scholarly journals Effect of the Subcutaneous Environment on Phase-Sensitive In Situ-Forming Implant Drug Release, Degradation, and Microstructure

2015 ◽  
Vol 104 (12) ◽  
pp. 4322-4328 ◽  
Author(s):  
Luis Solorio ◽  
Agata A. Exner
Keyword(s):  
Drug Release ◽  
In Situ Forming ◽  
Phase Sensitive

In Vitro and In Vivo Drug Release from a Novel In Situ Forming Drug Delivery System

2007 ◽  
Vol 25 (6) ◽  
pp. 1347-1354 ◽  
Author(s):  
Heiko Kranz ◽  
Erol Yilmaz ◽  
Gayle A. Brazeau ◽  
Roland Bodmeier
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Situ Forming

scholarly journals In-situ forming PLGA implants: How additives affect swelling and drug release

2019 ◽  
Vol 53 ◽  
pp. 101180 ◽  
Author(s):  
C. Bode ◽  
H. Kranz ◽  
A. Kruszka ◽  
F. Siepmann ◽  
J. Siepmann
Keyword(s):  
Drug Release ◽  
In Situ Forming

Benzoyl Peroxide In Situ Forming Antimicrobial Gel for Periodontitis Treatment

2013 ◽  
Vol 545 ◽  
pp. 63-68 ◽  
Author(s):  
Jongjan Mahadlek ◽  
Juree Charoenteeraboon ◽  
Thawatchai Phaechamud
Keyword(s):  
Drug Delivery ◽  
Antimicrobial Activity ◽  
Drug Release ◽  
Delivery System ◽  
Periodontal Pocket ◽  
Peppermint Oil ◽  
In Situ Gel ◽  
In Situ Forming ◽  
In Situ Forming Gel

Periodontitis is an inflammatory disease of the supporting structures of the tooth caused by bacterial infection which can result in tooth loss. The local intra-pocket drug delivery system was interesting and highly effective for periodontitis treatment. In situ forming gel system is the polymeric solution which could transform into gel for localizing and sustaining the drug release at desired site. This system has been recommended as one of suitable delivery system for this purpose. Benzoyl peroxide (BPO) in situ forming gels were developed using Eudragit RS as polymer dispersed in N-methyl-pyrrolidone (NMP). Peppermint oil and polyethylene glycol 1500 were also incorporated as the excipients. The prepared systems were evaluated for rheology, syringeability (using texture analyzers), in situ gel formation (after injection into PBS pH 6.8), antimicrobial activity (against Streptococcus mutans with agar diffusion) and drug release (with dialysis method in PBS pH 6.8 at 50 rpm, 37 °C). The viscosity and syringeability of the prepared systems was increased as the amount of BPO, peppermint oil or PEG 1500 was increased. All prepared gels showed the Newtonian flow which the viscosity was decreased as the temperature was increased. All prepared gels comprising peppermint oil and PEG 1500 could form in situ gel in used medium which the pH was close to the environment pH of periodontal pocket. The inhibition zone against Streptococcus mutans of the prepared system was significantly decreased when the peppermint oil and PEG 1500 was incorporated owing to the higher viscous environment and thereafter retardation of drug diffusion was evident. This effect could prolong the drug release. From drug release test, all prepared gels could sustain the BPO release for at least 96 hrs. Release kinetic obtained from curve fitting with various release equations using least square fit technique indicated that the release patterns were as Higuchi’s model therefore the release of BPO was performed with diffusion control. This developed BPO in situ forming gel presented its ability as the controlled drug delivery system for localized antimicrobial activity at periodontal pocket.

scholarly journals Erratum: Investigation of drug release and 1 H-NMR analysis of the in situ forming systems based on poly(lactide-co-glycolide)

2009 ◽  
Vol 20 (5) ◽  
pp. 507-507
Author(s):  
Z. Mohamadnia ◽  
E. Ahmadi ◽  
M. Rafienia ◽  
H. Mirzadeh ◽  
H. Mobedi
Keyword(s):  
Drug Release ◽  
Nmr Analysis ◽  
H Nmr ◽  
In Situ Forming

scholarly journals The Effect of Additives on the Behavior of Phase Sensitive In Situ Forming Implants

2015 ◽  
Vol 104 (10) ◽  
pp. 3471-3480 ◽  
Author(s):  
Luis solorio ◽  
Divya Sundarapandiyan ◽  
Alex Olear ◽  
Agata A. Exner
Keyword(s):  
In Situ Forming ◽  
Effect Of Additives ◽  
Phase Sensitive ◽  
In Situ Forming Implants

scholarly journals Effect of Polymer Permeability and Solvent Removal Rate on In Situ Forming Implants: Drug Burst Release and Microstructure

