scholarly journals Development and Study of Semi-Solid Preparations Containing the Model Substance Corticotropin (ACTH): Convenience Application in Neurodegenerative Diseases

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1824
Author(s):  
Wioletta Siemiradzka ◽  
Barbara Dolińska ◽  
Florian Ryszka
Keyword(s):  
Lupus Erythematosus ◽  
Chemical Parameters ◽  
High Concentration ◽  
In Vitro Drug Release ◽  
Model Substance ◽  
Semi Solid ◽  
Usp Apparatus ◽  
Physical And Chemical ◽  
Usp Apparatus 2

Corticotropin (ACTH, previously an adrenocorticotropic hormone) is used in the diagnosis and treatment of pituitary gland disorders, adrenal cortex disorders, and other diseases, including autoimmune polymyositis, systemic lupus erythematosus, rheumatoid arthritis, Crohn’s disease, and ulcerative colitis. So far, the ointment dosage form containing ACTH for use on the skin is unknown. Therefore, it seems appropriate to develop a semi-solid formulation with corticotropin. Emulsion ointments were prepared using an Unguator based on the cream base Lekobaza® containing corticotropin in different concentrations, and then the physical and chemical parameters of the ointment formulations, such as pH, spreadability, rheological properties, and texture analysis, were evaluated. In addition, a USP apparatus 2 with enhancer cells was utilized to study the in vitro drug release characteristics of the selected formulations. All the ointments obtained were characterized by good spreadability and viscosity. An analysis of the ointment texture was performed and the dependence of the tested parameters on the ACTH content in the ointment was demonstrated. Examination of the structure of the ointment showed that a high concentration of ACTH increases the hardness and adhesiveness of the ointment. In turn, it adversely affects the cohesiveness and elasticity of the ointments tested. The results of the release study showed that ACTH is released the fastest from the formulation with the lowest concentration, while the slowest from the ointment with the highest concentration of ACTH.

scholarly journals Isolation and Identification of Heavy Metal Tolerant Bacteria from Tannery Effluents

2016 ◽  
Vol 29 (1) ◽  
pp. 23-26
Author(s):  
M Iqbal Hossain ◽  
M Nural Anwar
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Bacillus Coagulans ◽  
Bacillus Firmus ◽  
Chemical Parameters ◽  
High Concentration ◽  
Isolation And Identification ◽  
Tannery Effluents ◽  
Physical And Chemical ◽  
Metal Tolerant Bacteria

The aim and objective of the study was to isolate and characterize heavy metal tolerant microorganisms from tannery effluents. Six effluent samples were collected aseptically and their physical and chemical parameters were determined. A total of 40 bacterial colonies were isolated from these effluent samples. Among them, six bacterial isolates were characterized provisionally as Alcaligenes aquamarinus, Bacillus coagulans, Bacillus firmus, Enterobacter cloacae, Pseudomonas alcaligens and Pseudomonas mendocina based on morphological, cultural and biochemical characteristics. The survibality and tolerance to heavy metals (Cr and Cu) of these isolates were examined. All the isolates were found to grow at high concentration of CuSO4 (95ppm/ml) and varying degrees of chromium (K2Cr2O7). The highest tolerance was shown by Alcaligenes aquamarinus. These heavy metal tolerant organisms could be potential agents for bioremediation of heavy metals polluted environment.Bangladesh J Microbiol, Volume 29, Number 1, June 2012, pp 23-26

scholarly journals Comparison of Generic Furosemide Products by In Vitro Release Studies using USP Apparatus 2 and 4

2021 ◽  
Vol 28 (1) ◽  
pp. 14-22
Author(s):  
José Raúl Medina-López ◽  
Alexander Domínguez-Reyes ◽  
Marcela Hurtado
Keyword(s):  
In Vitro Release ◽  
Release Studies ◽  
Usp Apparatus ◽  
Usp Apparatus 2 ◽  
Vitro Release

FORMULATION AND EVALUATION OF RUTIN TRIHYDRATE EMULGEL

INDIAN DRUGS ◽  
2021 ◽  
Vol 57 (11) ◽  
pp. 87-92
Author(s):  
C Sushmitha ◽  
◽  
M.P. Kusuma ◽  
J Archana
Keyword(s):  
Drug Release ◽  
Water Solubility ◽  
Guar Gum ◽  
Ex Vivo ◽  
Normal Skin ◽  
Inflammatory Activity ◽  
In Vitro Drug Release ◽  
Anti Inflammatory ◽  
Semi Solid

