Controlled and localized antibiotics delivery using magnetic‐responsive beads for synergistic treatment of orthopedic infection

2022 ◽  
Author(s):  
Ali Shademani ◽  
John K. Jackson ◽  
Charles J. Thompson ◽  
Mu Chiao
Keyword(s):  
Orthopedic Infection

Evaluation of Structure-Controlled Silk Fibroin Coatings for Orthopedic Infection and In-Situ Osteogenesis: In Vitro and In Vivo

2020 ◽  
Author(s):  
Wenhao Zhou ◽  
Teng Zhang ◽  
Jianglong Yan ◽  
QiYao Li ◽  
Panpan Xiong ◽  
...  
Keyword(s):  
Silk Fibroin ◽  
Orthopedic Infection

Pseudomonas in Orthopedic Infection

1974 ◽  
Vol 9 (1) ◽  
pp. 125
Author(s):  
Myung Sang Moon ◽  
Sang Tai Kim ◽  
Young Keun Park
Keyword(s):  
Orthopedic Infection

Principles of Orthopedic Infection Management

2018 ◽  
Vol 50 (01) ◽  
pp. 62-62
Keyword(s):  
Infection Management ◽  
Orthopedic Infection

Das Werk aus der bewährten AO Trauma Reihe befasst sich mit einem oftmals wenig populären, aber trotz allem äußerst wichtigen Thema, das vor allem durch die Medien zunehmend in den Fokus der Gesellschaft gerückt wird. Dieses Thema nimmt für gewöhnlich nicht die zentrale Stelle in der Facharztweiterbildung ein, die es in Anbetracht der Konsequenzen haben sollte. Umso erfreulicher und relevanter wird das Vorhalten von geeigneter Literatur, um diese Lücke zu schließen. Die Herausgeber haben eine internationale und namhafte Autorenschaft für dieses Thema gewinnen können.

scholarly journals Adverse Trends in the Etiology of Orthopedic Infection: Results of 6-Year Monitoring of the Structure and Resistance of Leading Pathogens

2018 ◽  
Vol 24 (4) ◽  
pp. 20-31 ◽  
Author(s):  
S. A. Bozhkova ◽  
A. R. Kasimova ◽  
R. M. Tikhilov ◽  
E. M. Polyakova ◽  
A. N. Rukina ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Antibiotic Therapy ◽  
Periprosthetic Infection ◽  
Statistical Processing ◽  
Microbial Pathogens ◽  
Species Structure ◽  
Oral Antibiotic ◽  
Treatment Regimens ◽  
Acinetobacter Sp ◽  
Orthopedic Infection

Osteomyelitis remains one of the most intractable diseases. The nature of the pathogen and its resistance to antibiotics significantly affect the outcome and cost of treatment.The aim of the study: to analyze the dynamics of the spectrum and antibiotic resistance of the leading pathogens of orthopedic infection for the period 2012– 2017.Material and methods. The structure of pathogens isolated from the focus of infection from 2774 patients with periprosthetic infection and chronic osteomyelitis was retrospectively analyzed. Antibiotic resistance of the leading pathogens that occupied more than 4% in the species structure was studied. Comparative analysis of changes in the spectrum of pathogens and antibiotic resistance was carried out for the periods 2012-2013, 2014–2015 and 2016-2017. Epidemiological analysis was performed in the program „microbiological monitoring system” Microbe-2. Statistical processing of the obtained data was carried out using the Z-criterion.Results.From 2774 patients with orthopedic infection have been isolated 4359 strains, in the structure of which about 73.5% were occupied by S. aureus, S. epidermidis, E. faecalis, E. faecium, P. aeruginosa, Acinetobacter sp. representatives of the family Enterobacteriacea. In 27% of the cases, microorganisms of other species were identified. Microbial associations were identified in 19.4% of cases. In the structure of the leading Gram(+) pathogens, a significant decrease in the incidence of S. aureus was detected, while the share of S. epidermidis increased significantly. Among the leading Gram(-) microorganisms, a significant increase in the proportion of representatives of the fam. Enterobacteriacea was found, against the background of a decrease in the share of Acinetobacter sp. and P. aeruginosa. The level of resistance of MSSA to the studied antibiotics ranged from 0.1 to 8.8%, for MSSE the spread was from 1.9 to 16.7%. Negative dynamics of growth of resistance of non-fermenting bacteria is established. The strains of Acinetobacter sp. demonstrated greater resistance to tested antibiotics in comparison with P. aeruginosa.Conclusion.An increase in the role of S. epidermidis and K. pneumoniae in the etiology of orthopedic infection was established. The revealed increase in the resistance of microbial pathogens to most tested and used antibiotics should be taken into account in the appointment of empirical antibiotic therapy. The extremely high frequency of resistance of gram-negative bacteria to cephalosporins and fluoroquinolones excludes the possibility of their empirical use, which requires the management of carbapenems in the starting treatment regimens. High resistance to fluoroquinolones limits the ability of oral antibiotic therapy in patients with periprosthetic infection. 

