Efficient synthesis, reactions, and biological activities of new thieno and furopyrazolo[3,4‐ b ]pyrazines and their related heterocycles

2019 ◽  
Vol 67 (4) ◽  
pp. 658-673 ◽  
Author(s):  
Remon M. Zaki ◽  
Adel M. Kamal El‐Dean ◽  
Shaban M. Radwan ◽  
Mokhtar A. Abd ul‐Malik
Keyword(s):  
Biological Activities ◽  
Efficient Synthesis ◽  
Synthesis Reactions

Tetrazoloquinolines: Synthesis, Reactions, and Applications

2020 ◽  
Vol 24 (4) ◽  
pp. 439-464 ◽  
Author(s):  
Rizk E. Khidre ◽  
Tahah A. Ameen ◽  
Mounir A. I. Salem
Keyword(s):  
Carboxylic Acid ◽  
Chemical Reactions ◽  
Sodium Azide ◽  
Biological Activities ◽  
Quinoline Derivatives ◽  
Pharmacological Activities ◽  
Synthesis Reactions ◽  
Intramolecular Cyclocondensation

This review summarizes the synthesis, reactions, and biological activities of tetrazolo[1,5-a]quinoline derivatives. These derivatives were synthesized by several methods such as i) from the reaction of 2-chloroquinoline with sodium azide ii) from diazotization 2-hydrazinylquinoline derivatives, and iii) from intramolecular cyclocondensation of 2-azidoarylidenes. Also, the chemical reactions and pharmacological activities of some tetrazoloquinolines such as tetrazolo[1,5-a]quinoline-4-carbaldehyde, 5-chlorotetrazolo[ 1,5-a]quinoline, 4-(chloromethyl)tetrazolo[1,5-a]quinoline, tetrazolo[1,5- a]quinoline-4-carboxylic acid, and 5-azidotetrazolo[1,5-a]quinoline were discussed.

Metal and Non-Metal Catalysts in the Synthesis of Five-Membered S-Heterocycles

2019 ◽  
Vol 16 (2) ◽  
pp. 258-275 ◽  
Author(s):  
Navjeet Kaur
Keyword(s):  
Organic Synthesis ◽  
Biological Activities ◽  
Reaction Times ◽  
Research Field ◽  
Environmentally Benign ◽  
Metal Catalyst ◽  
Efficient Synthesis ◽  
Heterocyclic Molecules ◽  
The Past ◽  
Harsh Conditions

Background:A wide variety of biological activities are exhibited by N, O and S containing heterocycles and recently, many reports appeared for the synthesis of these heterocycles. The synthesis of heterocycles with the help of metal and non-metal catalyst has become a highly rewarding and important method in organic synthesis. This review article concentrated on the synthesis of S-heterocylces in the presence of metal and non-metal catalyst. The synthesis of five-membered S-heterocycles is described here.Objective:There is a need for the development of rapid, efficient and versatile strategy for the synthesis of heterocyclic rings. Metal, non-metal and organocatalysis involving methods have gained prominence because traditional conditions have disadvantages such as long reaction times, harsh conditions and limited substrate scope.Conclusion:The metal-, non-metal-, and organocatalyst assisted organic synthesis is a highly dynamic research field. For ßthe chemoselective and efficient synthesis of heterocyclic molecules, this protocol has emerged as a powerful route. Various methodologies in the past few years have been pointed out to pursue more sustainable, efficient and environmentally benign procedures and products. Among these processes, the development of new protocols (catalysis), which avoided the use of toxic reagents, are the focus of intense research.

1,4-Diazepines: A Review on Synthesis, Reactions and Biological Significance

2019 ◽  
Vol 16 (5) ◽  
pp. 709-729 ◽  
Author(s):  
Muhammad A. Rashid ◽  
Aisha Ashraf ◽  
Sahibzada S. Rehman ◽  
Shaukat A. Shahid ◽  
Adeel Mahmood ◽  
...  
Keyword(s):  
Biological Activities ◽  
Biological Significance ◽  
Biological Evaluation ◽  
Wide Range ◽  
Pharmaceutical Industries ◽  
Biological Aspects ◽  
Synthetic Routes ◽  
Biological Attributes ◽  
Synthesis Reactions ◽  
Potential Use

Background:1,4-Diazepines are two nitrogen containing seven membered heterocyclic compounds and associated with a wide range of biological activities. Due to its medicinal importance, scientists are actively involved in the synthesis, reactions and biological evaluation of 1,4-diazepines since number of decades.Objective:The primary purpose of this review is to discuss the synthetic schemes and reactivity of 1,4- diazepines. This article also describes biological aspects of 1,4-diazepine derivatives, that can be usefully exploited for the pharmaceutical sector.Conclusion:This review summarizes the abundant literature on synthetic routes, chemical reactions and biological attributes of 1,4-diazepine derivatives. We concluded that 1,4-diazepines have significant importance due to their biological activities like antipsychotic, anxiolytic, anthelmintic, anticonvulsant, antibacterial, antifungal and anticancer. 1,4-diazepine derivatives with significant biological activities could be explored for potential use in the pharmaceutical industries.

ChemInform Abstract: Thioxoquinazolines: Synthesis, Reactions and Biological Activities

ChemInform ◽  
2011 ◽  
Vol 42 (52) ◽  
pp. no-no
Author(s):  
Gamal A. El-Hiti ◽  
Ajaz Hussain ◽  
Amany S. Hegazy ◽  
Mohammad H. Alotaibi
Keyword(s):  
Biological Activities ◽  
Synthesis Reactions

An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester): analogues, biological activities, and comparison with oleanolic acid derivatives

2014 ◽  
Vol 12 (28) ◽  
pp. 5192-5200 ◽  
Author(s):  
Liangfeng Fu ◽  
Qi-Xian Lin ◽  
Karen T. Liby ◽  
Michael B. Sporn ◽  
Gordon W. Gribble
Keyword(s):  
Methyl Ester ◽  
Oleanolic Acid ◽  
Biological Activities ◽  
Efficient Synthesis

An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester).

ChemInform Abstract: An Efficient Synthesis of Benzimidazoles via a Microwave Technique and Evaluation of Their Biological Activities.

ChemInform ◽  
2013 ◽  
Vol 44 (41) ◽  
pp. no-no
Author(s):  
Bahittin Kahveci ◽  
Emre Mentese ◽  
Musa Oezil ◽  
Serdar Uelker ◽  
Murat Ertuerk
Keyword(s):  
Biological Activities ◽  
Efficient Synthesis ◽  
Microwave Technique

Overview on Synthesis, Reactions, Applications, and Biological Activities of Schiff Bases

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Shorouk Mukhtar ◽  
Ashraf Hassan ◽  
Nesrin Morsy ◽  
Taghrid Hafez ◽  
Hamdi Hassaneen ◽  
...  
Keyword(s):  
Schiff Bases ◽  
Biological Activities ◽  
Synthesis Reactions

An Efficient Synthesis of Phthalimides and Their Biological Activities

2020 ◽  
pp. 1-8
Author(s):  
H. Jelali ◽  
L. Mansour ◽  
E. Deniau ◽  
M. Sauthier ◽  
N. Hamdi
Keyword(s):  
Biological Activities ◽  
Efficient Synthesis

Thioxoquinazolines: synthesis, reactions and biological activities

2011 ◽  
Vol 32 (4) ◽  
pp. 361-395 ◽  
Author(s):  
Gamal A. El-Hiti ◽  
Ajaz Hussain ◽  
Amany S. Hegazy ◽  
Mohammad H. Alotaibi
Keyword(s):  
Biological Activities ◽  
Synthesis Reactions
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