scholarly journals Universal screening for Lynch syndrome in a large consecutive cohort of Chinese colorectal cancer patients: High prevalence and unique molecular features

2019 ◽  
Vol 144 (9) ◽  
pp. 2161-2168 ◽  
Author(s):  
Wu Jiang ◽  
Mu-Yan Cai ◽  
Shi-Yong Li ◽  
Jin-Xin Bei ◽  
Fang Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lynch Syndrome ◽  
Cancer Patients ◽  
Universal Screening ◽  
Molecular Features ◽  
High Prevalence ◽  
Colorectal Cancer Patients

scholarly journals Biomarker testing and mutation prevalence in metastatic colorectal cancer patients in five European countries using a large oncology database

2021 ◽  
Author(s):  
George Kafatos ◽  
Victoria Banks ◽  
Peter Burdon ◽  
David Neasham ◽  
Caroline Anger ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Practice ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Braf Mutation ◽  
European Countries ◽  
High Prevalence ◽  
Biomarker Testing ◽  
Colorectal Cancer Patients ◽  
Over Time

Background: The literature on biomarker testing for metastatic colorectal cancer (mCRC) in Europe is scarce. This study aimed to estimate the percentage of mCRC patients from five European countries tested for biomarkers over time. Materials & methods: An oncology database was retrospectively analyzed; evaluated biomarkers were RAS, BRAF and microsatellite instability (MSI). The patients were drug treated during 2018 and tested for relevant biomarkers in 2013–2018. Results: RAS testing was conducted in >90% of mCRC patients from 2014 onwards. BRAF testing increased from 31% of mCRC patients in 2013 to 67% in 2018. MSI testing increased from 10 to 41%. There was no notable trend over time for RAS and BRAF mutation or MSI-high prevalence. Conclusion: Biomarker testing among patients diagnosed with mCRC was increased over time. This study demonstrates the quick uptake of biomarker testing in clinical practice. These findings are significant as biomarker-based drugs are becoming more common.

scholarly journals A model-based assessment of the cost–utility of strategies to identify Lynch syndrome in early-onset colorectal cancer patients

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Tristan Snowsill ◽  
Nicola Huxley ◽  
Martin Hoyle ◽  
Tracey Jones-Hughes ◽  
Helen Coelho ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lynch Syndrome ◽  
Cancer Patients ◽  
Early Onset ◽  
Cost Utility ◽  
Model Based ◽  
Colorectal Cancer Patients ◽  
The Cost ◽  
Early Onset Colorectal Cancer

The different immune profiles of normal colonic mucosa in cancer-free Lynch syndrome carriers and Lynch syndrome colorectal cancer patients

2021 ◽  
Author(s):  
Lena Bohaumilitzky ◽  
Klaus Kluck ◽  
Robert Hüneburg ◽  
Richard Gallon ◽  
Jacob Nattermann ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lynch Syndrome ◽  
Cancer Patients ◽  
Colonic Mucosa ◽  
Normal Colonic Mucosa ◽  
Colorectal Cancer Patients

Lynch syndrome in colorectal cancer patients

2008 ◽  
Vol 8 (4) ◽  
pp. 573-583 ◽  
Author(s):  
M Dolores Giráldez ◽  
Sergi Castellví-Bel ◽  
Francesc Balaguer ◽  
Victòria Gonzalo ◽  
Teresa Ocaña ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lynch Syndrome ◽  
Cancer Patients ◽  
Colorectal Cancer Patients

scholarly journals Cost-effectiveness of routine screening for Lynch syndrome in colorectal cancer patients up to 70 years of age

2016 ◽  
Vol 18 (10) ◽  
pp. 966-973 ◽  
Author(s):  
Celine H. M. Leenen ◽  
◽  
Anne Goverde ◽  
Esther W. de Bekker-Grob ◽  
Anja Wagner ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cost Effectiveness ◽  
Lynch Syndrome ◽  
Cancer Patients ◽  
Routine Screening ◽  
Colorectal Cancer Patients
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