The Random Vibration Effects on Dissolution Testing with USP Apparatus 2

2009 ◽  
Vol 98 (1) ◽  
pp. 297-306 ◽  
Author(s):  
Zongming Gao ◽  
Terry W. Moore ◽  
Lucinda F. Buhse ◽  
William H. Doub
Keyword(s):  
Random Vibration ◽  
Dissolution Testing ◽  
Usp Apparatus ◽  
Usp Apparatus 2

scholarly journals A Comparison of Dissolution Testing on Lipid Soft Gelatin Capsules Using USP Apparatus 2 and Apparatus 4

2005 ◽  
Vol 12 (2) ◽  
pp. 6-9 ◽  
Author(s):  
Jack Hu ◽  
Ali Kyad ◽  
Vivian Ku ◽  
Peter Zhou ◽  
Nina Cauchon
Keyword(s):  
Dissolution Testing ◽  
Gelatin Capsules ◽  
Soft Gelatin Capsules ◽  
Usp Apparatus ◽  
Usp Apparatus 2

scholarly journals Comparison of Dissolution Profiles for Sustained Release Resinates of BCS Class I Drugs Using USP Apparatus 2 and 4: A Technical Note

2008 ◽  
Vol 9 (3) ◽  
pp. 769-773 ◽  
Author(s):  
Namita B. Prabhu ◽  
Ajit S. Marathe ◽  
SatishKumar Jain ◽  
Pirthi Pal Singh ◽  
Kiran Sawant ◽  
...  
Keyword(s):  
Sustained Release ◽  
Technical Note ◽  
Class I ◽  
Usp Apparatus ◽  
Usp Apparatus 2

scholarly journals Comparison of Generic Furosemide Products by In Vitro Release Studies using USP Apparatus 2 and 4

2021 ◽  
Vol 28 (1) ◽  
pp. 14-22
Author(s):  
José Raúl Medina-López ◽  
Alexander Domínguez-Reyes ◽  
Marcela Hurtado
Keyword(s):  
In Vitro Release ◽  
Release Studies ◽  
Usp Apparatus ◽  
Usp Apparatus 2 ◽  
Vitro Release

scholarly journals Development and Study of Semi-Solid Preparations Containing the Model Substance Corticotropin (ACTH): Convenience Application in Neurodegenerative Diseases

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1824
Author(s):  
Wioletta Siemiradzka ◽  
Barbara Dolińska ◽  
Florian Ryszka
Keyword(s):  
Lupus Erythematosus ◽  
Chemical Parameters ◽  
High Concentration ◽  
In Vitro Drug Release ◽  
Model Substance ◽  
Semi Solid ◽  
Usp Apparatus ◽  
Physical And Chemical ◽  
Usp Apparatus 2

Corticotropin (ACTH, previously an adrenocorticotropic hormone) is used in the diagnosis and treatment of pituitary gland disorders, adrenal cortex disorders, and other diseases, including autoimmune polymyositis, systemic lupus erythematosus, rheumatoid arthritis, Crohn’s disease, and ulcerative colitis. So far, the ointment dosage form containing ACTH for use on the skin is unknown. Therefore, it seems appropriate to develop a semi-solid formulation with corticotropin. Emulsion ointments were prepared using an Unguator based on the cream base Lekobaza® containing corticotropin in different concentrations, and then the physical and chemical parameters of the ointment formulations, such as pH, spreadability, rheological properties, and texture analysis, were evaluated. In addition, a USP apparatus 2 with enhancer cells was utilized to study the in vitro drug release characteristics of the selected formulations. All the ointments obtained were characterized by good spreadability and viscosity. An analysis of the ointment texture was performed and the dependence of the tested parameters on the ACTH content in the ointment was demonstrated. Examination of the structure of the ointment showed that a high concentration of ACTH increases the hardness and adhesiveness of the ointment. In turn, it adversely affects the cohesiveness and elasticity of the ointments tested. The results of the release study showed that ACTH is released the fastest from the formulation with the lowest concentration, while the slowest from the ointment with the highest concentration of ACTH.

scholarly journals Altered Dynamics for USP Apparatus 2

1996 ◽  
Vol 3 (3) ◽  
pp. 8-13 ◽  
Author(s):  
Paul G. King
Keyword(s):  
Usp Apparatus ◽  
Usp Apparatus 2

scholarly journals Formulation and In vitro Evaluation of Oral Floating Tablets of Salbutamol Sulphate: Comparison with Effervescent Tablets

2017 ◽  
Vol 15 (2) ◽  
pp. 203-208
Author(s):  
Md Haider Ali ◽  
Mohiuddin Ahmed Bhuiyan ◽  
Md Selim Reza ◽  
Samira Karim
Keyword(s):  
Drug Release ◽  
Oral Delivery ◽  
Dosage Form ◽  
In Vitro Dissolution ◽  
Salbutamol Sulphate ◽  
Floating Tablets ◽  
Gastric Residence Time ◽  
Usp Apparatus ◽  
Usp Apparatus 2

