly journals Suppression of SOCS3 enhances TRAIL-induced cell growth inhibition through the upregulation of DR4 expression in renal cell carcinoma cells

Oncotarget ◽  
2018 ◽  
Vol 9 (60) ◽  
pp. 31697-31708 ◽  
Author(s):  
Michihiro Yabe ◽  
Kei Ishibashi ◽  
Akifumi Onagi ◽  
Ryo Tanji ◽  
Ruriko Honda-Takinami ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Growth ◽  
Growth Inhibition ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Carcinoma Cells ◽  
Cell Growth Inhibition

scholarly journals Merkel Cell Polyomavirus Large T Antigen is Dispensable in G2 and M-Phase to Promote Proliferation of Merkel Cell Carcinoma Cells

Viruses ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 1162
Author(s):  
Roland Houben ◽  
Marlies Ebert ◽  
Sonja Hesbacher ◽  
Thibault Kervarrec ◽  
David Schrama
Keyword(s):  
Cell Cycle ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
T Antigen ◽  
Merkel Cell Polyomavirus ◽  
Carcinoma Cells ◽  
Merkel Cell ◽  
Large T Antigen ◽  
M Phase ◽  
G2 Phase

Merkel cell carcinoma (MCC) is an aggressive skin cancer frequently caused by the Merkel cell polyomavirus (MCPyV), and proliferation of MCPyV-positive MCC tumor cells depends on the expression of a virus-encoded truncated Large T antigen (LT) oncoprotein. Here, we asked in which phases of the cell cycle LT activity is required for MCC cell proliferation. Hence, we generated fusion-proteins of MCPyV-LT and parts of geminin (GMMN) or chromatin licensing and DNA replication factor1 (CDT1). This allowed us to ectopically express an LT, which is degraded either in the G1 or G2 phase of the cell cycle, respectively, in MCC cells with inducible T antigen knockdown. We demonstrate that LT expressed only in G1 is capable of rescuing LT knockdown-induced growth suppression while LT expressed in S and G2/M phases fails to support proliferation of MCC cells. These results suggest that the crucial function of LT, which has been demonstrated to be inactivation of the cellular Retinoblastoma protein 1 (RB1) is only required to initiate S phase entry.

scholarly journals Tropomyosin Receptor Kinase A Expression on Merkel Cell Carcinoma Cells

2017 ◽  
Vol 153 (11) ◽  
pp. 1166 ◽  
Author(s):  
Ulrike Wehkamp ◽  
Sophie Stern ◽  
Sandra Krüger ◽  
Axel Hauschild ◽  
Christoph Röcken ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Carcinoma Cells ◽  
Merkel Cell ◽  
Receptor Kinase ◽  
Kinase A
Sign in / Sign up

Export Citation Format

Share Document