Structural identification of trace level enol tautomer impurity by on-line hydrogen/deuterium exchange HR-LC/MS in a LTQ-Orbitrap hybrid mass spectrometer

Guodong Chen; Anatoliy Khusid; Ibrahim Daaro; Patrick Irish; Birendra N. Pramanik

doi:10.1002/jms.1232

Structural identification of trace level enol tautomer impurity by on-line hydrogen/deuterium exchange HR-LC/MS in a LTQ-Orbitrap hybrid mass spectrometer

Journal of Mass Spectrometry ◽

10.1002/jms.1232 ◽

2007 ◽

Vol 42 (7) ◽

pp. 967-970 ◽

Cited By ~ 14

Author(s):

Guodong Chen ◽

Anatoliy Khusid ◽

Ibrahim Daaro ◽

Patrick Irish ◽

Birendra N. Pramanik

Keyword(s):

Mass Spectrometer ◽

Structural Identification ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Trace Level ◽

Hybrid Mass Spectrometer ◽

Hydrogen Deuterium ◽

On Line ◽

Enol Tautomer

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Rapid identification of phase I and II metabolites of artemisinin antimalarials using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange technique

Journal of Mass Spectrometry ◽

10.1002/jms.1943 ◽

2011 ◽

Vol 46 (8) ◽

pp. 725-733 ◽

Cited By ~ 23

Author(s):

Tian Liu ◽

Fuying Du ◽

Yakun Wan ◽

Fanping Zhu ◽

Jie Xing

Keyword(s):

Phase I ◽

Mass Spectrometer ◽

Rapid Identification ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Hybrid Mass Spectrometer ◽

Hydrogen Deuterium ◽

Phase I And Ii ◽

Exchange Technique

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Structural characterization ofin vitrorat liver microsomal metabolites of antihistamine desloratadine using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange HR-LC/MS

Journal of Mass Spectrometry ◽

10.1002/jms.1498 ◽

2009 ◽

Vol 44 (2) ◽

pp. 203-213 ◽

Cited By ~ 30

Author(s):

Guodong Chen ◽

Ibrahim Daaro ◽

Birendra N. Pramanik ◽

John J. Piwinski

Keyword(s):

Mass Spectrometer ◽

Structural Characterization ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Hybrid Mass Spectrometer ◽

Hydrogen Deuterium

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Online Hydrogen/Deuterium Exchange Performed in the Ion Mobility Cell of a Hybrid Mass Spectrometer

Analytical Chemistry ◽

10.1021/ac901736j ◽

2009 ◽

Vol 81 (22) ◽

pp. 9365-9371 ◽

Cited By ~ 14

Author(s):

Kornél Nagy ◽

Karine Redeuil ◽

Serge Rezzi

Keyword(s):

Mass Spectrometer ◽

Ion Mobility ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Hybrid Mass Spectrometer ◽

Hydrogen Deuterium

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A Membrane Cell for On-line Hydrogen/Deuterium Exchange to Study Protein Folding and Protein-Protein Interactions by Mass Spectrometry

Molecular & Cellular Proteomics ◽

10.1074/mcp.m110.006510 ◽

2011 ◽

Vol 10 (9) ◽

pp. M110.006510 ◽

Cited By ~ 8

Author(s):

Juan Astorga-Wells ◽

Michael Landreh ◽

Jan Johansson ◽

Tomas Bergman ◽

Hans Jörnvall

Keyword(s):

Mass Spectrometry ◽

Protein Folding ◽

Protein Interactions ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Protein Protein Interactions ◽

Hydrogen Deuterium ◽

On Line ◽

Membrane Cell

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Hydrogen-deuterium exchange studies utilizing a thermospray mass spectrometer interface

Analytical Chemistry ◽

10.1021/ac00170a021 ◽

1988 ◽

Vol 60 (19) ◽

pp. 2090-2095 ◽

Cited By ~ 31

Author(s):

Marshall M. Siegel

Keyword(s):

Mass Spectrometer ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Hydrogen Deuterium

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Oligonucleotide Gas-Phase Hydrogen/Deuterium Exchange with D2S in the Collision Cell of a Quadrupole-Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

Analytical Chemistry ◽

10.1021/ac0713095 ◽

2007 ◽

Vol 79 (20) ◽

pp. 7893-7898 ◽

Cited By ~ 7

Author(s):

Jingjie Mo ◽

Kristina Håkansson

Keyword(s):

Fourier Transform ◽

Gas Phase ◽

Mass Spectrometer ◽

Cyclotron Resonance ◽

Deuterium Exchange ◽

Collision Cell ◽

Ion Cyclotron Resonance ◽

Hydrogen Deuterium Exchange ◽

Ion Cyclotron ◽

Hydrogen Deuterium

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Gas phase hydrogen/deuterium exchange reactions of peptide ions in a quadrupole ion trap mass spectrometer

Proteins Structure Function and Bioinformatics ◽

10.1002/(sici)1097-0134(199705)28:1<53::aid-prot5>3.0.co;2-k ◽

1997 ◽

Vol 28 (1) ◽

pp. 53-58 ◽

Cited By ~ 35

Author(s):

Igor A. Kaltashov ◽

Vladimir M. Doroshenko ◽

Robert J. Cotter

Keyword(s):

Gas Phase ◽

Mass Spectrometer ◽

Ion Trap ◽

Quadrupole Ion Trap ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Peptide Ions ◽

Exchange Reactions ◽

Ion Trap Mass Spectrometer ◽

Hydrogen Deuterium

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Online Hydrogen-Deuterium Exchange and a Tandem-Quadrupole Time-of-Flight Mass Spectrometer Coupled with Liquid Chromatography for Metabolite Identification in Drug Metabolism

Journal of Chromatographic Science ◽

10.1093/chromsci/41.8.398 ◽

2003 ◽

Vol 41 (8) ◽

pp. 398-404 ◽

Cited By ~ 32

Author(s):

A.- E. F. Nassar

Keyword(s):

Liquid Chromatography ◽

Drug Metabolism ◽

Mass Spectrometer ◽

Time Of Flight ◽

Metabolite Identification ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Flight Mass Spectrometer ◽

Hydrogen Deuterium ◽

Tandem Quadrupole

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D. Q. Liu, C. E. C. A. Hop, M. G. Beconi, A. Mao, S.-H. Lee ?Use of on-line hydrogen/deuterium exchange to facilitate metabolite identification?Rapid Communications in Mass Spectrometry, 15(19), 2001, 1832-1839

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.884 ◽

2003 ◽

Vol 17 (3) ◽

pp. 264-264 ◽

Cited By ~ 1

Keyword(s):

Mass Spectrometry ◽

Metabolite Identification ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Hydrogen Deuterium ◽

On Line

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Structure elucidation of highly polar basic degradants by on-line hydrogen/deuterium exchange hydrophilic interaction chromatography coupled to tandem mass spectrometry

Journal of Chromatography A ◽

10.1016/j.chroma.2010.03.040 ◽

2010 ◽

Vol 1217 (22) ◽

pp. 3598-3611 ◽

Cited By ~ 6

Author(s):

Min Liu ◽

Mike Ronk ◽

Da Ren ◽

Judy Ostovic ◽

Nina Cauchon ◽

...

Keyword(s):

Mass Spectrometry ◽

Tandem Mass Spectrometry ◽

Structure Elucidation ◽

Deuterium Exchange ◽

Hydrophilic Interaction Chromatography ◽

Tandem Mass ◽

Hydrogen Deuterium Exchange ◽

Hydrophilic Interaction ◽

Hydrogen Deuterium ◽

On Line

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