The Involvement of Corin in the Progression of Diabetic Erectile Dysfunction in a Rat Model by Down-Regulating ANP /NO/cGMP Signal Pathway

2017 ◽  
Vol 118 (8) ◽  
pp. 2325-2332 ◽  
Author(s):  
Jian Wang ◽  
Yuanyuan Mi ◽  
Fenglai Yuan ◽  
Sheng Wu ◽  
Xiaoming You ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Rat Model ◽  
Signal Pathway ◽  
Cgmp Signal

scholarly journals Intracavernous Injection of Autologous Platelet-Rich Plasma Ameliorates Hyperlipidemia-Associated Erectile Dysfunction in a Rat Model

2021 ◽  
Vol 9 (2) ◽  
pp. 100317
Author(s):  
Yun-Ching Huang ◽  
Chun-Te Wu ◽  
Miao-Fen Chen ◽  
Yi-Hung Kuo ◽  
Jhy-Ming Li ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Rat Model ◽  
Platelet Rich Plasma ◽  
Intracavernous Injection ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

MP45-15 EFFECT OF ICARIIN IN COMBINATION WITH DAILY SILDENAFIL ON PENILE ATROPHY AND ERECTILE DYSFUNCTION IN A RAT MODEL OF BILATERAL CAVERNOUS NERVES INJURY

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Yongde Xu ◽  
Yuanyi Wu ◽  
Yong Yang ◽  
Zhongcheng Xin
Keyword(s):  
Erectile Dysfunction ◽  
Rat Model ◽  
Cavernous Nerves

Inhibition of Interleukin‐6 Attenuates Erectile Dysfunction in a Rat Model of Nerve-Sparing Radical Prostatectomy

2011 ◽  
Vol 8 (7) ◽  
pp. 1957-1964 ◽  
Author(s):  
Shinichi Yamashita ◽  
Ryuichi Kato ◽  
Ko Kobayashi ◽  
Shin‐ichi Hisasue ◽  
Yoichi Arai ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Radical Prostatectomy ◽  
Rat Model ◽  
Interleukin 6 ◽  
Nerve Sparing

Celastrol Exerts Cardioprotective Effect in Rheumatoid Arthritis by Inhibiting TLR2/HMGB1 Signaling Pathway-Mediated Autophagy

2021 ◽  
pp. 1-10
Author(s):  
Xiaohong Lu ◽  
Sha Gong ◽  
Xiaojun Wang ◽  
Nan Hu ◽  
Dan Pu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Inflammatory Cytokines ◽  
Rat Model ◽  
Cell Apoptosis ◽  
Signal Pathway ◽  
Index Score ◽  
Cardioprotective Effect ◽  
Rat Cardiomyocytes ◽  
Swelling Degree ◽  
Collagen Iii

<b><i>Objective:</i></b> Rheumatoid arthritis (RA) is a kind of chronic inflammatory disease characterized by the release of inflammatory cytokines and cardiomyocyte apoptosis, which lead to increased riskfor heart diseases. This study aims to explore the possible effect and mechanism of Celastrol on RA induced cardiac impairments in rats. <b><i>Methods:</i></b> Collagen induced RA wistar rat models (CIA) were established for the measurement on secondary foot swelling degree, polyarthritis index score, spleen and thymus index. Pathological morphology was observed using H&amp;E staining. Heart fibrosis was measured after Sirius red staining, while cell apoptosis was determined by TUNEL staining. For in vitro experiments, rat cardiomyocytes were isolated to determine the inflammatory cytokine secretion and cell apoptosis using ELISA and flow cytometry, respectively. Protein expressions of related index and autophagy were detected by Western blot and immunofluorescence. <b><i>Results:</i></b> CIA rat model was successfully established and characterized by severe secondary foot swelling degree, and increased polyarthritis index score and spleen and thymus index. Synovial hyperplasia, disordered cardiomyocytes, cell infiltration and fibrosis were also observed in CIA rat model. Compared with CIA model, Celastrol treatment could suppress the release of inflammatory cytokines, including TNF-α, IL-6, IL-1β, as well as inhibiting the expressions of Bax, cleaved caspase3, collagen I, collagen III and α-SMA. In addition to that, Celastrol treatment can attenuate cell apoptosis and fibrosis of cardiomyocytes and elevate Bcl-2 expression. RA induced cell autophagy can be suppressed by Celastrol through inhibiting the activation of TLR2/HMGB1 signal pathway. <b><i>Conclusion:</i></b> Celastrol can regulate TLR2/HMGB1 signal pathway to suppress autophagy and therefore exert cardioprotective effect in RA.

scholarly journals Effects of Omega-3 Fatty Acids on Erectile Dysfunction in a Rat Model of Atherosclerosis-induced Chronic Pelvic Ischemia

2016 ◽  
Vol 31 (4) ◽  
pp. 585 ◽  
Author(s):  
Ji Sung Shim ◽  
Dae Hee Kim ◽  
Jae Hyun Bae ◽  
Du Geon Moon
Keyword(s):  
Fatty Acids ◽  
Erectile Dysfunction ◽  
Rat Model ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Pelvic Ischemia

164 The Effects of Multiple Adipose-Derived Stem Cell Intracorporeal Injections on Erectile Dysfunction in a Rat Model of Cavernosal Nerve Injury

2018 ◽  
Vol 15 (2) ◽  
pp. S48-S49
Author(s):  
J. Anaissie ◽  
N.M. Haney ◽  
B. Song ◽  
Z. Brabadi ◽  
T. Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Erectile Dysfunction ◽  
Nerve Injury ◽  
Rat Model ◽  
Adipose Derived Stem Cell ◽  
Cavernosal Nerve
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