scholarly journals Hydrogen sulphide production by bottom-fermenting yeast is related to nitrogen starvation signalling

2013 ◽  
Vol 119 (4) ◽  
pp. 228-236 ◽  
Author(s):  
Tomoo Ogata
2019 ◽  
Vol 20 (10) ◽  
pp. 2550 ◽  
Author(s):  
Alida Spalloni ◽  
Viviana Greco ◽  
Giulia Ciriminna ◽  
Victor Corasolla Carregari ◽  
Federica Marini ◽  
...  

A number of factors can trigger amyotrophic lateral sclerosis (ALS), although its precise pathogenesis is still uncertain. In a previous study done by us, poisonous liquoral levels of hydrogen sulphide (H2S) in sporadic ALS patients were reported. In the same study very high concentrations of H2S in the cerebral tissues of the familial ALS (fALS) model of the SOD1G93A mouse, were measured. The objective of this study was to test whether decreasing the levels of H2S in the fALS mouse could be beneficial. Amino-oxyacetic acid (AOA)—a systemic dual inhibitor of cystathionine-β-synthase and cystathionine-γ lyase (two key enzymes in the production of H2S)—was administered to fALS mice. AOA treatment decreased the content of H2S in the cerebral tissues, and the lifespan of female mice increased by approximately ten days, while disease progression in male mice was not affected. The histological evaluation of the spinal cord of the females revealed a significant increase in GFAP positivity and a significant decrease in IBA1 positivity. In conclusion, the results of the study indicate that, in the animal model, the inhibition of H2S production is more effective in females. The findings reinforce the need to adequately consider sex as a relevant factor in ALS.


2012 ◽  
Vol 121 ◽  
pp. 419-424 ◽  
Author(s):  
Pascal Peu ◽  
Sylvie Picard ◽  
Arnaud Diara ◽  
Romain Girault ◽  
Fabrice Béline ◽  
...  

Molecules ◽  
2017 ◽  
Vol 22 (4) ◽  
pp. 530 ◽  
Author(s):  
Patrycja Bronowicka-Adamska ◽  
Maria Wróbel ◽  
Marcin Magierowski ◽  
Katarzyna Magierowska ◽  
Sławomir Kwiecień ◽  
...  

2005 ◽  
Vol 51 (10) ◽  
pp. 291-300 ◽  
Author(s):  
D.J. Roser ◽  
N. Ashbolt ◽  
G. Ho ◽  
K. Mathew ◽  
J. Nair ◽  
...  

The ‘H2S test’ is being advanced for microbiological water quality testing where conventional coliform based methods are impractical or too expensive. It involves ambient temperature incubation of water samples with nutrient formulated to generate hydrogen sulphide when ‘faecal’ bacteria are present. Recently a WHO review identified several concerns including the limited number of comparative studies, formulation variability, and false positives and negatives. In response we have compared the H2S test's ability to detect and quantify faecal contamination in an aquifer impacted by septic tank leachfields with measurements obtained concurrently using conventional bacterial indicators, coliphages, faecal sterol biomarkers, Cryptosporidium and Giardia. Like these other analytes, H2S testing detected a contamination gradient ranging from high (septic liquid) to moderate (exfiltration zones), to background (e.g. domestic bores), corresponding to indicator removal + dilution by factors >106. Presence/absence tests could not distinguish between heavily and slightly contaminated waters, whereas multi-tube testing (e.g. 10 × 10 mL arrays) did. It was concluded that while the WHO review concerns are justified, the H2S test performance shows promise in sanitary survey work, can be improved by employing an mpn approach and has potential to aid in the protection of source water and identifying contaminated groundwater.


2015 ◽  
Vol 91 (4) ◽  
pp. 1055-1062 ◽  
Author(s):  
Jan Moestedt ◽  
Erik Nordell ◽  
Sara Hallin ◽  
Anna Schnürer

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