scholarly journals Consumption of Lactobacillus reuteri ‐containing lozenges improves periodontal health in navy sailors at sea: A randomized controlled trial

2020 ◽  
Vol 91 (10) ◽  
pp. 1328-1338
Author(s):  
Ulrich Schlagenhauf ◽  
Juliane Rehder ◽  
Götz Gelbrich ◽  
Yvonne Jockel‐Schneider
Keyword(s):  
Randomized Controlled Trial ◽  
Lactobacillus Reuteri ◽  
Controlled Trial ◽  
Periodontal Health ◽  
Randomized Controlled

The effect of orally administered probiotic Lactobacillus reuteri -containing tablets in peri-implant mucositis: a double-blind randomized controlled trial

2015 ◽  
Vol 50 (6) ◽  
pp. 775-785 ◽  
Author(s):  
A. J. Flichy-Fernández ◽  
J. Ata-Ali ◽  
T. Alegre-Domingo ◽  
E. Candel-Martí ◽  
F. Ata-Ali ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Lactobacillus Reuteri ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomized Controlled ◽  
Probiotic Lactobacillus

scholarly journals Bonded versus vacuum-formed retainers: a randomized controlled trial. Part 2: periodontal health outcomes after 12 months

2017 ◽  
Vol 40 (4) ◽  
pp. 399-408 ◽  
Author(s):  
Madeleine Storey ◽  
Katherine Forde ◽  
Simon J Littlewood ◽  
Paul Scott ◽  
Friedy Luther ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Health Outcomes ◽  
Controlled Trial ◽  
Periodontal Health ◽  
Randomized Controlled

scholarly journals Intervention with inulin prior to and during sanative therapy to further support periodontal health: study protocol for a randomized controlled trial

2021 ◽  
Author(s):  
Carly Zanatta ◽  
Peter Fritz ◽  
Elena Comelli ◽  
Wendy Ward
Keyword(s):  
Randomized Controlled Trial ◽  
Gut Microbiota ◽  
Periodontal Disease ◽  
Controlled Trial ◽  
Health Study ◽  
Controlled Study ◽  
Low Grade ◽  
Periodontal Health ◽  
Randomized Controlled ◽  
Markers Of Inflammation

Abstract Background: Periodontal disease is a chronic state of inflammation that can destroy the supporting tissues around the teeth, leading to the resorption of alveolar bone. The initial strategy for treating periodontal disease is non-surgical sanative therapy (ST). Periodontal disease can also induce dysbiosis in the gut microbiota and contribute to low grade systemic inflammation. Prebiotic fibres such as inulin can selectively alter the intestinal microbiota and support homeostasis by improving gut barrier functions and preventing inflammation. Providing an inulin supplement prior to and post-ST may influence periodontal health while providing insight into the complex relationship between periodontal disease and the gut microbiota. The primary objective is to determine if inulin is more effective than the placebo at improving clinical periodontal outcomes including probing depth (PD) and bleeding on probing (BOP). Secondary objectives include determining the effects of inulin supplementation pre and post-ST on salivary markers of inflammation and periodontal-associated pathogens, as these outcomes reflect more rapid changes that can occur.Methods: We will employ a single-center, randomized, double-blind, placebo-controlled study design and recruit and randomize 170 participants who are receiving ST to manage periodontal disease to the intervention (inulin) or placebo (maltodextrin) group. A pilot study will be embedded within the randomized controlled trial using the first 48 participants to test feasibility for the larger, powered trial. The intervention period will begin 4 weeks before ST through to their follow-up appointment at 10 weeks post-ST. Clinical outcomes of periodontal disease including number of sites with PD ≥ 4 mm and the absence of BOP will be measured at baseline and post-ST. Salivary markers of inflammation, periodontal-associated pathogens, body mass index and diet will be measured at baseline, pre-ST (after 4 weeks of intervention) and post-ST (after 14 weeks of intervention). Discussion: We expect that inulin to enhance the positive effect of ST on the management of periodontal disease. The results of the study will provide guidance regarding the use of prebiotics prior to and as a supportive adjunct to ST for periodontal health. Trial registration ClinicalTrials.gov: NCT04670133. Registered on 17 December 2020 https://clinicaltrials.gov/ct2/show/NCT04670133

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