scholarly journals Virological outcomes in patients infected chronically with hepatitis B virus genotype A in comparison with genotypes B and C

2005 ◽  
Vol 78 (1) ◽  
pp. 60-67 ◽  
Author(s):  
Mariko Kobayashi ◽  
Norio Akuta ◽  
Fumitaka Suzuki ◽  
Yoshiyuki Suzuki ◽  
Yasuji Arase ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Genotype ◽  
B Virus ◽  
Virological Outcomes ◽  
Genotype A

Molecular characteristics of hepatitis B virus genotype a confer a higher response rate to interferon treatment

2001 ◽  
Vol 34 ◽  
pp. 15-16 ◽  
Author(s):  
J. Hou ◽  
R. Schilling ◽  
H.L.A. Janssen ◽  
R.A. Heijtink ◽  
R. Williams ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Response Rate ◽  
Molecular Characteristics ◽  
Interferon Treatment ◽  
Virus Genotype ◽  
B Virus ◽  
Genotype A

scholarly journals Novel Hepatitis B Virus Genotype A Subtyping Assay That Distinguishes Subtype Aa from Ae and Its Application in Epidemiological Studies

2004 ◽  
Vol 78 (14) ◽  
pp. 7575-7581 ◽  
Author(s):  
Izumi Hasegawa ◽  
Yasuhito Tanaka ◽  
Anna Kramvis ◽  
Takanobu Kato ◽  
Fuminaka Sugauchi ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Clinical Manifestations ◽  
The United States ◽  
Sub Saharan Africa ◽  
Virus Genotype ◽  
Hbv Genotype ◽  
Specificity And Sensitivity ◽  
B Virus ◽  
Genotype A

ABSTRACT The eight genotypes of hepatitis B virus (HBV) have different geographical distributions, virological characteristics, and clinical manifestations. A unique subtype of HBV genotype A (HBV/A) was reported in sub-Saharan Africa, raising the possibility that patients infected with this subtype (HBV/Aa [“a” for African and Asian]) may have different clinical outcomes than other HBV/A isolates (HBV/Ae [“e” for European]). Comparison between 30 HBV/Aa and 30 HBV/Ae isolates indicated that almost all HBV/Ae isolates had G at nucleotide (nt) 1809 and C at nt 1812, whereas HBV/Aa isolates had T1809/T1812. Taking advantage of these two single nucleotide polymorphisms (SNPs), a novel subtype-specific PCR assay in the X/precore/core region was developed. This assay was combined with a restriction fragment length polymorphism assay using BglII in a different region (nt 1984 to 1989), which has a SNP distinguishing HBV/Aa from HBV/Ae, resulting in 100% specificity for the combined assay. Application of the subtyping assay using sera from 109 paid donors in the United States indicated significantly different distributions of HBV/A subtypes among races; African-Americans, Caucasians, and Hispanics had HBV/Ae, whereas Asians had mainly HBV/Aa, suggesting that the HBV/Aa isolates may have been imported by recent immigration from Asia. In conclusion, the specificity and sensitivity of the combined subtyping assay were confirmed, and its usefulness was demonstrated in a practical context.

scholarly journals Outbreak of Infections by Hepatitis B Virus Genotype A and Transmission of Genetic Drug Resistance in Patients Coinfected with HIV-1 in Japan

2011 ◽  
Vol 49 (3) ◽  
pp. 1017-1024 ◽  
Author(s):  
S. Fujisaki ◽  
Y. Yokomaku ◽  
T. Shiino ◽  
T. Koibuchi ◽  
J. Hattori ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Genotype ◽  
B Virus ◽  
Hiv 1 ◽  
Genotype A

scholarly journals Hepatitis B virus genotype: A missing link in transmission risk and disease progression?

