scholarly journals Tucatinib Inhibits Renal Transporters OCT2 and MATE Without Impacting Renal Function in Healthy Subjects

2020 ◽  
Author(s):  
Ariel R. Topletz‐Erickson ◽  
Anthony J. Lee ◽  
JoAl G. Mayor ◽  
Evelyn L. Rustia ◽  
Layth I. Abdulrasool ◽  
...  
Keyword(s):  
Renal Function ◽  
Healthy Subjects ◽  
Renal Transporters

scholarly journals Circadian rhythms in systemic hemodynamics and renal function in healthy subjects and patients with nephrotic syndrome

2001 ◽  
Vol 59 (5) ◽  
pp. 1873-1880 ◽  
Author(s):  
Albertus J. Voogel ◽  
Marion G. Koopman ◽  
Augustinus A.M. Hart ◽  
Gert A. Van Montfrans ◽  
Lambertus Arisz
Keyword(s):  
Renal Function ◽  
Nephrotic Syndrome ◽  
Circadian Rhythms ◽  
Healthy Subjects ◽  
Systemic Hemodynamics

An open-label study to determine the pharmacokinetics and safety of migalastat HCl in subjects with impaired renal function and healthy subjects with normal renal function

2014 ◽  
Vol 4 (4) ◽  
pp. 256-261 ◽  
Author(s):  
Franklin K. Johnson ◽  
Paul N. Mudd ◽  
Tara DiMino ◽  
Jennie Vosk ◽  
Sheela Sitaraman ◽  
...  
Keyword(s):  
Renal Function ◽  
Normal Renal Function ◽  
Healthy Subjects ◽  
Impaired Renal Function ◽  
Open Label ◽  
Open Label Study ◽  
Label Study

scholarly journals Longitudinal Study of the Decline in Renal Function in Healthy Subjects

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0129036 ◽  
Author(s):  
Mika Baba ◽  
Takuro Shimbo ◽  
Masaru Horio ◽  
Masahiko Ando ◽  
Yoshinari Yasuda ◽  
...  
Keyword(s):  
Renal Function ◽  
Longitudinal Study ◽  
Healthy Subjects

scholarly journals Absence of age and gender effects on the pharmacokinetics of a single 500-milligram oral dose of levofloxacin in healthy subjects.

1997 ◽  
Vol 41 (7) ◽  
pp. 1562-1565 ◽  
Author(s):  
S C Chien ◽  
A T Chow ◽  
J Natarajan ◽  
R R Williams ◽  
F A Wong ◽  
...  
Keyword(s):  
Renal Function ◽  
Healthy Subjects ◽  
Age Groups ◽  
The Elderly ◽  
Gender Effects ◽  
Pharmacokinetic Parameters ◽  
Age And Gender ◽  
Male And Female ◽  
Young Males ◽  
And Gender

The influence of age and gender on the pharmacokinetics of levofloxacin in healthy subjects receiving a single oral 500-mg dose of levofloxacin was investigated in this parallel design study. Six young males (aged 18 to 40 years), six elderly males (aged > or = 65 years), six young females (aged 18 to 40 years), and six elderly females (aged > or = 65 years) were enrolled and completed the study. The study reveals that the bioavailability (rate and extent) of levofloxacin was not affected by either age or gender. In both age (young and elderly) and gender (male and female) groups of subjects, peak concentrations in plasma were reached at approximately 1.5 h after dosing; renal clearance of levofloxacin accounted for approximately 77% of total body clearance, and approximately 76% of the administered dose was recovered unchanged in urine over the 36 h of collection. The apparent differences in the calculated pharmacokinetic parameters for levofloxacin between the age groups (young versus elderly) and between the gender groups (males versus females) could be explained by differences in renal function among the subjects. A single dose of 500 mg of levofloxacin administered orally to both young and old, male and female healthy subjects was found to be safe and well tolerated. As the differences in levofloxacin kinetics between the young and the elderly or the males and the females are limited and are mainly related to the renal function of the subjects, dose adjustment based on age or gender alone is not necessary.

