Differential role of tumor necrosis factor receptors in mouse brain inflammatory responses in cryolesion brain injury

2005 ◽  
Vol 82 (5) ◽  
pp. 701-716 ◽  
Author(s):  
Albert Quintana ◽  
Mercedes Giralt ◽  
Santiago Rojas ◽  
Milena Penkowa ◽  
Iain L. Campbell ◽  
...  
Keyword(s):  
Brain Injury ◽  
Tumor Necrosis Factor ◽  
Mouse Brain ◽  
Tumor Necrosis ◽  
Inflammatory Responses ◽  
Tumor Necrosis Factor Receptors ◽  
Necrosis Factor

scholarly journals Genetic Analysis of the Role of Tumor Necrosis Factor Receptors in Functional Outcome after Traumatic Brain Injury in Mice

2010 ◽  
Vol 27 (6) ◽  
pp. 1037-1046 ◽  
Author(s):  
Jinsheng Yang ◽  
Zerong You ◽  
Hyung-Hwan Kim ◽  
Seo-Kyoung Hwang ◽  
Jugta Khuman ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Tumor Necrosis Factor ◽  
Genetic Analysis ◽  
Functional Outcome ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptors ◽  
Necrosis Factor

scholarly journals Opposite Role of Tumor Necrosis Factor Receptors in Dextran Sulfate Sodium-Induced Colitis in Mice

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52924 ◽  
Author(s):  
Ke Wang ◽  
Gencheng Han ◽  
Yan Dou ◽  
Yi Wang ◽  
Guijun Liu ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Tumor Necrosis Factor Receptors ◽  
Necrosis Factor

Role of hypothermia induced by tumor necrosis factor on apoptosis and function of inflammatory neutrophils in mice

2000 ◽  
Vol 278 (1) ◽  
pp. R157-R165 ◽  
Author(s):  
Toshiko Mizuno ◽  
Yukiko Kannan ◽  
Midori Tokunaga ◽  
Mitsuaki Moriyama ◽  
Yasuo Kiso ◽  
...  
Keyword(s):  
Body Temperature ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Inflammatory Responses ◽  
Protein Synthesis Inhibitor ◽  
Neutrophil Accumulation ◽  
Tnf Α ◽  
And Function ◽  
Necrosis Factor

Changes in body temperature and cell infiltration, mediated by cytokines including tumor necrosis factor-α (TNF-α), occur during inflammation, but a role of body temperature on inflammatory responses remains obscure. Intraperitoneal injection of 10% casein to mice resulted in transient hypothermia followed by neutrophil accumulation in peritoneal cavities. Peritoneal TNF-α was rapidly raised, and pretreatment of mice with an anti-TNF-α antibody promoted temperature restoration and partially inhibited neutrophil accumulation. To investigate direct effects of body temperature on neutrophils, peritoneal or peripheral blood neutrophils were cultured at 35°C or 37°C with or without recombinant murine TNF-α (100 ng/ml) or a protein synthesis inhibitor cycloheximide (1 μg/ml). Significant inhibition of spontaneous and TNF-α-induced apoptosis was obtained at 35°C compared with 37°C, an effect that was not altered by the addition of cycloheximide. Moreover, phagocytic ability of peritoneal neutrophils was significantly enhanced by incubating them at the lower temperature. These results indicate that mild hypothermia induced by endogenous TNF-α has enhancing roles on neutrophil survival and function during peritoneal inflammation.

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