Hepatology ◽  
2008 ◽  
Vol 47 (5) ◽  
pp. 1788-1790
Author(s):  
Stevan A. Gonzalez ◽  
Emmet B. Keeffe
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Disease Progression ◽  
Transmission Risk ◽  
Virus Genotype ◽  
Missing Link ◽  
B Virus ◽  
Genotype A

Molecular characterization of hepatitis B virus genotype A from Argentina and Brazil

2009 ◽  
Vol 154 (3) ◽  
pp. 525-529 ◽  
Author(s):  
Viviana Andrea Mbayed ◽  
Flavia Guadalupe Piñeiro y Leone ◽  
Silvana Claudia Pezzano ◽  
Rodolfo Héctor Campos
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Molecular Characterization ◽  
Virus Genotype ◽  
B Virus ◽  
Genotype A

Temporal and geographic spreading of hepatitis B virus genotype A (HBV‐A) in Brazil and the Americas

2021 ◽  
Author(s):  
Jonas Michel Wolf ◽  
Vagner Reinaldo Zingalli Bueno Pereira ◽  
Daniel Simon ◽  
Vagner Ricardo Lunge
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Genotype ◽  
B Virus ◽  
Genotype A

Does the spread of hepatitis B virus genotype A increase the risk of intrafamilial transmission in Japan?

2011 ◽  
Vol 17 (2) ◽  
pp. 272-277 ◽  
Author(s):  
Haruki Komatsu ◽  
Hidenori Sugawara ◽  
Ayano Inui ◽  
Eitaro Hiejima ◽  
Tsuyoshi Sogo ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Genotype ◽  
Intrafamilial Transmission ◽  
B Virus ◽  
Genotype A

scholarly journals Epidemiological and sequence differences between two subtypes (Ae and Aa) of hepatitis B virus genotype A

2004 ◽  
Vol 85 (4) ◽  
pp. 811-820 ◽  
Author(s):  
Fuminaka Sugauchi ◽  
Hiromitsu Kumada ◽  
Subrat A. Acharya ◽  
Santosh Man Shrestha ◽  
Maria Teresita A. Gamutan ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Sequence Variation ◽  
Core Promoter ◽  
The Philippines ◽  
Virus Genotype ◽  
Double Mutation ◽  
B Virus ◽  
The Usa ◽  
Genotype A

Complete nucleotide sequences of 19 hepatitis B virus (HBV) isolates of genotype A (HBV/A) were determined and analysed along with those of 20 previously reported HBV/A isolates. Of the 19 HBV/A isolates, six including three from Japan and three from the USA clustered with the 14 HBV/A isolates from Western countries. The remaining 13 isolates including four from The Philippines, two from India, three from Nepal and four from Bangladesh clustered with the six HBV/A isolates reported from The Philippines, South Africa and Malawi. Due to distinct epidemiological distributions, genotype A in the 20 HBV isolates was classified into subtype Ae (e for Europe), and that in the other 19 into subtype Aa (a for Asia and Africa) provisionally. The 19 HBV/Aa isolates had a sequence variation significantly greater than that of the 20 HBV/Ae isolates (2·5±0·3 % vs 1·1±0·6 %, P<0·0001); they differed by 5·0±0·4 % (4·1–6·4 %). The double mutation (T1762/A1764) in the core promoter was significantly more frequent in HBV/Aa isolates than in HBV/Ae isolates (11/19 or 58 % vs 5/20 or 25 %, P<0·01). In the pregenome encapsidation (ε) signal, a point mutation from G to A or T at nt 1862 was detected in 16 of the 19 (84 %) HBV/Aa isolates but not in any of the 20 HBV/Ae isolates, which may affect virus replication and translation of hepatitis B e antigen. Subtypes Aa and Ae of genotype A deserve evaluation for any clinical differences between them, with a special reference to hepatocellular carcinoma prevalent in Africa.

Infection with hepatitis B virus genotype A in Tokyo, Japan during 1976 through 2001

2004 ◽  
Vol 39 (9) ◽  
pp. 844-850 ◽  
Author(s):  
Mariko Kobayashi ◽  
Fumitaka Suzuki ◽  
Yasuji Arase ◽  
Norio Akuta ◽  
Yoshiyuki Suzuki ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Genotype ◽  
B Virus ◽  
Genotype A
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