Potential role for the sorbitol pathway in the meiotic dysfunction exhibited by oocytes from diabetic mice

2004 ◽  
Vol 301A (5) ◽  
pp. 439-448 ◽  
Author(s):  
Shannondoah A. Colton ◽  
Stephen M. Downs
Keyword(s):  
Potential Role ◽  
Diabetic Mice ◽  
Sorbitol Pathway

Novel implications of the potential role of selenium on antioxidant status in streptozotocin-induced diabetic mice

1998 ◽  
Vol 52 (2) ◽  
pp. 89-95 ◽  
Author(s):  
B Mukherjee ◽  
S Anbazhagan ◽  
A Roy ◽  
R Ghosh ◽  
M Chatterjee
Keyword(s):  
Antioxidant Status ◽  
Potential Role ◽  
Diabetic Mice

scholarly journals Outcome of Acute Renal Injury in Diabetic Mice with Experimental Endotoxemia: Role of Hypoxia-Inducible Factor-1α

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
A. Ortega ◽  
A. Fernández ◽  
M. I. Arenas ◽  
P. López-Luna ◽  
C. Muñóz-Moreno ◽  
...  
Keyword(s):  
Renal Injury ◽  
Potential Role ◽  
Glycated Albumin ◽  
Hypoxia Inducible Factor ◽  
Diabetic Mice ◽  
Acute Renal Injury ◽  
Vascular Endothelium Growth Factor ◽  
Experimental Endotoxemia ◽  
Streptozotocin Induced Diabetes

The role of diabetic nephropathy in the outcome of acute renal injury (AKI) is not well defined. Herein we evaluate the outcome of lipopolysaccharide- (LPS-) induced AKI in streptozotocin-induced diabetes, as well as the potential role of Hypoxia Inducible Factor (HIF-1α) in this condition. Although 6 h after LPS injection all mice developed a decrease in renal function, proteinuric diabetic mice showed a better recovery of this parameter throughout the study (72 h). Both HIF-1αand vascular endothelium growth factor (VEGF) were found to be upregulated in diabetic mice. After LPS injection, all animals showed an upregulation of these factors, although it was higher in the diabetic group. Glycated albumin (GA) was found to upregulate HIF-1αin HK-2 cells, which resulted in increased production of VEGF. Interestingly, LPS cooperated with GA to induce HIF-1αupregulation. In conclusion, diabetic mice display a better recovery of AKI after experimental endotoxemia. Moreover, these animals showed an increased expression of both HIF-1αand VEGF that was reproduced by incubating renal cells with GA. Since VEGF is considered a survival factor for tubular cells, our findings suggest that diabetes displays HIF-1αupregulation that might function as a “precondition state” offering protection from endotoxic AKI.

scholarly journals TP63 Is Significantly Upregulated in Diabetic Kidney

2021 ◽  
Vol 22 (8) ◽  
pp. 4070
Author(s):  
Sitai Liang ◽  
Bijaya K. Nayak ◽  
Kristine S. Vogel ◽  
Samy L. Habib
Keyword(s):  
Glucose Uptake ◽  
Potential Role ◽  
Diabetic Mice ◽  
Wild Type ◽  
Over Expression ◽  
Normal Glucose ◽  
Proximal Tubular ◽  
Mrna And Protein Expression ◽  
Amp Activated Protein Kinase

The role of tumor protein 63 (TP63) in regulating insulin receptor substrate 1 (IRS-1) and other downstream signal proteins in diabetes has not been characterized. RNAs extracted from kidneys of diabetic mice (db/db) were sequenced to identify genes that are involved in kidney complications. RNA sequence analysis showed more than 4- to 6-fold increases in TP63 expression in the diabetic mice’s kidneys, compared to wild-type mice at age 10 and 12 months old. In addition, the kidneys from diabetic mice showed significant increases in TP63 mRNA and protein expression compared to WT mice. Mouse proximal tubular cells exposed to high glucose (HG) for 48 h showed significant decreases in IRS-1 expression and increases in TP63, compared to cells grown in normal glucose (NG). When TP63 was downregulated by siRNA, significant increases in IRS-1 and activation of AMP-activated protein kinase (AMPK (p-AMPK-Th172)) occurred under NG and HG conditions. Moreover, activation of AMPK by pretreating the cells with AICAR resulted in significant downregulation of TP63 and increased IRS-1 expression. Ad-cDNA-mediated over-expression of tuberin resulted in significantly decreased TP63 levels and upregulation of IRS-1 expression. Furthermore, TP63 knockdown resulted in increased glucose uptake, whereas IRS-1 knockdown resulted in a decrease in the glucose uptake. Altogether, animal and cell culture data showed a potential role of TP63 as a new candidate gene involved in regulating IRS-1 that may be used as a new therapeutic target to prevent kidney complications in diabetes.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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