HIV-1 seroconversion promotes rapid changes in cervical human papillomavirus (HPV) prevalence and HPV-16 antibodies in female sex workers

Female sex workers (FSWs) have a notably high risk of acquiring human papillomavirus (HPV) infections. Relatively few studies address the type-specific prevalence and incidence of HPV among FSWs in sub-Saharan Africa. FSWs (n = 348) attending the Korogocho clinic in Nairobi, Kenya participated from August 2009 to March 2011. HPV DNA was detected using the SPF10-LiPA25 PCR assay. Baseline prevalence of HPV infection and cervical dysplasia were calculated, stratified by HIV-serostatus. Incidence rate (IR) of infection was calculated as number of new infections from baseline over person-months among 160 HPV-negative participants with complete 12-month follow-up. Baseline HPV prevalence was 23.6% for any HPV and 20.4% for high-risk HPV (hrHPV) types. Most prevalent types were HPV52 (10.1%), HPV35 (2.3%), and HPV51 (2.3%). A quarter (24%) of participants were HIV-positive. HPV prevalence was higher in HIV-positive (32.1%) than HIV-negative (20.8%) participants. hrHPV prevalence was higher in HIV-positive (27.4%) than HIV-negative (18.2%) women. During follow-up, HPV IR was 31.4 (95% CI: 23.8–41.5) for any HPV and 24.2 (95% CI: 17.9–32.8) for hrHPV types. HPV52 had the highest IR (6.0; 95% CI: 6.5–10.3). Overall HPV and hrHPV prevalence were lower than expected, but both prevalence and incidence were higher in HIV-positive than in HIV-negative women.

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Human papillomavirus infection among male clients of female sex workers soliciting sex in brothels in Peru

International Journal of STD & AIDS ◽

10.1177/0956462417721563 ◽

2017 ◽

Vol 29 (2) ◽

pp. 178-184 ◽

Cited By ~ 1

Author(s):

Jenell Stewart ◽

Martha Calderon ◽

Alison Hathaway ◽

Rachel L Winer ◽

Joseph Zunt

Keyword(s):

Human Papillomavirus ◽

Sex Workers ◽

Female Sex Workers ◽

Transmitted Infection ◽

Hpv Dna ◽

Sexually Transmitted ◽

Female Sex ◽

Male Clients ◽

Hpv Prevalence ◽

The Difference

The prevalence of high-risk human papillomavirus (HR-HPV) has been reported to be three times higher in female sex workers (FSWs) in Callao, Peru than in the general population of women in Peru. Prevalence of HR-HPV among male clients has not yet been reported. A total of 150 men soliciting intercourse in sex work venues submitted questionnaires, samples for sexually transmitted infection (STI) testing, and self-collected penile samples prior to and following intercourse for HPV genotyping. We identified variables associated with pre-coital HR-HPV, and compared HR-HPV detection pre- and post-coitus. Prior to intercourse, HR-HPV prevalence was 41.9%. Married clients were less likely than unmarried clients to have HR-HPV detected ( p = 0.03). While post-coital HR-HPV prevalence was higher (47.6%), the difference was not statistically significant. However, there was a significant increase in the mean number of HR-HPV DNA strains detected before (0.75) and after (0.94) intercourse ( p = 0.02). No cases of gonorrhoea or syphilis and six (4.1%) cases of chlamydial infection were detected. Despite low prevalence of other STIs, male clients had a high HR-HPV prevalence. The increase in detection of HR-HPV following intercourse demonstrates a potential for transmission of HR-HPV despite high self-reported condom use.

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The impact of the use of COL-1492, a nonoxynol-9 vaginal gel, on the presence of cervical human papillomavirus in female sex workers

Virus Research ◽

10.1016/j.virusres.2006.04.009 ◽

2006 ◽

Vol 121 (2) ◽

pp. 220-222 ◽

Cited By ~ 19

Author(s):

Dianne Marais ◽

Henri Carrara ◽

Patti Kay ◽

Gita Ramjee ◽

Bruce Allan ◽

...

