Genetic diversity of echovirus 30 involved in aseptic meningitis cases in Brazil (1998-2008)

2011 ◽  
Vol 83 (12) ◽  
pp. 2164-2171 ◽  
Author(s):  
Gina Peres Lima dos Santos ◽  
Eliane Veiga da Costa ◽  
Fernando Neto Tavares ◽  
Luciana Jesus da Costa ◽  
Edson Elias da Silva
Keyword(s):  
Genetic Diversity ◽  
Aseptic Meningitis ◽  
Echovirus 30

scholarly journals Temporal phylogeny and molecular characterization of echovirus 30 associated with aseptic meningitis outbreaks in China

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Xiaoling Tian ◽  
Zhenzhi Han ◽  
Yulong He ◽  
Qiang Sun ◽  
Wenrui Wang ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Aseptic Meningitis ◽  
Inner Mongolia ◽  
Etiologic Agent ◽  
Gansu Province ◽  
Isolation And Identification ◽  
Echovirus 30 ◽  
Lineage 2 ◽  
Inner Mongolia Autonomous Region ◽  
Epidemiological Characteristics

Abstract Background An outbreak of aseptic meningitis occurred from June to August 2016, in Inner Mongolia Autonomous Region, China. Methods To determine its epidemiological characteristics, etiologic agent, and possible origin, specimens were collected for virus isolation and identification, followed by molecular epidemiological analysis. Results A total of 363 patients were clinically diagnosed from June 1st to August 31st 2016, and most cases (63.1%, n = 229) were identified between June 22nd and July 17th, with children aged 6 to 12 years constituting the highest percentage (68.9%, n = 250). All viral isolates from this study belonged to genotype C of echovirus 30 (E30), which dominated transmission in China. To date, two E30 transmission lineages have been identified in China, of which Lineage 2 was predominant. We observed fluctuant progress of E30 genetic diversity, with Lineage 2 contributing to increased genetic diversity after 2002, whereas Lineage 1 was significant for the genetic diversity of E30 before 2002. Conclusions We identified the epidemiological and etiological causes of an aseptic meningitis outbreak in Inner Mongolia in 2016, and found that Lineage 2 played an important role in recent outbreaks. Moreover, we found that Gansu province could play an important role in E30 spread and might be a possible origin site. Furthermore, Fujian, Shandong, Taiwan, and Zhejiang provinces also demonstrated significant involvement in E30 evolution and persistence over time in China.

scholarly journals Temporal Phylogeny and Molecular Characterization of Echovirus 30 Associated With Aseptic Meningitis Outbreaks in China

2021 ◽  
Author(s):  
Xiaoling Tian ◽  
Zhenzhi Han ◽  
Yulong He ◽  
Qiang Sun ◽  
Wenrui Wang ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Aseptic Meningitis ◽  
Inner Mongolia ◽  
Etiologic Agent ◽  
Gansu Province ◽  
Isolation And Identification ◽  
Echovirus 30 ◽  
Lineage 2 ◽  
Inner Mongolia Autonomous Region ◽  
Epidemiological Characteristics

Abstract BackgroundAn outbreak of aseptic meningitis occurred from June to August 2016, in Inner Mongolia Autonomous Region, China. MethodsTo determine its epidemiological characteristics, etiologic agent, and possible origin, specimens were collected for virus isolation and identification, followed by molecular epidemiological analysis. ResultsMost cases (63.1%, n = 229) were identified between June 22nd and July 17th, with children aged 6 to 12 years constituting the highest percentage (68.9%, n = 250). All viral isolates from this study belonged to genotype C of echovirus 30 (E-30), which dominated transmission in China. To date, two E-30 transmission lineages have been identified in China, of which Lineage 2 was predominant. We observed fluctuant progress of E-30 genetic diversity, with Lineage 2 contributing to increased genetic diversity after 2002, whereas Lineage 1 was significant for the genetic diversity of E-30 before 2002. ConclusionsWe identified the epidemiological and etiological causes of an aseptic meningitis outbreak in Inner Mongolia in 2016, finding that Lineage 2 played an important role in recent outbreaks. Moreover, we found that Gansu province could play an important role in E-30 spread and might be a possible origin site. Furthermore, Fujian, Shandong, Taiwan, and Zhejiang provinces also demonstrated significant involvement in E-30 evolution and persistence over time in China.

scholarly journals Echovirus 30 associated with cases of aseptic meningitis in state of Pará, Northern Brazil

2009 ◽  
Vol 104 (3) ◽  
pp. 444-450 ◽  
Author(s):  
Ceyla Maria Oeiras de Castro ◽  
Darleise S Oliveira ◽  
Olinda Macedo ◽  
Maria José L Lima ◽  
Marquete B Santana ◽  
...  
Keyword(s):  
Aseptic Meningitis ◽  
Echovirus 30 ◽  
Northern Brazil

scholarly journals Genetic characterization of a novel recombinant echovirus 30 strain causing a regional epidemic of aseptic meningitis in Hokkaido, Japan, 2017

