scholarly journals Chondrogenic differentiation of human mesenchymal stem cell aggregates via controlled release of TGF-β1 from incorporated polymer microspheres

2009 ◽  
Vol 9999A ◽  
pp. NA-NA ◽  
Author(s):  
Loran D. Solorio ◽  
Andrew S. Fu ◽  
Roberto Hernández-Irizarry ◽  
Eben Alsberg
Keyword(s):  
Stem Cell ◽  
Controlled Release ◽  
Mesenchymal Stem Cell ◽  
Chondrogenic Differentiation ◽  
Human Mesenchymal Stem Cell ◽  
Polymer Microspheres ◽  
Cell Aggregates ◽  
Tgf Β1

scholarly journals Correlation Between Compositional and Mechanical Properties of Human Mesenchymal Stem Cell-Collagen Microspheres During Chondrogenic Differentiation

2011 ◽  
Vol 17 (5-6) ◽  
pp. 777-788 ◽  
Author(s):  
Chun-hei Li ◽  
Tsz-Kit Chik ◽  
Alfonso H.W. Ngan ◽  
Stanley C.H. Chan ◽  
Daisy K.Y. Shum ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Chondrogenic Differentiation ◽  
Human Mesenchymal Stem Cell

scholarly journals PKCη Regulates the TGFβ3-induced Chondrogenic Differentiation of Human Mesenchymal Stem Cell

2013 ◽  
Vol 17 (4) ◽  
pp. 299-309 ◽  
Author(s):  
Bo Mi Ku ◽  
Young Phil Yune ◽  
Eun Shin Lee ◽  
Young-Sool Hah ◽  
Jae Yong Park ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Chondrogenic Differentiation ◽  
Human Mesenchymal Stem Cell

TiO 2 coating promotes human mesenchymal stem cell proliferation without the loss of their capacity for chondrogenic differentiation

2013 ◽  
Vol 5 (2) ◽  
pp. 025009 ◽  
Author(s):  
Salla Kaitainen ◽  
Anssi J Mähönen ◽  
Reijo Lappalainen ◽  
Heikki Kröger ◽  
Mikko J Lammi ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Chondrogenic Differentiation ◽  
Human Mesenchymal Stem Cell ◽  
Stem Cell Proliferation

scholarly journals lncRNA ADAMTS9-AS2 Controls Human Mesenchymal Stem Cell Chondrogenic Differentiation and Functions as a ceRNA

2019 ◽  
Vol 18 ◽  
pp. 533-545 ◽  
Author(s):  
Ming-Jian Huang ◽  
Jing-Yu Zhao ◽  
Jia-Jia Xu ◽  
Jing Li ◽  
Yi-Fu Zhuang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Chondrogenic Differentiation ◽  
Human Mesenchymal Stem Cell

scholarly journals Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Samuel Herberg ◽  
Daniel Varghai ◽  
Daniel S. Alt ◽  
Phuong N. Dang ◽  
Honghyun Park ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Human Mesenchymal Stem Cell ◽  
Functional Restoration ◽  
Defect Healing ◽  
Tgf Β1

AbstractBiomimetic bone tissue engineering strategies partially recapitulate development. We recently showed functional restoration of femoral defects using scaffold-free human mesenchymal stem cell (hMSC) condensates featuring localized morphogen presentation with delayed in vivo mechanical loading. Possible effects of construct geometry on healing outcome remain unclear. Here, we hypothesized that localized presentation of transforming growth factor (TGF)-β1 and bone morphogenetic protein (BMP)-2 to engineered hMSC tubes mimicking femoral diaphyses induces endochondral ossification, and that TGF-β1 + BMP-2-presenting hMSC tubes enhance defect healing with delayed in vivo loading vs. loosely packed hMSC sheets. Localized morphogen presentation stimulated chondrogenic priming/endochondral differentiation in vitro. Subcutaneously, hMSC tubes formed cartilage templates that underwent bony remodeling. Orthotopically, hMSC tubes stimulated more robust endochondral defect healing vs. hMSC sheets. Tissue resembling normal growth plate was observed with negligible ectopic bone. This study demonstrates interactions between hMSC condensation geometry, morphogen bioavailability, and mechanical cues to recapitulate development for biomimetic bone tissue engineering.

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