An Efficient and Scalable Synthesis of Isodesmosine

Author(s):  
Aikan Gupta ◽  
Yogesh Sharma ◽  
Ganesh P. Pawar ◽  
Ashish ◽  
Deepak Nihalani ◽  
...  
Keyword(s):  
2019 ◽  
Author(s):  
Merlin Kleoff ◽  
Johannes Schwan ◽  
Lisa Boeser ◽  
Bence Hartmayer ◽  
Mathias Christmann ◽  
...  

A scalable access to functionalized 1,1’- and 1,2-ferrocenyl azides has been realized in flow. By halogen‒lithium exchange of ferrocenyl halides and subsequent reaction with tosyl azide, a variety of functionalized ferrocenyl azides was obtained in high yields. To allow a scalable preparation of these potentially explosive compounds, an efficient flow protocol was developed accelerating the reaction time to minutes and circumventing accumulation of potentially hazardous intermediates. Switching from homogeneous to triphasic flow amidst process was key for handling a heterogeneous reaction mixture formed after a heated reactor section. The corresponding and synthetically versatile ferrocenyl amines were then prepared by a reliable reduction process.


Author(s):  
Myung Sik Choi ◽  
Han Gil Na ◽  
Gyu Sam Shim ◽  
Jae Hee Cho ◽  
Min Young Kim ◽  
...  

2021 ◽  
Vol 9 (1) ◽  
pp. 2170011
Author(s):  
Dario M. De Carolis ◽  
Dragoljub Vrankovic ◽  
Samira A. Kiefer ◽  
Enrico Bruder ◽  
Michael Thomas Dürrschnabel ◽  
...  

2010 ◽  
Vol 57 (12) ◽  
pp. 3472-3476 ◽  
Author(s):  
Yanjie Wang ◽  
Congqin Miao ◽  
Bo-chao Huang ◽  
Jing Zhu ◽  
Wei Liu ◽  
...  
Keyword(s):  

Author(s):  
Pinaki Ranadive ◽  
Zachary Blanchette ◽  
Alexander Spanos ◽  
J. Will Medlin ◽  
Nicholas Brunelli
Keyword(s):  

2020 ◽  
Vol 1 (12) ◽  
pp. 100277
Author(s):  
Warren C. Chan ◽  
James J. La Clair ◽  
Brian León ◽  
Kelsey A. Trieger ◽  
Martijn Q. Slagt ◽  
...  
Keyword(s):  

ACS Nano ◽  
2021 ◽  
Author(s):  
Haiyu Qiao ◽  
Mahmoud Tamadoni Saray ◽  
Xizheng Wang ◽  
Shaomao Xu ◽  
Gang Chen ◽  
...  

ACS Nano ◽  
2020 ◽  
Vol 14 (9) ◽  
pp. 11548-11557
Author(s):  
Seungkyu Park ◽  
Jaekyung Sung ◽  
Sujong Chae ◽  
Jaehyung Hong ◽  
Taeyong Lee ◽  
...  

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