Donors’ health state the year after peripheral haematopoietic progenitor cell collection: A prospective follow-up study in related and unrelated donors compared to first-time platelet donors

Aim: To evaluate the electrical activity of the myocardium and the radiofrequency (RF) application zone resulting from radiofrequency ablation (RFA) performed at an early age.Material and Methods. A prospective follow-up study included three patients who underwent intracardiac electrophysiological study (EPS) and effective RFA of the tachycardia for the first time at an early age. A reintervention was required in one case 12 years after the procedure and in two cases six years after it due to recurrent and new-onset arrhythmias. During the reintervention, electroanatomical mapping was performed to assess the potential damaging effect of radiofrequency exposure in the area of the first ablation.Results. The intracardiac EPS and amplitude bipolar CARTO-reconstruction of primary ablation area were performed during repeated RFA procedure. The study showed that neither zones with a decrease in the amplitude of electrical signal from the myocardium nor silent electrical zones were present ruling out the cicatricial-sclerotic changes in the myocardium in children in the long-term period after RF exposure.Conclusion. The study showed that no increase in the coagulation necrosis zone in the area of primary ablation occurred during the growth of child when the sparing energy and temperature parameters of RFA and the limited number of RF applications were used. Further research in this area is required.

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Factors associated with institutionalization among home-dwelling patients of Urgent Geriatric Outpatient Clinic: a 3-year follow-up study

European Geriatric Medicine ◽

10.1007/s41999-020-00338-7 ◽

2020 ◽

Vol 11 (5) ◽

pp. 745-751

Author(s):

Marika Salminen ◽

Jonna Laine ◽

Tero Vahlberg ◽

Paula Viikari ◽

Maarit Wuorela ◽

...

Keyword(s):

Standard Deviation ◽

Outpatient Clinic ◽

Older Patients ◽

Cox Regression ◽

Regression Analyses ◽

Factors Associated ◽

Follow Up Study ◽

The Mean ◽

First Time

Abstract Purpose To examine the effect of predictive factors on institutionalization among older patients. Methods The participants were older (aged 75 years or older) home-dwelling citizens evaluated at Urgent Geriatric Outpatient Clinic (UrGeriC) for the first time between the 1st of September 2013 and the 1st of September 2014 (n = 1300). They were followed up for institutionalization for 3 years. Death was used as a competing risk in Cox regression analyses. Results The mean age of the participants was 85.1 years (standard deviation [SD] 5.5, range 75–103 years), and 74% were female. The rates of institutionalization and mortality were 29.9% and 46.1%, respectively. The mean age for institutionalization was 86.1 (SD 5.6) years. According to multivariate Cox regression analyses, the use of home care (hazard ratio 2.43, 95% confidence interval 1.80–3.27, p < 0.001), dementia (2.38, 1.90–2.99, p < 0.001), higher age (≥ 95 vs. 75–84; 1.65, 1.03–2.62, p = 0.036), and falls during the previous 12 months (≥ 2 vs. no falls; 1.54, 1.10–2.16, p = 0.012) significantly predicted institutionalization during the 3-year follow-up. Conclusion Cognitive and/or functional impairment mainly predicted institutionalization among older patients of UrGeriC having health problems and acute difficulties in managing at home.

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Long-term follow up of patients with follicular lymphoma (FL) receiving high dose therapy (HDT) with autologous haematopoietic progenitor cell support at St. Bartholomew’s Hospital (SBH)

Journal of Clinical Oncology ◽

10.1200/jco.2005.23.16_suppl.6568 ◽

2005 ◽

Vol 23 (16_suppl) ◽

pp. 6568-6568

Author(s):

A. J. Davies ◽

J. Apostolidis ◽

I. N. Micallef ◽

S. Montoto ◽

J. Matthews ◽

...

Keyword(s):

Follicular Lymphoma ◽

Progenitor Cell ◽

High Dose ◽

High Dose Therapy ◽

Haematopoietic Progenitor Cell ◽

Dose Therapy ◽

Long Term Follow Up ◽

Cell Support

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Drug-eluting stents or balloon angioplasty for drug-eluting stent-associated restenosis: An observational follow-up study of first-time versus repeated restenosis

Journal of the Saudi Heart Association ◽

10.1016/j.jsha.2016.10.001 ◽

2017 ◽

Vol 29 (2) ◽

pp. 76-83 ◽

Cited By ~ 1

Author(s):

Mohamed Aboel-Kassem F. Abdelmegid ◽

Tarek A.N. Ahmed ◽

Masashi Kato ◽

Kenji Ando ◽

Takenori Domei ◽

...

Keyword(s):

Balloon Angioplasty ◽

Drug Eluting Stents ◽

Drug Eluting Stent ◽

Follow Up Study ◽

Drug Eluting ◽

First Time

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Haploidentical Hematopoietic Cell Transplantation (HCT) Compared with Matched HCT from Family Donors: report of 216 cases.

Blood ◽

10.1182/blood.v104.11.5160.5160 ◽

2004 ◽

Vol 104 (11) ◽

pp. 5160-5160

Author(s):

Daopei Lu ◽

Wei Han ◽

Lujia Dong ◽

Xiaojun Huang ◽

Kaiyan Liu ◽

...

Keyword(s):

High Risk ◽

Hematopoietic Cell Transplantation ◽

Chronic Gvhd ◽

Great Majority ◽

Post Transplant ◽

Unrelated Donors ◽

Haploidentical Hematopoietic Cell Transplantation ◽

First Time ◽

Related Mortality

Abstract A total of 216 cases of matched and mismatched-haploidentical HCT from family donors have been performed since May 2002 in our Institute. The purpose of this analysis is to compare the GvHD, relapse rate and their risk factors for complications and survival. The feasibility of the present regimen can then be evaluated. In the arm of mismatched-haploidentical HCT, GIAC regimen (G-CSF priming hematopoietic cells collection; immunosuppression intensified and prolonged; ATG being used; combination use of BM + PB) was used for the first time. It was developed for patients without HLA matched related or unrelated donors. However, in HLA matched HCT, ATG was not used. The two groups were comparable in disease diagnoses, sex, and prophylaxis of GvHD, number of MNC/kg and use of G-CSF post-transplant. The great majority of recruited patients had hematological malignancies. A few were cases of SAA. There were significantly more patients in advanced stage or in high-risk status in mismatched-haploidentical HCT group. After median value of 9(2–260 months follow up, the results are shown in Table 1. Table 1. Survival and causes of Death (2-year Kaplan-Meire Estimates) Characteristics and Outcomes Matched Mismatched-haploidentical No. Of Patients 116 100 Age (yr.) 37 (12–62) 23 (3–52) Status of Patients Standard Risk 86 (74.8%) 44 (44%) High Risk 30 (25.2%) 56 (56%) Days post-transplant ANC>0.5x109/L 16.4 12 Platelets>20x109/L 16.9 17 Acute GvHD <100 days 0-I 48.6% 52% II 38.6% 35% III-IV 12.8% 13% Chronic GvHD 62.5% 63.3% Extensive 18.7% 18.3% Overall survival for 1 year 81.2% 72% Relapse related mortality 5.17% 6% Non-relapse related mortality 11.2% 16% In summary, compared to matched HCT, GIAC regimen for mismatche-haploidentical HCT is sufficiently safe for patients.

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