The aim of this research was to develop and evaluate gastric floating tablets of salbutamol sulphate. The oral delivery of anti-asthmatic salbutamol sulphate tablets were facilitated by preparing floating dosage form which could increase its absorption in the stomach by increasing the gastric residence time of the drug. Floating tablets were formulated by using different polymers like carbopol, xanthan gum, HPMC-K4 MCR and HPMC- K100 MCR with different proportions. A comparative study of normal effervescent tablets of salbutamol sulphate had also been done. The prepared tablets were evaluated for all their physicochemical properties and in vitro buoyancy study. In vitro dissolution studies of the formulations were done in pH 6.8 phosphate buffer using USP apparatus 2 (paddle method) at 50 rpm. Percent drug release of the formulations (F-1 to F-11) was from 87.34%- 99.12% after 12 hours. From the results, F-11 was selected as an optimized formulation based on 12 h drug release which showed minimal floating lag time and maximum floating time. On the other hand, 100% drug was released within 2 hours from the F-12 of effervescent salbutamol sulphate tablets in which polymer was absent while gas generating sodium bicarbonate and citric acid were present. The results of the study were consistent and may encourage formulating similar dosage form with other drugs.Dhaka Univ. J. Pharm. Sci. 15(2): 203-208, 2016 (December)

scholarly journals Development of dissolution tests for the quality control of complementary/alternate and traditional medicines: Application to African potato products

2008 ◽  
Vol 11 (3) ◽  
pp. 35 ◽  
Author(s):  
Vipin Devi Prasad Nair ◽  
Isadore Kanfer
Keyword(s):  
Quality Control ◽  
Water Solubility ◽  
Water Soluble ◽  
Dissolution Testing ◽  
Fed State ◽  
Traditional Medicines ◽  
Testing Procedures ◽  
Marker Compound ◽  
Biorelevant Dissolution ◽  
Usp Apparatus

ABSTRACT - Purpose: Unlike orthodox medicines, specific guidelines for dissolution testing of complementary/alternate (CAMs) and traditional medicines (TMs) have not been developed nor is dissolution testing a requirement for the quality control of such products. In this report, the dissolution of African Potato (AP) products, an African traditional medicine (ATM) which has been ingested by man for a diversity of ailments, has been investigated. A norlignan glycoside namely hypoxoside and a sterol, ?-sitosterol (BSS) are purported to be the most important phytochemicals in marketed products of AP. Dissolution testing of AP products containing labelled content of sterols and those containing only hypoxoside is proposed whereby BSS and hypoxoside are monitored as markers for the release of the contents of the abovementioned products, respectively. Methods: The FDA dissolution guidance for industry was used to study the best dissolution condition for several formulations of AP. Buffers in the range of pH 1.2 to 7.5 were used to investigate the dissolution of AP products containing hypoxoside as a marker compound. Similarly, biorelevant dissolution media such as fasted state simulation fluid (FaSSIF) and fed state simulation fluid (FeSSIF) at different pH were used to investigate the release of BSS in AP formulations labelled to contain sterols which exhibited poor water solubility. Results: Dissolution testing of AP products containing hypoxoside, conducted at pH 1.2 using USP Apparatus 1 indicated that more than 75% of hypoxoside was released within 1 hr. Dissolution testing of products containing sterols, conducted in FeSSIF at a pH of 5.0 resulted in a release of at least 75% of BSS after 1 hr for all but one of the products tested. Conclusions: Dissolution testing conditions have been developed for AP products containing two different marker compounds where one of the components, hypoxoside, is water soluble, whereas another component, BSS is poorly water soluble. This necessitated the use of different dissolution media and pHs in order to monitor the respective release of hypoxoside and BSS from AP products. The results of this study indicate the necessity and possibility of developing appropriate dissolution testing procedures for use in the quality control of CAMs/TMs.

scholarly journals Release Modification of Indomethacin Controlled Release Press Coated Tablets

2016 ◽  
Vol 19 (2) ◽  
pp. 219-225 ◽  
Author(s):  
Muhammad Rashedul Islam ◽  
Md Elias Al Mamun ◽  
Md Mizanur Rahman Moghal
Keyword(s):  
Drug Release ◽  
Pharmaceutical Journal ◽  
In Vitro Dissolution ◽  
Compression Pressure ◽  
Pressure Formulation ◽  
Release Data ◽  
Usp Apparatus ◽  
Usp Apparatus 2 ◽  
Core Tablet

The study was carried out to evaluate the release modification of indomethacin press coated tablets through different polymers. Several batches of press coated tablets were prepared with indomethacin and Avicel PH 102. The core tablet was compression coated with minimal compression pressure. Formulation IX was modified by incorporating PEG 6000, sodium chloride and sodium lauryl sulphate (SLS). In vitro dissolution studies of the formulations of different excipients were done at pH 7.2 in phosphate buffer using USP apparatus 2 (paddle method) at 50 rpm and 37 ± 0.5 °C temperature. The drug release data was treated in different mathematical fashion to identify the kinetic behaviour. It was found that, drug release which was inversely proportional to the amount of xanthan gum in the coating formulations was significantly changed by the polymers used in the study. Incorporation of SLS caused the drug to be released in near zero order fashion. Drug release was found to follow Higuchi mechanism for all the formulations. The study reveals that the polymers used may be a significant factor for the discrepancy in release rate of indomethacin.Bangladesh Pharmaceutical Journal 19(2): 219-225, 2016

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