scholarly journals Circulating tumor DNA for prognosis assessment and postoperative management after curative‐intent resection of colorectal liver metastases

2022 ◽  
Author(s):  
Thomas Reinert ◽  
Lena Marie Skindhøj Petersen ◽  
Tenna Vesterman Henriksen ◽  
Marie Øbo Larsen ◽  
Mads Heilskov Rasmussen ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Circulating Tumor Dna ◽  
Postoperative Management ◽  
Curative Intent ◽  
Tumor Dna

scholarly journals Circulating Tumor DNA as Surveillance Following Resection of Colorectal Liver Metastases - Results from a Prospective Single Center Trial

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S18-S19
Author(s):  
A.R. Knudsen ◽  
M.Ø. Larsen ◽  
M. Meier ◽  
L.M.S. Petersen ◽  
F.V. Mortensen ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Circulating Tumor Dna ◽  
Single Center ◽  
Tumor Dna

scholarly journals Dynamic monitoring of circulating tumor DNA to predict prognosis and efficacy of adjuvant chemotherapy after resection of colorectal liver metastases

Theranostics ◽  
2021 ◽  
Vol 11 (14) ◽  
pp. 7018-7028
Author(s):  
De-Shen Wang ◽  
Hui Yang ◽  
Xiao-Yun Liu ◽  
Zhi-Gang Chen ◽  
Yun Wang ◽  
...  
Keyword(s):  
Adjuvant Chemotherapy ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Circulating Tumor Dna ◽  
Dynamic Monitoring ◽  
Tumor Dna

Impact of Preoperative Circulating Tumor DNA Status on Survival Outcomes After Hepatectomy for Resectable Colorectal Liver Metastases

2021 ◽  
Author(s):  
Shin Kobayashi ◽  
Yoshiaki Nakamura ◽  
Hiroya Taniguchi ◽  
Justin I. Odegaard ◽  
Shogo Nomura ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Circulating Tumor Dna ◽  
Survival Outcomes ◽  
Tumor Dna

scholarly journals Detection of Tumor Recurrence via Circulating Tumor DNA Profiling in Patients with Localized Lung Cancer: Clinical Considerations and Challenges

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3759
Author(s):  
Bryan Ulrich ◽  
Anne Pradines ◽  
Julien Mazières ◽  
Nicolas Guibert
Keyword(s):  
Lung Cancer ◽  
Residual Disease ◽  
Lung Cancer Screening ◽  
Circulating Tumor Dna ◽  
Definitive Treatment ◽  
Curative Intent ◽  
Screening Programs ◽  
Adjuvant Therapies ◽  
Sequencing Platforms ◽  
Tumor Dna

Approximately 30% of patients with non-small-cell lung cancer (NSCLC) present with localized/non-metastatic disease and are eligible for surgical resection or other “treatment with curative intent”. Due to the high prevalence of recurrence after treatment, adjuvant therapy is standard care for most patients. The effect of adjuvant chemotherapy is, however, modest, and new tools are needed to identify candidates for adjuvant treatments (chemotherapy, immunotherapy, or targeted therapies), especially since expanded lung cancer screening programs will increase the rate of patients detected with localized NSCLC. Circulating tumor DNA (ctDNA) has shown strong potential to detect minimal residual disease (MRD) and to guide adjuvant therapies. In this manuscript, we review the technical aspects and performances of the main ctDNA sequencing platforms (TRACERx, CAPP-seq) investigated in this purpose, and discuss the potential of this approach to guide or spare adjuvant therapies after definitive treatment of NSCLC.

scholarly journals FIRST BRAZILIAN CONSENSUS ON MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES. MODULE 1: PRE-TREATMENT EVALUATION

2015 ◽  
Vol 28 (4) ◽  
pp. 222-230 ◽  
Author(s):  
Felipe José Fernandez COIMBRA ◽  
Heber Salvador de Castro RIBEIRO ◽  
Márcio Carmona MARQUES ◽  
Paulo HERMAN ◽  
Rubens CHOJNIAK ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases ◽  
Epidemiological Data ◽  
Treatment Modalities ◽  
Established Method ◽  
Curative Intent ◽  
Pre Treatment ◽  
Definition Of

Background : Liver metastases of colorectal cancer are frequent and potentially fatal event in the evolution of patients with these tumors. Aim : In this module, was contextualized the clinical situations and parameterized epidemiological data and results of the various treatment modalities established. Method: Was realized deep discussion on detecting and staging metastatic colorectal cancer, as well as employment of imaging methods in the evaluation of response to instituted systemic therapy. Results : The next step was based on the definition of which patients would have their metastases considered resectable and how to expand the amount of patients elegible for modalities with curative intent. Conclusion : Were presented clinical, pathological and molecular prognostic factors, validated to be taken into account in clinical practice.

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