Icatibant has no impact on renal function in healthy subjects

2004 ◽  
Vol 75 (2) ◽  
pp. P57
Author(s):  
P Rousso
Keyword(s):  
Renal Function ◽  
Healthy Subjects

Serum Concentration of Growth Differentiation Factor-15 Is Independently Associated with Global Platelet Function and Higher Fibrinogen Values in Adult Healthy Subjects

2017 ◽  
Vol 43 (06) ◽  
pp. 621-628 ◽  
Author(s):  
Gian Salvagno ◽  
Elisa Danese ◽  
Giorgio Brocco ◽  
Matteo Gelati ◽  
Martina Montagnana ◽  
...  
Keyword(s):  
Renal Function ◽  
Serum Concentration ◽  
Platelet Function ◽  
Healthy Subjects ◽  
Cardiovascular Events ◽  
Linear Regression Analysis ◽  
Univariate Analysis ◽  
Plasma Fibrinogen ◽  
Growth Differentiation Factor 15 ◽  
Differentiation Factor

AbstractGrowth differentiation factor-15 (GDF-15) has recently emerged as a strong and independent predictor of cardiovascular events and mortality. However, the pathophysiological mechanisms underlying this important association remain speculative. This study was aimed to investigate the potential associations between the serum concentration of GDF-15 and clinical or laboratory parameters in a population of ostensibly healthy subjects. The study population consisted of 44 healthy volunteers enrolled from the laboratory staff (14 males and 30 females; mean age, 47 ± 11 years), who had their blood collected for assessing complete blood cell count, GDF-15, serum creatinine, albumin, cardiac troponin T, galectin-3, routine coagulation tests, D-dimer, von Willebrand factor, and platelet function testing using platelet function analyzer-100. In univariate analysis, serum GDF-15 was found to be positively associated with age and plasma fibrinogen, and negatively associated with renal function and collagen-epinephrine (CEPI). In multiple linear regression analysis, serum GDF-15 remained significantly associated with renal function, CEPI, and plasma fibrinogen. Healthy subjects with GDF-15 above the median value had a twofold probability of displaying shorter CEPI closure times. Taken together, these results suggest that higher serum values of GDF-15 may be associated with overall global platelet hyperactivity and increased plasma fibrinogen, so providing another plausible explanation for the association between GDF-15, cardiovascular events, and mortality.

Dietary Composition and Renal Function in Healthy Subjects

Nephron ◽  
1987 ◽  
Vol 46 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Martin J. Wiseman ◽  
Rosemary Hunt ◽  
Angela Goodwin ◽  
Jorge L. Gross ◽  
Harry Keen ◽  
...  
Keyword(s):  
Renal Function ◽  
Healthy Subjects ◽  
Dietary Composition

scholarly journals Effect of dronedarone on renal function in healthy subjects

2005 ◽  
Vol 77 (2) ◽  
pp. P10-P10 ◽  
Author(s):  
Y TSCHUPPERT ◽  
T BUCLIN ◽  
L ROTHUIZEN ◽  
L DECOSTERD ◽  
M APPENZELLER ◽  
...  
Keyword(s):  
Renal Function ◽  
Healthy Subjects

Effect of carteolol on renal function in healthy subjects and patients with hypertension

1989 ◽  
Vol 36 (1) ◽  
pp. 83-86 ◽  
Author(s):  
K. Tabei ◽  
H. Furuya ◽  
Y. Asano ◽  
S. Hosoda
Keyword(s):  
Renal Function ◽  
Healthy Subjects

Effects of short IV infusions of DT-009, a novel adenosine (A?) receptor agonist, on renal function in healthy subjects

2005 ◽  
Vol 77 (2) ◽  
pp. P58-P58
Author(s):  
J VENITZ ◽  
D SICA ◽  
R TOWNSEND ◽  
M DESSIMOZ
Keyword(s):  
Renal Function ◽  
Healthy Subjects ◽  
Receptor Agonist
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