Advanced glycation end products: a highly complex set of biologically relevant compounds detected by mass spectrometry

2001 ◽  
Vol 36 (4) ◽  
pp. 370-378 ◽  
Author(s):  
Annunziata Lapolla ◽  
Domenico Fedele ◽  
Luigi Martano ◽  
Nadia Concetta Arico' ◽  
Massimo Garbeglio ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Biologically Relevant ◽  
Glycation End Products ◽  
End Products

Advanced glycation end products of beta2-microglobulin in uremic patients as determined by high resolution mass spectrometry

2014 ◽  
Vol 91 ◽  
pp. 193-201 ◽  
Author(s):  
Laura Bertoletti ◽  
Luca Regazzoni ◽  
Alessandra Altomare ◽  
Raffaella Colombo ◽  
Mara Colzani ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Advanced Glycation End Products ◽  
High Resolution Mass Spectrometry ◽  
Advanced Glycation ◽  
High Resolution Mass ◽  
Glycation End Products ◽  
End Products ◽  
Uremic Patients ◽  
Resolution Mass

Accurate mass measurements by Fourier transform mass spectrometry in the study of advanced glycation end products/peptides

2003 ◽  
Vol 38 (2) ◽  
pp. 196-205 ◽  
Author(s):  
Ester Marotta ◽  
Annunziata Lapolla ◽  
Domenico Fedele ◽  
Antonella Senesi ◽  
Rachele Reitano ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fourier Transform ◽  
Advanced Glycation End Products ◽  
Fourier Transform Mass Spectrometry ◽  
Accurate Mass ◽  
Advanced Glycation ◽  
Mass Measurements ◽  
Accurate Mass Measurements ◽  
Glycation End Products ◽  
End Products

Analysis of DNA-bound advanced glycation end-products by LC and mass spectrometry

2007 ◽  
Vol 855 (1) ◽  
pp. 51-58 ◽  
Author(s):  
Clemens Bidmon ◽  
Matthias Frischmann ◽  
Monika Pischetsrieder
Keyword(s):  
Mass Spectrometry ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals Enzymatic digestion and mass spectrometry in the study of advanced glycation end products/peptides

2004 ◽  
Vol 15 (4) ◽  
pp. 496-509 ◽  
Author(s):  
Annunziata Lapolla ◽  
Domenico Fedele ◽  
Rachele Reitano ◽  
Nadia Concetta Aricò ◽  
Roberta Seraglia ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Advanced Glycation End Products ◽  
Enzymatic Digestion ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

Rapid and simultaneous analysis of advanced glycation end products on silica hydride column: Comparison of ultraviolet, fluorescence, and mass spectrometry detectors

2020 ◽  
Vol 3 (11-12) ◽  
pp. 540-552
Author(s):  
Rafea Naffa ◽  
Jakob Gaar ◽  
Wenkai Zhang ◽  
Catherine Maidment ◽  
Ihsan Shehadi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Advanced Glycation End Products ◽  
Simultaneous Analysis ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Silica Hydride ◽  
Column Comparison

scholarly journals Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects

2020 ◽  
Vol 2020 ◽  
pp. 1-18 ◽  
Author(s):  
Anna Perrone ◽  
Antonio Giovino ◽  
Jubina Benny ◽  
Federico Martinelli
Keyword(s):  
Mass Spectrometry ◽  
Advanced Glycation End Products ◽  
High Resolution Mass Spectrometry ◽  
Mass Spectrometric ◽  
Spectrometric Analysis ◽  
Advanced Glycation ◽  
Epigenetic Effects ◽  
Structural And Functional Properties ◽  
Glycation End Products ◽  
End Products

The advanced glycation end products (AGEs) are organic molecules formed in any living organisms with a great variety of structural and functional properties. They are considered organic markers of the glycation process. Due to their great heterogeneity, there is no specific test for their operational measurement. In this review, we have updated the most common chromatographic, colorimetric, spectroscopic, mass spectrometric, and serological methods, typically used for the determination of AGEs in biological samples. We have described their signaling and signal transduction mechanisms and cell epigenetic effects. Although mass spectrometric analysis is not widespread in the detection of AGEs at the clinical level, this technique is highly promising for the early diagnosis and therapeutics of diseases caused by AGEs. Protocols are available for high-resolution mass spectrometry of glycated proteins although they are characterized by complex machine management. Simpler procedures are available although much less precise than mass spectrometry. Among them, immunochemical tests are very common since they are able to detect AGEs in a simple and immediate way. In these years, new methodologies have been developed using an in vivo novel and noninvasive spectroscopic methods. These methods are based on the measurement of autofluorescence of AGEs. Another method consists of detecting AGEs in the human skin to detect chronic exposure, without the inconvenience of invasive methods. The aim of this review is to compare the different approaches of measuring AGEs at a clinical perspective due to their strict association with oxidative stress and inflammation.

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