Dopamine regulates cell cycle regulatory proteins via cAMP, Ca2+/PKC, MAPKs, and NF-κB in mouse embryonic stem cells

2006 ◽  
Vol 208 (2) ◽  
pp. 399-406 ◽  
Author(s):  
Min Young Lee ◽  
Jung Sun Heo ◽  
Ho Jae Han
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Regulatory Proteins ◽  
Cell Cycle Regulatory Proteins

Alteration of gene expression profile in mouse embryonic stem cells and neural differentiation deficits by ethephon

2020 ◽  
Vol 39 (11) ◽  
pp. 1518-1527
Author(s):  
S Mohammadi Nejad ◽  
M Hodjat ◽  
SA Mousavi ◽  
M Baeeri ◽  
MA Rezvanfar ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Neural Differentiation ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Differentiation Potential

Ethephon, a member of the organophosphorus compounds, is one of the most widely used plant growth regulators for artificial ripening. Although million pounds of this chemical is being used annually, the knowledge regarding its molecular toxicity is yet not sufficient. The purpose of this study was to evaluate the potential developmental toxicity of ethephon using embryonic stem cell model. The mouse embryonic stem cells (mESCs) were exposed to various concentrations of ethephon and the viability, cell cycle alteration and changes in the gene expression profile were evaluated using high-throughput RNA sequencing. Further, the effect of ethephon on neural differentiation potential was examined. The results showed that ethephon at noncytotoxic doses induced cell cycle arrest in mESCs. Gene ontology enrichment analysis showed that terms related to cell fate and organismal development, including neuron fate commitment, embryo development and cardiac cell differentiation, were markedly enriched in ethephon-treated cells. Neural induction of mESCs in the presence of ethephon was inhibited and the expression of neural genes was decreased in differentiated cells. Results obtained from this work clearly demonstrate that ethephon affects the gene expression profile of undifferentiated mESCs and prevents neural differentiation. Therefore, more caution against the frequent application of ethephon is advised.

The miR-290-295 cluster promotes pluripotency maintenance by regulating cell cycle phase distribution in mouse embryonic stem cells

2011 ◽  
Vol 81 (1) ◽  
pp. 11-24 ◽  
Author(s):  
Zsuzsanna Lichner ◽  
Emőke Páll ◽  
Andrea Kerekes ◽  
Éva Pállinger ◽  
Pouneh Maraghechi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Phase Distribution ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Cell Cycle Phase ◽  
Cycle Phase ◽  
Cell Cycle Phase Distribution ◽  
Pluripotency Maintenance

scholarly journals Rad51 Regulates Cell Cycle Progression by Preserving G2/M Transition in Mouse Embryonic Stem Cells

2014 ◽  
Vol 23 (22) ◽  
pp. 2700-2711 ◽  
Author(s):  
Sang-Wook Yoon ◽  
Dae-Kwan Kim ◽  
Keun Pil Kim ◽  
Kyung-Soon Park
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Cell Cycle Progression ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Cycle Progression

scholarly journals Cell cycle dynamics of mouse embryonic stem cells in the ground state and during transition to formative pluripotency

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ariel Waisman ◽  
Federico Sevlever ◽  
Martín Elías Costa ◽  
María Soledad Cosentino ◽  
Santiago G. Miriuka ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Ground State ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Cell Cycle Dynamics

Analysis of the Cell Cycle in Mouse Embryonic Stem Cells

2003 ◽  
pp. 27-33 ◽  
Author(s):  
Pierre Savatier ◽  
Hélène Lapillonne ◽  
Ludmila Jirmanova ◽  
Luigi Vitelli ◽  
Jacques Samarut
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells

scholarly journals Cell Cycle and Developmental Regulations of Replication Factors in Mouse Embryonic Stem Cells

2005 ◽  
Vol 280 (13) ◽  
pp. 12976-12987 ◽  
Author(s):  
Hiroko Fujii-Yamamoto ◽  
Jung Min Kim ◽  
Ken-ichi Arai ◽  
Hisao Masai
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Replication Factors
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