scholarly journals Resistance of carbapenemase-producing Klebsiella pneumoniae isolated from patients with orthopedic infection

2020 ◽  
Vol 22 (1) ◽  
pp. 47-52
Author(s):  
S.A. Bozhkova ◽  
E.M. Gordina ◽  
O.V. Schneider ◽  
A.N. Rukina ◽  
V.V. Shabanova
Keyword(s):  
Klebsiella Pneumoniae ◽  
Antimicrobial Agents ◽  
Molecular Genetic ◽  
Molecular Genetic Analysis ◽  
Resistance Rate ◽  
Tissue Samples ◽  
Phenotypic Resistance ◽  
Russian Research Institute ◽  
Orthopedic Infection ◽  
Russian Research

Objective. To evaluate the resistance rate and production of carbapenemases in Klebsiella pneumoniae with phenotypic resistance to carbapenems isolated from patients with orthopedic infection. Materials and Methods. The materials for the study were tissue samples, aspirates and removed orthopedic devices of patients with orthopedic infection at the Vreden Russian Research Institute of Traumatology and Orthopedics, between 2017 and 2019. K. pneumoniae strains were identified in Microlatest by iEMS ReaderMF. These strains were tested for susceptibility to 15 antimicrobial agents by disk diffusion methods, as described by the EUCAST. The carbapenemase genes were investigated by RT-PCR. Results. Of 858 isolated cultures, 6.8% were resistant to carbapenems. Molecular genetic analysis showed that 43.1% of the cultures had blaNDM gene and 24.1% blaOXA-48. All isolates of K. pneumoniae were characterized by resistance to cefotaxime, moxifloxacin and ciprofloxacin. OXA-48-strains were MDR in 50.0% of cases, XDR in 42.9%, PDR in 7.1%. Strains with NDM-carbapenemases were XDR in 68.0% and PDR in 32.0% of cases. The most effective antibiotic was fosfomycin. Thus, 66.7% of NDM-isolates demonstrated sensitivity to fosfomycin. One isolate was PDR with both NDM and OXA-48. Conclusions. Over the period of three years, carbapenemase-producing K. pneumoniae were isolated in the orthopedic hospital. These isolates were not only resistant to carbapenems, but also to a number of other antimicrobial agents. Isolates differed in resistance phenotypes depending on the presence of carbapenemases group, while strains with gene blaNDM were more resistant than those with blaOXA-48.

scholarly journals Preliminary evaluation of technetium-99m-labeled ceftriaxone: infection imaging agent for the clinical diagnosis of orthopedic infection

2013 ◽  
Vol 17 (4) ◽  
pp. e263-e270 ◽  
Author(s):  
Ankur Kaul ◽  
Puja P. Hazari ◽  
Harish Rawat ◽  
Baljinder Singh ◽  
Tek C. Kalawat ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Imaging Agent ◽  
Preliminary Evaluation ◽  
Infection Imaging ◽  
Technetium 99M ◽  
Orthopedic Infection
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