scholarly journals ITGA5 is an independent prognostic biomarker and potential therapeutic target for laryngeal squamous cell carcinoma

2022 ◽  
Author(s):  
Chongchang Zhou ◽  
Yiming Shen ◽  
Zhengyu Wei ◽  
Zhisen Shen ◽  
Ming Tang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Therapeutic Target ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Prognostic Biomarker ◽  
Potential Therapeutic Target

FGFR1 as a prognostic biomarker and potential therapeutic target in head and neck squamous cell carcinoma.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 6057-6057
Author(s):  
Stefan M. Willems ◽  
Koos Koole ◽  
Diede Brunen ◽  
Pauline MD van Kempen ◽  
Rob Noorlag ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Therapeutic Target ◽  
Prognostic Biomarker ◽  
Neck Squamous Cell Carcinoma ◽  
Potential Therapeutic Target

Potential therapeutic target and independent prognostic marker of TROP2 in laryngeal squamous cell carcinoma

Head & Neck ◽  
2012 ◽  
pp. n/a-n/a ◽  
Author(s):  
Hao Wu ◽  
Huiming Xu ◽  
Shu Zhang ◽  
Xudong Wang ◽  
Huijun Zhu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Prognostic Marker ◽  
Squamous Cell ◽  
Therapeutic Target ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Potential Therapeutic Target ◽  
Independent Prognostic Marker

scholarly journals SHISA3Promoter Methylation Is a Potential Diagnostic and Prognostic Biomarker for Laryngeal Squamous Cell Carcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Zhisen Shen ◽  
Chongchang Zhou ◽  
Jinyun Li ◽  
Dong Ye ◽  
Hongxia Deng ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Promoter Methylation ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Prognostic Biomarker ◽  
Promoter Hypermethylation ◽  
Luciferase Reporter ◽  
Regulatory Function ◽  
Qrt Pcr

The purpose of this study was to evaluate the contribution ofSHISA3promoter methylation to laryngeal squamous cell carcinoma (LSCC).SHISA3promoter methylation status and expression were determined using methylation-specific polymerase chain reaction (MSP) and quantitative real-time PCR (qRT-PCR) in 93 paired LSCC and adjacent normal tissues, respectively. Furthermore, the regulatory function of theSHISA3promoter fragment was analyzed using a luciferase reporter assay. The results reveal that there is a significant increase inSHISA3methylation in LSCC tissues compared with corresponding nontumor tissuesP=4.58E-12. The qRT-PCR results show a significant association betweenSHISA3methylation and expression in LSCCP=1.67E-03. In addition, the area under the receiver operating characteristic curve was 0.91. Consequently, a log-rank test and multivariate Cox analysis suggest thatSHISA3promoter hypermethylation is a predictor of poor overall survival for LSCC (log-rankP= 0.024; HR = 2.71; 95% CI = 1.024–7.177;P= 0.047). The results indicate thatSHISA3promoter hypermethylation might increase the risk of LSCC through regulation of gene expression and is a potential diagnostic and prognostic biomarker for LSCC.

Cell division cycle 7 is a potential therapeutic target in oral squamous cell carcinoma and is regulated by E2F1

2018 ◽  
Vol 96 (6) ◽  
pp. 513-525 ◽  
Author(s):  
Shufang Jin ◽  
Hailong Ma ◽  
Wenyi Yang ◽  
Houyu Ju ◽  
Lizhen Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Division ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Therapeutic Target ◽  
Cell Division Cycle ◽  
Potential Therapeutic Target ◽  
Cell Division Cycle 7

scholarly journals MicroRNA-204-5p is a tumor suppressor and potential therapeutic target in head and neck squamous cell carcinoma

Theranostics ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 1433-1453 ◽  
Author(s):  
Zehang Zhuang ◽  
Pei Yu ◽  
Nan Xie ◽  
Yue Wu ◽  
Haichao Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Suppressor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Therapeutic Target ◽  
Neck Squamous Cell Carcinoma ◽  
Potential Therapeutic Target

scholarly journals Comparative Secretome Analysis of Epithelial and Mesenchymal Subpopulations of Head and Neck Squamous Cell Carcinoma Identifies S100A4 as a Potential Therapeutic Target

2013 ◽  
Vol 12 (12) ◽  
pp. 3778-3792 ◽  
Author(s):  
Kati Rasanen ◽  
Sira Sriswasdi ◽  
Alexander Valiga ◽  
Hsin-Yao Tang ◽  
Gao Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Therapeutic Target ◽  
Neck Squamous Cell Carcinoma ◽  
Potential Therapeutic Target ◽  
Secretome Analysis

scholarly journals G1/S-specific Cyclin-D1 Might be a Prognostic Biomarker for Patients with Laryngeal Squamous Cell Carcinoma

2012 ◽  
Vol 13 (5) ◽  
pp. 2133-2137 ◽  
Author(s):  
Ying-Yao Zhang ◽  
Zhi-Na Xu ◽  
Jun-Xi Wang ◽  
Dong-Min Wei ◽  
Xin-Liang Pan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cyclin D1 ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Prognostic Biomarker
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