Thyroid hormones in trout reproduction: Enhancement of gonadotropin-releasing hormone analogue and partially purified salmon gonadotropin-induced ovarian maturation in vivo and in vitro

1989 ◽  
Vol 250 (2) ◽  
pp. 188-195 ◽  
Author(s):  
Craig V. Sullivan ◽  
Melinda G. Bernard ◽  
Akihiko Hara ◽  
Walton W. Dickhoff
Keyword(s):  
Thyroid Hormones ◽  
Gonadotropin Releasing Hormone ◽  
Ovarian Maturation ◽  
Hormone Analogue ◽  
Releasing Hormone ◽  
Gonadotropin Releasing Hormone Analogue

The relative success of gonadotropin-releasing hormone analogue, clomiphene citrate, and gonadotropin in 1,099 cycles of in vitro fertilization

1992 ◽  
Vol 58 (5) ◽  
pp. 986-990 ◽  
Author(s):  
Jehoshua Dor ◽  
Izhar Ben-Shlomo ◽  
David Levran ◽  
Edwina Rudak ◽  
Michal Yunish ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Clomiphene Citrate ◽  
Gonadotropin Releasing Hormone ◽  
Hormone Analogue ◽  
Vitro Fertilization ◽  
Releasing Hormone ◽  
Gonadotropin Releasing Hormone Analogue ◽  
Relative Success

Evaluation of the Binding Affinity of a Gonadotropin-Releasing Hormone Analogue (GnRH-a) Buserelin through In Silico and In Vivo testing in Clarias magur

2021 ◽  
Vol 18 ◽  
Author(s):  
Mukesh Kumar ◽  
Mukunda Goswami ◽  
Sunil Kumar Nayak ◽  
Gireesh-Babu P. ◽  
Aparna Chaudhari
Keyword(s):  
Binding Affinity ◽  
In Silico ◽  
Docking Studies ◽  
Gnrh Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Hormone Analogue ◽  
Releasing Hormone ◽  
Gonadotropin Releasing Hormone Analogue ◽  
In Vivo Testing

Aim: To evaluate the binding affinity and biological potency of gonadotropin releasing hormone analogue (GnRHa) Buserelin (‎C60H86N16O13) based on in silico and in vivo testing for induced breeding in Clarias magur. Background: Many attempts have been made to induce C. magur but encouraging results have not yet been achieved. Hence, it is the need of the hour to find out more potent analogues or other bio-molecules for induced breeding in C. magur to facilitate sustainable aquaculture. Objective: To determine the binding affinity of C. magur GnRH receptor through in silico and its validation for induced breeding of C. magur. Methods: Buserelin (‎C60H86N16O13) was selected as the potential GnRHa after screening several peptides for their binding energy with the C. magur GnRH receptor. The induced breeding trial was set up at ICAR-CIFE Powarkheda Centre, M.P. India, and Buserelin was administered in different doses to the brooders along with the dopamine inhibitor domperidone. The standard treatment with the commercial salmon GnRH (sGnRH) analogue Ovaprim® (Syndel, USA) was used as the control. Results: The 3-D structure of C. magur GnRH receptor was generated using MODELLER software. Molecular docking studies revealed the binding preference of the receptor as chicken (c) GnRH-II > Buserelin > sGnRH > catfish (cf) GnRH > human (m) GnRH. Though Buserelin showed better binding affinity compared to sGnRH, induced breeding experiments with magur showed similar performance of the ligands at the equivalent dose of 20 µg/kg B.W., but the spontaneous release of milt from the males was not obsereved in both the cases. Significantly better reproductive parameters were recorded with Buserelin at the dose of 30 µg/kg B.W. Conclusion: The study revealed that that the GnRHa Buserelin can be used as an effective inducing agent for breeding in C. magur.

Sustained hormone release. I. Characteristics of in vitro release of gonadotropin-releasing hormone analogue (GnRH-A) from pellets

Aquaculture ◽  
1988 ◽  
Vol 74 (1-2) ◽  
pp. 75-86 ◽  
Author(s):  
Nancy M. Sherwood ◽  
L.W. Crim ◽  
J. Carolsfeld ◽  
Sandra M. Walters
Keyword(s):  
In Vitro Release ◽  
Gonadotropin Releasing Hormone ◽  
Hormone Release ◽  
Hormone Analogue ◽  
Releasing Hormone ◽  
Gonadotropin Releasing Hormone Analogue ◽  
Vitro Release

Short-term effects of gonadotropin-releasing hormone analogue treatment on leptin, ghrelin and peptide YY in girls with central precocious puberty

2021 ◽  
Vol 34 (4) ◽  
pp. 479-484
Author(s):  
Piyathida Wijarn ◽  
Preamrudee Poomthavorn ◽  
Patcharin Khlairit ◽  
Sarunyu Pongratanakul ◽  
Laor Chailurkit ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Peptide Yy ◽  
Central Precocious Puberty ◽  
Gonadotropin Releasing Hormone ◽  
Hormone Analogue ◽  
Short Term ◽  
Serum Leptin ◽  
Releasing Hormone ◽  
Gonadotropin Releasing Hormone Analogue ◽  
Before And After

Abstract Objectives To determine appetite-regulating hormone levels in girls with central precocious puberty (CPP) before and after 20 weeks of gonadotropin-releasing hormone analogue (GnRH-A) treatment. Methods Eighteen newly diagnosed CPP girls were enrolled. Body composition measured by bioelectrical impedance analysis and GnRH-A test were performed with fasting serum leptin, ghrelin and peptide YY (PYY) measurements at baseline (before) and after 20 weeks of GnRH-A treatment. Results Following GnRH-A treatment, all patients had prepubertal gonadotropin and estradiol levels. Mean (SD) fat mass index (FMI) was significantly increased from 4.5 (1.7) to 5.0 (1.8) kg/m2 after treatment. Also, median (IQR) serum leptin level was significantly increased from 6.9 (4.2–8.6) to 7.4 (5.3–13.1) ng/mL. FMI had a positive correlation with serum leptin level (r=0.64, p=0.004). In contrast, no significant changes of serum ghrelin and PYY levels were observed. Conclusions Decreased estrogen following short-term GnRH-A treatment in CPP girls may cause an increase in appetite and consequently an elevation of FMI. Increased serum leptin may be a result of having increased FMI secondary to an increase in appetite.

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