Editorial for “Characterizing Fibrosis and Inflammation in a Partial Bile Duct Ligation Mouse Model by Multiparametric Magnetic Resonance Imaging”

Objectives: To determine if standard biopsy still has a role in the detection of prostate cancer or clinically significant prostate cancer in biopsy-naive patients with positive multiparametric magnetic resonance imaging. Materials and methods: We extracted, from our prospective maintained fusion biopsy database, patients from March 2014 to December 2018. The detection rate of prostate cancer and clinically significant prostate cancer and complication rate were analysed in a cohort of patients who underwent fusion biopsy alone (group A) or fusion biopsy plus standard biopsy (group B). The International Society of Urological Pathology grade group determined on prostate biopsy with the grade group determined on final pathology among patients who underwent radical prostatectomy were compared. Results: Prostate cancer was found in 249/389 (64.01%) and 215/337 (63.8%) patients in groups A and B, respectively ( P=0.98), while the clinically significant prostate cancer detection rate was 57.8% and 55.1% ( P=0.52). No significant differences in complications were found. No differences in the upgrading rate between biopsy and final pathology finding after radical prostatectomy were recorded. Conclusions: In biopsy-naive patients, with suspected prostate cancer and positive multiparametric magnetic resonance imaging the addition of standard biopsy to fusion biopsy did not increase significantly the detection rate of prostate cancer or clinically significant prostate cancer. Moreover, the rate of upgrading of the cancer grade group between biopsy and final pathology was not affected by the addition of standard biopsy. Level of evidence: Not applicable for this multicentre audit.

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Cost‐effectiveness of multiparametric magnetic resonance imaging and MRI‐guided biopsy in a population‐based prostate cancer screening setting using a micro‐simulation model

Cancer Medicine ◽

10.1002/cam4.3932 ◽

2021 ◽

Author(s):

Abraham M. Getaneh ◽

Eveline AM Heijnsdijk ◽

Harry J. Koning

Keyword(s):

Magnetic Resonance Imaging ◽

Prostate Cancer ◽

Cost Effectiveness ◽

Magnetic Resonance ◽

Prostate Cancer Screening ◽

Population Based ◽

Resonance Imaging ◽

Multiparametric Magnetic Resonance Imaging ◽

Micro Simulation ◽

Mri Guided

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Multi-modal magnetic resonance imaging in a mouse model of concussion

Scientific Data ◽

10.1038/s41597-021-00985-w ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Xuan Vinh To ◽

Fatima A. Nasrallah

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Data Collection ◽

Mouse Model ◽

Meta Analysis ◽

Data Repository ◽

Resonance Imaging ◽

Loss Of Righting Reflex ◽

Post Impact ◽

Magnetic Resonance Imaging Mri

AbstractThis data collection contains Magnetic Resonance Imaging (MRI) data, including structural, diffusion, stimulus-evoked, and resting-state functional MRI and behavioural assessment results, including acute post-impact Loss-of-Righting Reflex time and acute, subacute, and longer-term Neural Severity Score, and Open Field Behaviour obtained from a mouse model of concussion. Four cohorts with 43 3–4 months old male mice in total were used: Sham (n = 14, n = 6 day 2, n = 3 day 7, n = 5 day 14), concussion day 2 (CON 2; n = 9), concussion day 7 (CON 7; n = 10), concussion day 14 (CON 14; n = 10). The data collection contains the aforementioned MRI data in compressed NIFTI format, data sheets on animal’s backgrounds and behavioural outcomes and is made publicly available from a data repository. The available data are intended to facility cross-study comparisons, meta-analysis, and science reproducibility.

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