Keyword(s):

Human Papillomavirus ◽

Sex Workers ◽

Female Sex Workers ◽

Female Sex ◽

Vaginal Gel ◽

The Impact ◽

Cervical Human Papillomavirus

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Oral sex practices, oral human papillomavirus and correlations between oral and cervical human papillomavirus prevalence among female sex workers in Lima, Peru

International Journal of STD & AIDS ◽

10.1258/ijsa.2011.010541 ◽

2011 ◽

Vol 22 (11) ◽

pp. 655-658 ◽

Cited By ~ 14

Author(s):

B Brown ◽

M M Blas ◽

A Cabral ◽

C Carcamo ◽

P E Gravitt ◽

...

Keyword(s):

Human Papillomavirus ◽

Sex Workers ◽

Female Sex Workers ◽

Oral Sex ◽

Oral Rinse ◽

Female Sex ◽

Hpv Prevalence ◽

Oral Hpv ◽

Few Data ◽

Sex Practices

Few data exist on oral human papillomavirus (HPV) prevalence in female sex workers (FSWs). Information regarding oral sex practices of 185 Peruvian FSWs, 18-26 years of age, was obtained via survey and compared with HPV testing results of oral rinse samples. Oral HPV prevalence was 14/185 (7.6%); four (28.9%) HPV genotypes were carcinogenic. One hundred and eighty-two participants reported having had oral sex; 95% reported condom use during oral sex with clients and 9.5% with partners. Women who had oral sex more than three times with their partners in the past month were more likely to have oral HPV than women who had oral sex three times or less (P = 0.06). Ten (71.4%) women with oral HPV were HPV-positive at the cervix; conversely 8.3% of women with cervical HPV were HPV-positive in the oral cavity. The prevalence of oral HPV was relatively low, considering the high rates of oral sex practiced by these women.

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Prevalence and genotype distribution of cervical human papillomavirus infection among female sex workers in Asia: a systematic literature review and meta-analysis

Sexual Health ◽

10.1071/sh11066 ◽

2012 ◽

Vol 9 (2) ◽

pp. 113 ◽

Cited By ~ 14

Author(s):

Rui-Rui Peng ◽

Hong-Min Li ◽

Helena Chang ◽

Jian-Hong Li ◽

Alberta L. Wang ◽

...

Keyword(s):

Human Papillomavirus ◽

East Asia ◽

Sex Workers ◽

Female Sex Workers ◽

Hpv Infection ◽

South East Asia ◽

Genotype Distribution ◽

Asian Countries ◽

Hpv Prevalence ◽

Cervical Human Papillomavirus

Cervical human papillomavirus (HPV) infection is highly transmissible. Although there are many studies on HPV infection in general population of women globally, little attention has been paid to female sex workers (FSWs) in Asia. In this study, we used a meta-analytic approach to systematically analyse the literature to elucidate the prevalence and genotype distribution of cervical HPV infection among FSWs in Asia. Fourteen eligible studies were identified in five databases, and data including 4198 FSWs from nine Asian countries were aggregated. Crude estimates of cervical HPV prevalence among FSWs in this region ranged from 12.8% to 84.8%. FSWs had a nearly 10-fold risk of HPV infection than the general population of women. Stratified analysis showed that HPV prevalence was higher in East Asia than other subregions and in younger FSWs than older FSWs. HPV genotype distribution was statistically different between East Asia and South-east Asia. In East Asia, the most prevalent genotypes were HPV 16 (23.9%), 18 (11.0%), 58 (9.4%), 56 (6.3%) and 52 (5.3%), while they were HPV 52 (12.9%), 16 (8.5%), 58 (5.2%), 18 (5.0%) and 66 (4.9%) in South-east Asia. HPV 31, 33 and 35 were less frequently found in both subregions. HPV infection was substantial among FSWs in some Asian countries. More studies are necessary to illustrate the overall picture of HPV infection in this region.

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