Experimental strategies to promote central nervous system remyelination in multiple sclerosis: Insights gained from the Theiler's virus model system

1995 ◽  
Vol 41 (3) ◽  
pp. 291-296 ◽  
Author(s):  
D. J. Miller ◽  
K. Asakura ◽  
M. Rodriguez
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Model System ◽  
Theiler's Virus ◽  
Virus Model ◽  
Experimental Strategies

Enhancement of central nervous system remyelination in immune and non-immune experimental models of demyelination

1997 ◽  
Vol 3 (2) ◽  
pp. 76-79 ◽  
Author(s):  
Baziel GM van Engelen ◽  
Kevin D Pavelko ◽  
Moses Rodriguez
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Immunoglobulin Therapy ◽  
Experimental Models ◽  
Theiler's Virus ◽  
Experimental Animals ◽  
Myelin Repair ◽  
Immune Mediated ◽  
Virus Model ◽  
Cns Demyelination

Studies in both humans and experimental animals indicate that there is potential for full remyelination following CNS demyelination, but the factors that control the degree of myelin repair are unknown. In the Theiler's virus model of demyelination CNS remyelination can be promoted either by global immunosuppression or by selective immunoglobulin therapy. In this paper we discuss whether immunoglobulin-mediated remyelination is a characteristic of immune-mediated demyelination, or whether immunoglobulin-mediated remyelination also occurs in the toxic-traumatic model of lysolecithin-induced demyelination. Our data support the hypothesis that even in a non-primary immune model of demyelination, manipulating the immune system can be beneficial in myelin repair.

The shiverer mutation affects the persistence of Theiler's virus in the central nervous system.

1997 ◽  
Vol 71 (7) ◽  
pp. 5025-5030 ◽  
Author(s):  
F Bihl ◽  
C Pena-Rossi ◽  
J L Guénet ◽  
M Brahic ◽  
J F Bureau
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Theiler's Virus ◽  
The Central Nervous System
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