Bone formation in calvarial defects of Sprague-Dawley rats by transplantation of calcium phosphate glass

2005 ◽  
Vol 74A (3) ◽  
pp. 497-502 ◽  
Author(s):  
Hyun-Ju Moon ◽  
Kyoung-Nam Kim ◽  
Kwang-Mahn Kim ◽  
Seong-Ho Choi ◽  
Chong-Kwan Kim ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Phosphate Glass ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Calvarial Defects

Effect of calcium phosphate glass on bone formation in calvarial defects of Sprague-Dawley rats

2006 ◽  
Vol 17 (9) ◽  
pp. 807-813 ◽  
Author(s):  
Hyun-Ju Moon ◽  
Kyoung-Nam Kim ◽  
Kwang-Mahn Kim ◽  
Seong-Ho Choi ◽  
Chong-Kwan Kim ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Phosphate Glass ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Calvarial Defects

Effect of Particle Size on New Bone Formation In Vivo Using Calcium Phopshate Glass

2007 ◽  
Vol 330-332 ◽  
pp. 165-168
Author(s):  
Hyun Ju Moon ◽  
Racquel Z. LeGeros ◽  
Kyoung Nam Kim ◽  
Kwang Mahn Kim ◽  
Seong Ho Choi ◽  
...  
Keyword(s):  
Particle Size ◽  
Calcium Phosphate ◽  
Bone Formation ◽  
Phosphate Glass ◽  
Glass Powder ◽  
New Bone Formation ◽  
Sprague Dawley ◽  
Constant Weight ◽  
Calvarial Defects

The purpose of this study was to compare the bone regenerative effect of calcium phosphate glass according to the particle size in vivo. We prepared two different sizes, that is 400 μm and 40 μm, of calcium phosphate glass powder using the system CaO-CaF2-P2O5-MgO-ZnO. Critical-sized calvarial defects were created in 60 male Sprague-Dawley rats. The animals were divided into 3 groups of 20 animals each. Each defect was filled with a constant weight of 0.5 g calcium phosphate glass powder mixed with saline. As controls, the defect was left empty. The rats were sacrificed 2 or 8 weeks after postsurgery, and the results were evaluated using histological as well as histomorphometrical studies. The particle size of the calcium phosphate was crucial; 400 μm particles promoted new bone formation, while 40 μm particles inhibited it because of severe inflammation.

Regulation of bone repletion in rats subjected to varying low-calcium stress

1984 ◽  
Vol 246 (2) ◽  
pp. R190-R196 ◽  
Author(s):  
R. H. Drivdahl ◽  
C. C. Liu ◽  
D. J. Baylink
Keyword(s):  
Bone Formation ◽  
Formation Rate ◽  
Bone Volume ◽  
Strong Positive Correlation ◽  
Sprague Dawley ◽  
Bone Formation Rate ◽  
Osteoblast Activity ◽  
Calcium Stress ◽  
Sprague Dawley Rats ◽  
Very High

Weanling Sprague-Dawley rats subjected to varying degrees of low-Ca dietary stress (depletion) showed graded increases in the rate of endosteal bone formation when normal dietary Ca was restored (repletion). There was a strong positive correlation between the rate of bone resorption in depletion and the rate of bone formation attained after 1 wk of repletion. However, bone formation declined rapidly within the first 4 wk of repletion, despite the persistence of a substantial endosteal bone volume deficit. Furthermore the medullary area (indicative of bone volume) did not by itself determine the bone formation rate. Bone volume in test groups was restored to control levels after 6 mo of repletion, and this result could be predicted by a kinetic analysis. Thus, although very high rates of formation in early repletion decline rapidly, smaller increments relative to controls must be sustained for long periods. Our data indicate that increased formation rats at all stages of repletion are a consequence of elevations in both osteoblast number and osteoblast activity.

Osteoconductive effects of calcium phosphate glass cement grafts in rabbit calvarial defects

2010 ◽  
Vol 95B (1) ◽  
pp. 47-52 ◽  
Author(s):  
Hyun-Chang Lim ◽  
Joo-Yeon Sohn ◽  
Jung-Chul Park ◽  
Yoo-Jung Um ◽  
Ui-Won Jung ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Phosphate Glass ◽  
Calvarial Defects

Investigation of Bone Formation using Non-Crystalline Calcium Phosphate Glass in Beagle Dogs

