Involvement of endoplasmic reticulum stress in optic nerve degeneration after chronic high intraocular pressure in DBA/2J mice

2015 ◽  
Vol 93 (11) ◽  
pp. 1675-1683 ◽  
Author(s):  
Kazuki Ojino ◽  
Masamitsu Shimazawa ◽  
Hiroshi Izawa ◽  
Yukimichi Nakano ◽  
Kazuhiro Tsuruma ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Intraocular Pressure ◽  
Optic Nerve ◽  
Endoplasmic Reticulum Stress ◽  
Nerve Degeneration ◽  
Optic Nerve Degeneration

Involvement of endoplasmic reticulum stress in optic nerve degeneration following N-methyl-D-aspartate-induced retinal damage in mice

2012 ◽  
Vol 90 (10) ◽  
pp. 1960-1969 ◽  
Author(s):  
Masamitsu Shimazawa ◽  
Akinori Miwa ◽  
Yasushi Ito ◽  
Kazuhiro Tsuruma ◽  
Makoto Aihara ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Optic Nerve ◽  
Endoplasmic Reticulum Stress ◽  
Nerve Degeneration ◽  
Retinal Damage ◽  
Optic Nerve Degeneration

scholarly journals Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Jeffrey M. Harder ◽  
Pete A. Williams ◽  
Catherine E. Braine ◽  
Hongtian S. Yang ◽  
Jocelyn M. Thomas ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Cell Activity ◽  
Myeloid Cell ◽  
Individual Characteristics ◽  
Nerve Degeneration ◽  
Complement Cascade ◽  
Immune Functions ◽  
Mediators Of Inflammation ◽  
Optic Nerve Degeneration

Abstract Background The risk of glaucoma increases significantly with age and exposure to elevated intraocular pressure, two factors linked with neuroinflammation. The complement cascade is a complex immune process with many bioactive end-products, including mediators of inflammation. Complement cascade activation has been shown in glaucoma patients and models of glaucoma. However, the function of complement-mediated inflammation in glaucoma is largely untested. Here, the complement peptide C3a receptor 1 was genetically disrupted in DBA/2J mice, an ocular hypertensive model of glaucoma, to test its contribution to neurodegeneration. Methods A null allele of C3ar1 was backcrossed into DBA/2J mice. Development of iris disease, ocular hypertension, optic nerve degeneration, retinal ganglion cell activity, loss of RGCs, and myeloid cell infiltration in C3ar1-deficient and sufficient DBA/2J mice were compared across multiple ages. RNA sequencing was performed on microglia from primary culture to determine global effects of C3ar1 on microglia gene expression. Results Deficiency in C3ar1 lowered the risk of degeneration in ocular hypertensive mice without affecting intraocular pressure elevation at 10.5 months of age. Differences were found in the percentage of mice affected, but not in individual characteristics of disease progression. The protective effect of C3ar1 deficiency was then overcome by additional aging and ocular hypertensive injury. Microglia and other myeloid-derived cells were the primary cells identified that express C3ar1. In the absence of C3ar1, microglial expression of genes associated with neuroinflammation and other immune functions were differentially expressed compared to WT. A network analysis of these data suggested that the IL10 signaling pathway is a major interaction partner of C3AR1 signaling in microglia. Conclusions C3AR1 was identified as a damaging neuroinflammatory factor. These data help suggest complement activation causes glaucomatous neurodegeneration through multiple mechanisms, including inflammation. Microglia and infiltrating myeloid cells expressed high levels of C3ar1 and are the primary candidates to mediate its effects. C3AR1 appeared to be a major regulator of microglia reactivity and neuroinflammatory function due to its interaction with IL10 signaling and other immune related pathways. Targeting myeloid-derived cells and C3AR1 signaling with therapies is expected to add to or improve neuroprotective therapeutic strategies.

scholarly journals Retinal and optic nerve degeneration in α-mannosidosis

2018 ◽  
Vol 13 (1) ◽  
Author(s):  
Juliane Matlach ◽  
Thea Zindel ◽  
Yasmina Amraoui ◽  
Laila Arash-Kaps ◽  
Julia B. Hennermann ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Degeneration ◽  
Optic Nerve Degeneration

scholarly journals Neuroglobin effectively halts vision loss in Harlequin mice at an advanced stage of optic nerve degeneration

2021 ◽  
pp. 105483
Author(s):  
Hélène Cwerman-Thibault ◽  
Christophe Lechauve ◽  
Vassilissa Malko-Baverel ◽  
Sébastien Augustin ◽  
Gwendoline Le Guilloux ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Vision Loss ◽  
Nerve Degeneration ◽  
Advanced Stage ◽  
Optic Nerve Degeneration

TNF-α-Induced Optic Nerve Degeneration and Nuclear Factor-κB p65

2006 ◽  
Vol 47 (4) ◽  
pp. 1448 ◽  
Author(s):  
Yasushi Kitaoka ◽  
Yuka Kitaoka ◽  
Jacky M. K. Kwong ◽  
Fred N. Ross-Cisneros ◽  
Jiantao Wang ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nuclear Factor Κb ◽  
Nerve Degeneration ◽  
Nuclear Factor ◽  
Tnf Α ◽  
Optic Nerve Degeneration

Early postnatal Müller cell death leads to retinal but not optic nerve degeneration in NSE-Hu-Bcl-2 transgenic mice

Neuroscience ◽  
1999 ◽  
Vol 95 (1) ◽  
pp. 9-21 ◽  
Author(s):  
M. Dubois-Dauphin ◽  
C. Poitry-Yamate ◽  
F. de Bilbao ◽  
A.K. Julliard ◽  
F. Jourdan ◽  
...  
Keyword(s):  
Cell Death ◽  
Optic Nerve ◽  
Transgenic Mice ◽  
Müller Cell ◽  
Nerve Degeneration ◽  
Muller Cell ◽  
Optic Nerve Degeneration
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