Emulgels (emulsion gels) are a class of biphasic semi-solid formulations, having aqueous and non-aqueous phases, delivering both hydrophilic and lipophilic agents. The main advantage of an emulgel is that lipophilic drugs can be easily formulated as emulgels. Rutin trihydrate is an herbal drug used for topical treatment of inflammation. However, its poor water solubility (0.125 mg/ml) presents a hindrance for its local bioavailability and limits effective anti-inflammatory activity. The aim of the current study was to formulate and optimize rutin trihydrate emulgel to enhance its efficacy and stability. 28 formulations were developed with various types of gelling agents like Carbapol 934 (0.8 and 1% w/v), Xanthum gum (1.5 and 2% w/v), HPMCk15 (2, 2.5 and 3% w/v),HPMC K100 (2, 2.5% w/v), guar gum (1, 1.5 and 2% w/v), badam gum (1% w/v) and using various permeation enhancers like clove oil, eucalyptus oil and oil of orange (10 and12.5% v/v). The optimised formulation (f8) was yellow in colour, homogeneous with good consistency, possessed pH of 6.51±0.04 that is very close to that of normal skin (6-7), drug content of 98.7%, viscosity of 14,680cps at 30rpm, spreadability 13.5gm.cm/sec and extrudability 36.2% and in vitro drug release of 79.3% for 7 hrs, ex vivo drug release of 70.08% was stable for 3 months and was having comparable anti inflammatory activity with that of marketed formulation.

scholarly journals DEVELOPMENT OF MUCOADHESIVE TABLET OF PENTOXIFYLLINE USING A NATURAL POLYMER FROM MANILKARA ZAPOTA LINN

2019 ◽  
pp. 88-91
Author(s):  
GNANASEKARAN JOHN SELVARAJ ◽  
ARUL BALASUBRAMANIAN ◽  
KOTHAI RAMALINGAM
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Natural Polymer ◽  
High Concentration ◽  
In Vitro Drug Release ◽  
Manilkara Zapota ◽  
Mucoadhesive Polymer ◽  
Weight Variation ◽  
Release Studies

Objective: The present study was designed to develop a mucoadhesive tablet of pentoxifylline using the mucoadhesive natural polymer from the plant Manilkara zapota Linn. Methods: The tablets were formulated with three different concentrations of the isolated polymer and evaluated for thickness, weight variation, friability, hardness, swelling index, mucoadhesive strength and in vitro drug release. The swelling index was indirectly proportional to the mucoadhesive polymer of Manilkara zapota (MAPMZ) concentration. Results: The tablets formulated with a high concentration of MAPMZ showed good mucoadhesion strength in 5 min contact time. The in vitro drug release studies indicated that the drug release was directly proportional to MAPMZ concentration. The release kinetics indicated that the drug release was followed the zero-order. Conclusion: The MAPMZ showed the controlled release of pentoxifylline for a period of 12 h.

In vitro evaluation of physical and chemical parameters involved in aPDT of Aggregatibacter actinomycetemcomitans

2021 ◽  
Author(s):  
Gerdal Roberto de Sousa ◽  
Leandro O. Soares ◽  
Betânia M. Soares ◽  
Rosana de Carvalho Cruz ◽  
Paulo Uliana Junior ◽  
...  
Keyword(s):  
Aggregatibacter Actinomycetemcomitans ◽  
Chemical Parameters ◽  
In Vitro Evaluation ◽  
Physical And Chemical Parameters ◽  
Physical And Chemical

scholarly journals Stomatologic materials biotesting in vitro

2013 ◽  
Vol 94 (5) ◽  
pp. 667-672
Author(s):  
E M Gilmiyarov ◽  
K I Kolesova ◽  
B M Radomskaya ◽  
A V Babichev
Keyword(s):  
Redox Potential ◽  
Oral Fluid ◽  
Adhesive System ◽  
Single Bond ◽  
Chemical Parameters ◽  
Universal Adhesive ◽  
Physical And Chemical Parameters ◽  
Oral Liquid ◽  
Physical And Chemical

Aim. To clarify the specific influence of an adhesive system («Single Bond Universal») on contents, physical and chemical parameters of oral liquid to confirm its safety for use in common dental practice. Methods. A series of in vitro experiments of 5 and 20 seconds of 3 ml oral liquid photopolymerization of 23 dentally and generally healthy subjects aged 18-25 years were performed. Salivary acidity (pH), redox potential, structure, absorption specters, membrane toxicity parameters were assessed. Results. An adhesive system shifted the pH to 6.02±0.21, changed the balance of oxidized and reduced substances with redox potential shift without influencing on salivary structuring. «Filtek Ultimate» and «Filtek Bulk Fill» nanocomposites did not altered the acid-base balance, pH was stable and within the control ranges, redox potential was significantly reduced, mainly by «Filtek Ultimate» (3.6 times lower compared to control parameters), it has also increased the oral liquid structuring by 22,7%. Adhesive and nanocomposites had different effect on the contents of nucleated cells materials (nucleotides, nucleosides, purine catabolites) in oral fluid, decreasing the contents of thymine, cytosine nucleotides and their derivatives, confirmed by absorption characteristics of oral fluid after the incubation. It was found that «Single Bond Universal» adhesive system, «Filtek Ultimate» and «Filtek Bulk Fill» nanocomposites also change the physical and chemical parameters of oral liquid and have a membrane-toxic effect on red blood cells. Conclusion. Biotesting of specified stomatologic materials showed that they are not completely bioinert.