2003 ◽  
Vol 240-242 ◽  
pp. 391-394 ◽  
Author(s):  
Yong Keun Lee ◽  
H.S. Kim ◽  
Kyoo Sung Cho ◽  
Kyoung Nam Kim ◽  
Seong Ho Choi
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Phosphate Glass ◽  
Beagle Dogs

Bone Formation of Intrabony Defects in Beagle Dogs Using Calcium Phosphate Glass and Glass-Ceramics

2005 ◽  
pp. 957-960
Author(s):  
Seong Ho Choi ◽  
D.H. Baik ◽  
C.S. Kim ◽  
Chong Kwan Kim ◽  
Kyoung Nam Kim ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Phosphate Glass ◽  
Glass Ceramics ◽  
Beagle Dogs ◽  
Intrabony Defects

Quercetin prevents experimental glucocorticoid-induced osteoporosis: a comparative study with alendronate

2013 ◽  
Vol 91 (5) ◽  
pp. 380-385 ◽  
Author(s):  
Hoda Derakhshanian ◽  
Mahmoud Djalali ◽  
Abolghassem Djazayery ◽  
Keramat Nourijelyani ◽  
Sajad Ghadbeigi ◽  
...  
Keyword(s):  
Bone Formation ◽  
Breaking Strength ◽  
Sodium Succinate ◽  
Treated Group ◽  
Common Type ◽  
Bone Formation Marker ◽  
Sprague Dawley ◽  
Oral Gavage ◽  
Methylprednisolone Sodium Succinate ◽  
Sprague Dawley Rats

Glucocorticoid-induced osteoporosis (GIO) is the most common type of secondary osteoporosis. The aim of this study was to compare the efficacy of quercetin, a plant-derived flavonoid, with alendronate in the prevention of GIO. Fifty-six Sprague–Dawley rats were randomly distributed among 7 groups (8 rats per group) and treated for 6 weeks with one of the following: (i) normal saline; (ii) 40 mg methylprednisolone sodium succinate (MP)/kg body mass; (iii) MP + 40 μg alendronate/kg; (iv) MP + 50 mg quercetin/kg; (v) MP + 40 μg alendronate/kg + 50 mg quercetin/kg; (vi) MP + 150 mg quercetin/kg; and (vii) MP + 40 μg alendronate/kg + 150 mg quercetin/kg. MP and alendronate were injected subcutaneously and quercetin was administered by oral gavage 3 days a week. At the end of the study, femur breaking strength was significantly decreased as a consequence of MP injection. This decrease was completely compensated for in groups receiving 50 mg quercetin/kg plus alendronate, and 150 mg quercetin/kg with or without alendronate. Quercetin noticeably elevated osteocalcin as a bone formation marker, while alendronate did not show such an effect. In addition, administration of 150 mg quercetin/kg increased femoral trabecular and cortical thickness by 36% and 22%, respectively, compared with the MP-treated group. These data suggest that 150 mg quercetin/kg, alone or in combination with alendronate, can completely prevent GIO through its bone formation stimulatory effect.

scholarly journals Bone remodeling effect of a chitosan and calcium phosphate-based composite

2019 ◽  
Vol 6 (4) ◽  
pp. 241-247 ◽  
Author(s):  
Lilja Kjalarsdóttir ◽  
Arna Dýrfjörd ◽  
Atli Dagbjartsson ◽  
Elín H Laxdal ◽  
Gissur Örlygsson ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Bone Remodeling ◽  
Morphological Changes ◽  
Drill Hole ◽  
New Bone Formation ◽  
Sprague Dawley ◽  
Time Points ◽  
Formation Pattern ◽  
Rat Mandible

Abstract Chitosan is a biocompatible polymer that has been widely studied for tissue engineering purposes. The aim of this research was to assess bone regenerative properties of an injectable chitosan and calcium phosphate-based composite and identify optimal degree of deacetylation (%DDA) of the chitosan polymer. Drill holes were generated on the left side of a mandible in Sprague-Dawley rats, and the hole was either left empty or filled with the implant. The animals were sacrificed at several time points after surgery (7–22 days) and bone was investigated using micro-CT and histology. No significant new bone formation was observed in the implants themselves at any time points. However, substantial new bone formation was observed in the rat mandible further away from the drill hole. Morphological changes indicating bone formation were found in specimens explanted on Day 7 in animals that received implant. Similar bone formation pattern was seen in control animals with an empty drill hole at later time points but not to the same extent. A second experiment was performed to examine if the %DDA of the chitosan polymer influenced the bone remodeling response. The results suggest that chitosan polymers with %DDA between 50 and 70% enhance the natural bone remodeling mechanism.

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