Poly‐( L ‐lactic acid) and citric acid‐crosslinked gelatin composite matrices as a drug‐eluting stent coating material with endothelialization, antithrombogenic, and drug release properties

2012 ◽  
Vol 101A (7) ◽  
pp. 2049-2057 ◽  
Author(s):  
Motoki Inoue ◽  
Makoto Sasaki ◽  
Yasuyuki Katada ◽  
Katsuhito Fujiu ◽  
Ichiro Manabe ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Citric Acid ◽  
Drug Release ◽  
Coating Material ◽  
Drug Eluting Stent ◽  
Drug Eluting ◽  
Stent Coating

scholarly journals Tamibarotene-loaded citric acid-crosslinked alkali-treated collagen matrix as a coating material for a drug-eluting stent

2012 ◽  
Vol 13 (6) ◽  
pp. 064208 ◽  
Author(s):  
Motoki Inoue ◽  
Mariko Takayanagi ◽  
Katsuhito Fujiu ◽  
Ichiro Manabe ◽  
Ryozo Nagai ◽  
...  
Keyword(s):  
Citric Acid ◽  
Collagen Matrix ◽  
Coating Material ◽  
Drug Eluting Stent ◽  
Drug Eluting

scholarly journals Influence of Elongation of Paclitaxel-Eluting Electrospun-Produced Stent Coating on Paclitaxel Release and Transport Through the Arterial Wall after Stenting

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1165
Author(s):  
Zhanna K. Nazarkina ◽  
Boris P. Chelobanov ◽  
Konstantin A. Kuznetsov ◽  
Alexey V. Shutov ◽  
Irina V. Romanova ◽  
...  
Keyword(s):  
Drug Release ◽  
Arterial Wall ◽  
Release Kinetics ◽  
Artery Wall ◽  
Vascular Stents ◽  
Drug Eluting ◽  
Fiber Breaks ◽  
Stent Diameter ◽  
Stent Coating

It was previously shown that polycaprolactone (PCL)-based electrospun-produced paclitaxel (PTX)-enriched matrices exhibit long-term drug release kinetics and can be used as coatings for drug-eluting stents (DES). The installation of vascular stents involves a twofold increase in stent diameter and, therefore, an elongation of the matrices covering the stents, as well as the arterial wall in a stented area. We studied the influence of matrix elongation on its structure and PTX release using three different electrospun-produced matrices. The data obtained demonstrate that matrix elongation during stent installation does not lead to fiber breaks and does not interfere with the kinetics of PTX release. To study PTX diffusion through the expanded artery wall, stents coated with 5%PCL/10%HSA/3%DMSO/PTX and containing tritium-labeled PTX were installed into the freshly obtained iliac artery of a rabbit. The PTX passing through the artery wall was quantified using a scintillator β-counter. The artery retained the PTX and decreased its release from the coating. The retention of PTX by the arterial wall was more efficient when incubated in blood plasma in comparison with PBS. The retention/accumulation of PTX by the arterial wall provides a prolonged drug release and allows for the reduction in the dose of the drugs in electrospun-produced stent coatings.

Development of a novel biocompatible polymer system for extended drug release in a next-generation drug-eluting stent

2008 ◽  
Vol 85A (4) ◽  
pp. 1064-1071 ◽  
Author(s):  
Kishore Udipi ◽  
Mingfei Chen ◽  
Peiwen Cheng ◽  
Kevin Jiang ◽  
Diane Judd ◽  
...  
Keyword(s):  
Drug Release ◽  
Polymer System ◽  
Drug Eluting Stent ◽  
Next Generation ◽  
Biocompatible Polymer ◽  
Drug Eluting
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