2019 ◽  
Vol 165 (2) ◽  
pp. 433-438
Author(s):  
Masahiro Miyoshi ◽  
Akiko Goto ◽  
Rika Komagome ◽  
Hiroki Yamaguchi ◽  
Yuji Maruo ◽  
...  
Keyword(s):  
Aseptic Meningitis ◽  
Genetic Characterization ◽  
Echovirus 30

scholarly journals Description of a widespread outbreak of aseptic meningitis due to echovirus 30 in Rio de Janeiro state, Brazil

2009 ◽  
Vol 13 (5) ◽  
pp. 367-370 ◽  
Author(s):  
Vitor Laerte Pinto Junior ◽  
Maria Cristina Rebelo ◽  
Eliane Veiga da Costa ◽  
Edson Elias da Silva ◽  
Márcio Neves Bóia
Keyword(s):  
Aseptic Meningitis ◽  
Rio De Janeiro ◽  
Echovirus 30 ◽  
Janeiro State

scholarly journals Identification and Phylogenetic Characterization of Human Enteroviruses Isolated from Cases of Aseptic Meningitis in Brazil, 2013–2017

Viruses ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 690 ◽  
Author(s):  
Emanuelle Ramalho ◽  
Ivanildo Sousa ◽  
Fernanda Burlandy ◽  
Eliane Costa ◽  
Amanda Dias ◽  
...  
Keyword(s):  
Aseptic Meningitis ◽  
Neurological Diseases ◽  
Seasonal Pattern ◽  
Temporal Distribution ◽  
Phylogenetic Characterization ◽  
Echovirus 30 ◽  
Sporadic Cases ◽  
Cell Culture Isolation ◽  
Enterovirus Serotypes

Aseptic meningitis is a common viral infection associated with human enteroviruses. The aim of the present study was to identify and characterize the enteroviruses associated with outbreaks and sporadic cases of aseptic meningitis that occurred in different regions of Brazil between 2013 and 2017. Cerebrospinal fluids obtained from patients admitted to public health facilities were analyzed. A total of 303 patients were positive for Human Enteroviruses (EV) by cell culture isolation with a median isolation rate throughout the year of 12%. We were able to identify enterovirus serotypes in 295 clinical specimens. Nineteen different serotypes were identified; the large majority corresponded to HEV-B species. Echovirus 30 (E-30) and Echovirus 6 (E-6) were the most prevalent genotypes (66.8%). Sequence analysis suggested that circulating E-30 was closely related to E-30 from other American countries; while E-6 was derived from Europe. Most of the patients consisted of children ≤ 15 years old. The temporal distribution of all aseptic meningitis and EV-positive cases showed an obvious seasonal pattern during autumn. Our results have provided valuable information about the enteroviral etiology of the aseptic meningitis cases in Brazil pointing to the importance of enterovirus surveillance in neurological diseases.

scholarly journals Meningitis gone viral: description of the echovirus wave 2013 in Germany

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jonas Graf ◽  
Christian J. Hartmann ◽  
Helmar C. Lehmann ◽  
Carolin Otto ◽  
Ortwin Adams ◽  
...  
Keyword(s):  
Aseptic Meningitis ◽  
University Hospital ◽  
Enteroviral Infection ◽  
Echovirus 30 ◽  
Varicella Zoster ◽  
Fluid Analysis ◽  
Significant Burden ◽  
Simplex Virus ◽  
Herpes Simplex Virus 2 ◽  
The University

Abstract Background Aseptic meningitis epidemics may pose various health care challenges. Methods We describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1st and December 31st, 2013 in order to scrutinize clinical differences from other aseptic meningitis cases. Results A total of 72 enterovirus (EV-positive) meningitis cases were detected in our multicenter cohort, corresponding to 5.8% of all EV-positive cases which were voluntarily reported within the National Enterovirus surveillance (EVSurv, based on investigation of patients with suspected aseptic meningitis/encephalitis and/or acute flaccid paralysis) by physicians within this period of time. Among these 72 patients, 38 (52.8%) were enterovirus positive and typed as echovirus (18 pediatric and 20 adult cases, median age 18.5 years; echovirus 18 (1), echovirus 2 (1), echovirus 30 (31), echovirus 33 (1), echovirus 9 (4)). At the same time, 45 aseptic meningitis cases in our cohort were excluded to be due to enteroviral infection (EV-negative). Three EV-negative patients were tested positive for varicella zoster virus (VZV) and 1 EV-negative patient for herpes simplex virus 2. Hospitalization was significantly longer in EV-negative cases. Cerebrospinal fluid analysis did not reveal significant differences between the two groups. After discharge, EV-meningitis resulted in significant burden of sick leave in our pediatric cohort as parents had to care for the children at home. Conclusions Voluntary syndromic surveillance, such as provided by the EVSurv in our study may be a valuable tool for epidemiological research. Our analyses suggest that EV-positive meningitis predominantly affects younger patients and may be associated with a rather benign clinical course, compared to EV-negative cases.

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