miR-19b-3p induces cell proliferation and reduces heterochromatin-mediated senescence through PLZF in goat male germline stem cells

2017 ◽  
Vol 233 (6) ◽  
pp. 4652-4665 ◽  
Author(s):  
John Clotaire Daguia Zambe ◽  
Yuanxin Zhai ◽  
Zhe Zhou ◽  
Xiaomi Du ◽  
Yudong Wei ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Germline Stem Cells ◽  
Male Germline ◽  
Male Germline Stem Cells

scholarly journals Centrosome misorientation mediates slowing of the cell cycle under limited nutrient conditions in Drosophila male germline stem cells

2012 ◽  
Vol 23 (8) ◽  
pp. 1524-1532 ◽  
Author(s):  
Therese M. Roth ◽  
C.-Y. Ason Chiang ◽  
Mayu Inaba ◽  
Hebao Yuan ◽  
Viktoria Salzmann ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Germline Stem Cells ◽  
Self Renewal ◽  
Stem Cell Regulation ◽  
Male Germline ◽  
Male Germline Stem Cells ◽  
Nutrient Conditions

Drosophila male germline stem cells (GSCs) divide asymmetrically, balancing self-renewal and differentiation. Although asymmetric stem cell division balances between self-renewal and differentiation, it does not dictate how frequently differentiating cells must be produced. In male GSCs, asymmetric GSC division is achieved by stereotyped positioning of the centrosome with respect to the stem cell niche. Recently we showed that the centrosome orientation checkpoint monitors the correct centrosome orientation to ensure an asymmetric outcome of the GSC division. When GSC centrosomes are not correctly oriented with respect to the niche, GSC cell cycle is arrested/delayed until the correct centrosome orientation is reacquired. Here we show that induction of centrosome misorientation upon culture in poor nutrient conditions mediates slowing of GSC cell proliferation via activation of the centrosome orientation checkpoint. Consistently, inactivation of the centrosome orientation checkpoint leads to lack of cell cycle slowdown even under poor nutrient conditions. We propose that centrosome misorientation serves as a mediator that transduces nutrient information into stem cell proliferation, providing a previously unappreciated mechanism of stem cell regulation in response to nutrient conditions.

scholarly journals Previously claimed male germline stem cells from porcine testis are actually progenitor Leydig cells

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Yinshan Bai ◽  
Cui Zhu ◽  
Meiying Feng ◽  
Hengxi Wei ◽  
Li Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Leydig Cells ◽  
Germline Stem Cells ◽  
Male Germline ◽  
Male Germline Stem Cells ◽  
Porcine Testis

scholarly journals High telomerase is a hallmark of undifferentiated spermatogonia and is required for maintenance of male germline stem cells

2015 ◽  
Vol 29 (23) ◽  
pp. 2420-2434 ◽  
Author(s):  
Matthew F. Pech ◽  
Alina Garbuzov ◽  
Kazuteru Hasegawa ◽  
Meena Sukhwani ◽  
Ruixuan J. Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Germline Stem Cells ◽  
Male Germline ◽  
Male Germline Stem Cells

scholarly journals Functional Assessment of Self-Renewal Activity of Male Germline Stem Cells Following Cytotoxic Damage and Serial Transplantation1

2003 ◽  
Vol 68 (5) ◽  
pp. 1801-1807 ◽  
Author(s):  
Mito Kanatsu-Shinohara ◽  
Shinya Toyokuni ◽  
Takeshi Morimoto ◽  
Shigeyuki Matsui ◽  
Tasuku Honjo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Functional Assessment ◽  
Germline Stem Cells ◽  
Self Renewal ◽  
Male Germline ◽  
Male Germline Stem Cells
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