scholarly journals Deuterium depleted water, a new tracer to label pulmonary surfactant lipids in adult rabbits

2022 ◽  
Author(s):  
Manuela Simonato ◽  
Francesca Ricci ◽  
Chiara Catozzi ◽  
Matteo Storti ◽  
Sonia Giambelluca ◽  
...  
Keyword(s):  
Pulmonary Surfactant ◽  
Deuterium Depleted Water

Pulmonary surfactant given prophylactically alleviates an asthma attack in guinea-pigs

1996 ◽  
Vol 26 (3) ◽  
pp. 270-275 ◽  
Author(s):  
M. LIU ◽  
L. WANG ◽  
E. LI ◽  
G. ENHORNING
Keyword(s):  
Guinea Pigs ◽  
Pulmonary Surfactant ◽  
Asthma Attack

Foreign Body Reaction to Exogenous Pulmonary Surfactant in an Infant with Hydrops and Cardiomyopathy

1996 ◽  
Vol 16 (1) ◽  
pp. 83-88
Author(s):  
Robert Bendon ◽  
Jim Greenberg ◽  
Sue Heffelfinger
Keyword(s):  
Foreign Body ◽  
Pulmonary Surfactant ◽  
Foreign Body Reaction

ВЛИЯНИЕ ОБЕДНЕННОГО ДЕЙТЕРИЕМ ПИТЬЕВОГО РАЦИОНА НА ФУНКЦИОНАЛЬНОЕ СОСТОЯНИЕ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ ЖИВОТНЫХ В УСЛОВИИ ГИПОКСИИ

2020 ◽  
Vol 65 (6) ◽  
pp. 1196-1202
Author(s):  
С.В. Козин ◽  
◽  
А.А. Кравцов ◽  
Э.И. Злищева ◽  
Л.В. Шурыгина ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Central Nervous System ◽  
Control Level ◽  
Learning Ability ◽  
Hypoxic Exposure ◽  
Amnestic Effect ◽  
Hypoxia With Hypercapnia ◽  
Antiamnestic Effect ◽  
The Central Nervous System ◽  
Deuterium Depleted Water

The effects of prolonged (42 days) addition of deuterium-depleted water into rat’s diet on the functional state of the central nervous system in normal conditions and under conditions of normobaric hypoxia with hypercapnia were studied. It was also established that the use of deuterium-depleted water both in normal conditions and after exposure to oxidative stress contributes to a significant reduction in the emotional anxiety of animals. Prolonged use of deuterium-depleted water before hypoxic exposure (amnestic effect) helps to maintain learning and memory at the control level, i.e. it has a pronounced protective antiamnestic effect. In normal conditions, deuterium-depleted water does not affect the learning ability of animals.

Screening and Identification of Aptamers Aganinst Pulmonary Surfactant Protein A

2013 ◽  
Vol 41 (11) ◽  
pp. 1659
Author(s):  
Li-Juan LIU ◽  
Yi CHEN ◽  
Wei WANG ◽  
Chao CHEN ◽  
Ming-Hao GAO ◽  
...  
Keyword(s):  
Pulmonary Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Screening And Identification ◽  
Pulmonary Surfactant Protein

Possible benefits of reformulating antiviral drugs with nanoemulsion system in the treatment of novel coronavirus infection

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Manish Kumar ◽  
Chandra Prakash Jain
Keyword(s):  
Drug Delivery ◽  
Drug Therapy ◽  
Pulmonary Surfactant ◽  
Antiviral Drug ◽  
Treatment Strategies ◽  
Drug Dosage ◽  
Antiviral Drugs ◽  
Antiviral Action ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Background: An outbreak of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection or COVID 19, causing serious threats to all around the world. Until an effective and safe vaccine for novel coronavirus is developed by scientists, current drug therapy should by optimize for the control and treatment of COVID 19. Objective: In this manuscript, we are presenting a perspective on possible benefits of reformulating antiviral drug dosage form with nanoemulsion system against novel coronavirus infection. Methods: Literature review has been done on COVID 19, treatment strategies, novel drug delivery systems and role of pulmonary surfactant on lungs protection. Results: Nanoemulsion system and its components have certain biophysical properties which could increase the efficacy of drug therapy. Antiviral drugs, delivered through a nanoemulsion system containing P-gp inhibitor (surfactant and cosolvent), can inhibit the cellular resistance to drugs and would potentiate the antiviral action of drugs. Pulmonary surfactant (PS) assisted antiviral drug delivery by nanoemulsion system could be another effective approach for the treatment of COVID 19. Use of functional excipients like pulmonary surfactant (PS) and surfactant proteins (SPs), in the formulation of the antiviral drug-loaded nanoemulsion system can improve the treatment of coronavirus infection. Conclusion: In our opinion for synergizing antiviral action, lipid and protein portion of PS and their commercial analogs should be explored by pharmaceutical scientists to use them as a functional excipient in the formulation of antiviral drugloaded nanoemulsion system.

scholarly journals Primary structure of rat pulmonary surfactant protein D. cDNA and deduced amino acid sequence.

1992 ◽  
Vol 267 (3) ◽  
pp. 1853-1857 ◽  
Author(s):  
H Shimizu ◽  
J H Fisher ◽  
P Papst ◽  
B Benson ◽  
K Lau ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Primary Structure ◽  
Pulmonary Surfactant ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Pulmonary Surfactant Protein
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