Brain Inflammation: Tumor Necrosis Factor Receptors in Mouse Brain Inflammatory Responses

2005 ◽  
Vol 82 (5) ◽  
pp. 701-716 ◽  
Author(s):  
Albert Quintana ◽  
Mercedes Giralt ◽  
Santiago Rojas ◽  
Milena Penkowa ◽  
Iain L. Campbell ◽  
...  

2020 ◽  
Author(s):  
Joao Batista Junior

<div>This study reveals, for the first time, that rosiglitazone and pioglitazone, two thiazolidinedione drugs already approved as therapeutic agents to treat type II diabetes, were found to bind favorably to tumor necrosis factor alpha converting enzyme catalytic site with highlighted binding features.</div><div><br></div>This study suggests that rosiglitazone and pioglitazone, acting as TACE inhibitors agents might avoid or attenuate the hyperexcitability proteolytic activity state of TACE, represent a new potential therapeutic approach to treat SARS-CoV-2 infection-associated severe systemic inflammatory responses observed among severely or critically ill SARS-CoV-2 patients and, consequently, to diminish severe inflammatory‐induced lung injury, ARDS development and death rates.<br><br>


1988 ◽  
Vol 263 (21) ◽  
pp. 10262-10266
Author(s):  
N Watanabe ◽  
H Kuriyama ◽  
H Sone ◽  
H Neda ◽  
N Yamauchi ◽  
...  

1997 ◽  
Vol 43 (3) ◽  
pp. 155-157 ◽  
Author(s):  
Toshiyuki Hata ◽  
Takae Kawamura ◽  
Ritsuto Fujiwaki ◽  
Showa Aoki ◽  
Kohkichi Hata ◽  
...  

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