scholarly journals Application of USP Apparatus 7 to In Vitro Drug Release in Scopolamine Transdermal Systems

2007 ◽  
Vol 14 (2) ◽  
pp. 25-29 ◽  
Author(s):  
Marilyn X. Zhou ◽  
Duane Shoudt ◽  
Genaro Calderon ◽  
Min Feng
Keyword(s):  
Drug Release ◽  
In Vitro Drug Release ◽  
Usp Apparatus

scholarly journals Formulation and In vitro Evaluation of Oral Floating Tablets of Salbutamol Sulphate: Comparison with Effervescent Tablets

2017 ◽  
Vol 15 (2) ◽  
pp. 203-208
Author(s):  
Md Haider Ali ◽  
Mohiuddin Ahmed Bhuiyan ◽  
Md Selim Reza ◽  
Samira Karim
Keyword(s):  
Drug Release ◽  
Oral Delivery ◽  
Dosage Form ◽  
In Vitro Dissolution ◽  
Salbutamol Sulphate ◽  
Floating Tablets ◽  
Gastric Residence Time ◽  
Usp Apparatus ◽  
Usp Apparatus 2

The aim of this research was to develop and evaluate gastric floating tablets of salbutamol sulphate. The oral delivery of anti-asthmatic salbutamol sulphate tablets were facilitated by preparing floating dosage form which could increase its absorption in the stomach by increasing the gastric residence time of the drug. Floating tablets were formulated by using different polymers like carbopol, xanthan gum, HPMC-K4 MCR and HPMC- K100 MCR with different proportions. A comparative study of normal effervescent tablets of salbutamol sulphate had also been done. The prepared tablets were evaluated for all their physicochemical properties and in vitro buoyancy study. In vitro dissolution studies of the formulations were done in pH 6.8 phosphate buffer using USP apparatus 2 (paddle method) at 50 rpm. Percent drug release of the formulations (F-1 to F-11) was from 87.34%- 99.12% after 12 hours. From the results, F-11 was selected as an optimized formulation based on 12 h drug release which showed minimal floating lag time and maximum floating time. On the other hand, 100% drug was released within 2 hours from the F-12 of effervescent salbutamol sulphate tablets in which polymer was absent while gas generating sodium bicarbonate and citric acid were present. The results of the study were consistent and may encourage formulating similar dosage form with other drugs.Dhaka Univ. J. Pharm. Sci. 15(2): 203-208, 2016 (December)

scholarly journals Release Modification of Indomethacin Controlled Release Press Coated Tablets

2016 ◽  
Vol 19 (2) ◽  
pp. 219-225 ◽  
Author(s):  
Muhammad Rashedul Islam ◽  
Md Elias Al Mamun ◽  
Md Mizanur Rahman Moghal
Keyword(s):  
Drug Release ◽  
Pharmaceutical Journal ◽  
In Vitro Dissolution ◽  
Compression Pressure ◽  
Pressure Formulation ◽  
Release Data ◽  
Usp Apparatus ◽  
Usp Apparatus 2 ◽  
Core Tablet

The study was carried out to evaluate the release modification of indomethacin press coated tablets through different polymers. Several batches of press coated tablets were prepared with indomethacin and Avicel PH 102. The core tablet was compression coated with minimal compression pressure. Formulation IX was modified by incorporating PEG 6000, sodium chloride and sodium lauryl sulphate (SLS). In vitro dissolution studies of the formulations of different excipients were done at pH 7.2 in phosphate buffer using USP apparatus 2 (paddle method) at 50 rpm and 37 ± 0.5 °C temperature. The drug release data was treated in different mathematical fashion to identify the kinetic behaviour. It was found that, drug release which was inversely proportional to the amount of xanthan gum in the coating formulations was significantly changed by the polymers used in the study. Incorporation of SLS caused the drug to be released in near zero order fashion. Drug release was found to follow Higuchi mechanism for all the formulations. The study reveals that the polymers used may be a significant factor for the discrepancy in release rate of indomethacin.Bangladesh Pharmaceutical Journal 19(2): 219-225, 2016

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