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 520 ◽  
Author(s):  
Xiaowei Zhang ◽  
Liqun Yang ◽  
Chong Zhang ◽  
Danhua Liu ◽  
Shu Meng ◽  
...  
Keyword(s):  
Drug Release ◽  
Organic Solvent ◽  
Removal Rate ◽  
Solubility Parameters ◽  
Burst Release ◽  
Trimethylene Carbonate ◽  
Solvent Removal ◽  
In Situ Forming ◽  
In Situ Forming Implants

To explore the mechanism of drug release and depot formation of in situ forming implants (ISFIs), osthole-loaded ISFIs were prepared by dissolving polylactide, poly(lactide-co-glycolide), polycaprolactone, or poly(trimethylene carbonate) in different organic solvents, including N-methyl-2-pyrrolidone (NMP), dimethyl sulfoxide (DMSO), and triacetin (TA). Drug release, polymer degradation, solvent removal rate and depot microstructure were examined. The burst release effect could be reduced by using solvents exhibit slow forming phase inversion and less permeable polymers. Both the drug burst release and polymer depot microstructure were closely related to the removal rate of organic solvent. Polymers with higher permeability often displayed faster drug and solvent diffusion rates. Due to high polymer-solvent affinity, some of the organic solvent remained in the depot even after the implant was completely formed. The residual of organic solvent could be predicted by solubility parameters. The ISFI showed a lower initial release in vivo than that in vitro. In summary, the effects of different polymers and solvents on drug release and depot formation in ISFI systems were extensively investigated and discussed in this article. The two main factors, polymer permeability and solvent removal rate, were involved in different stages of drug release and depot formation in ISFI systems.

Drug release from enzyme-mediated in situ-forming hydrogel based on gum tragacanth–tyramine conjugate

2015 ◽  
Vol 29 (10) ◽  
pp. 1343-1350 ◽  
Author(s):  
Maryam Dehghan-Niri ◽  
Moslem Tavakol ◽  
Ebrahim Vasheghani-Farahani ◽  
Fariba Ganji
Keyword(s):  
Drug Release ◽  
Gum Tragacanth ◽  
In Situ Forming

Long-lasting in situ forming Implant loaded with Bupivacaine: Investigation on the Polymeric and Non-polymeric Carrier and Solvent Effect

2021 ◽  
Vol 18 ◽  
Author(s):  
Saeed Bazraee ◽  
Hamid Mobedi ◽  
Arezuo Mashak ◽  
Ahmad Jamshidi
Keyword(s):  
Drug Release ◽  
In Vitro Release ◽  
Fickian Diffusion ◽  
Morphological Properties ◽  
Burst Release ◽  
Solvent Concentration ◽  
Drug Release Profile ◽  
In Situ Forming

Introduction: Typically, in situ forming implants utilize Poly (lactide-co-glycolide) (PLGA) as a carrier and N-methyl-2-pyrrolidone (NMP) as a solvent. However, it is essential to develop different carriers to release various drugs in a controlled and sustained manner with economic and safety considerations. Objective: The present study aims to evaluate the in-vitro release of Bupivacaine HCl from in situ forming systems as post-operative local anesthesia. Methods: We used Sucrose acetate isobutyrate (SAIB), PLGA 50:50, and a mixture of them as carriers to compare the release behavior. Besides, the effect of PLGA molecular weight (RG 502H, RG 503H, and RG 504H), solvent type, and solvent concentration on the drug release profile was evaluated. The formulations were characterized by investigating their in-vitro drug release, rheological properties, solubility, and DSC, in addition to their morphological properties. Furthermore, the Korsmeyer-Peppas and Weibull models were applied to the experimental data. The results revealed that a mixture of SAIB and PLGA compared to using them solely can extend the Bupivacaine HCl release from 3 days to two weeks. Results: The DSC results demonstrated the compatibility of the mixture by showing a single Tg. The formulation with NMP had a higher burst release and final release in comparison with other solvents by 30% and 96%, respectively. Increasing the solvent concentration from 12% to 32% raised the drug release significantly, which confirmed the larger porosity in the morphology results. From the Korsmeyer-Peppas model, the mechanism of drug release is predicted to be non-Fickian diffusion.

scholarly journals Hydrophobic mixed solvent induced PLGA-based in situ forming systems for smooth long-lasting delivery of Radix Ophiopogonis polysaccharide in rats

RSC Advances ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. 5349-5361 ◽  
Author(s):  
LiNa Wang ◽  
Xiao Lin ◽  
YanLong Hong ◽  
Lan Shen ◽  
Yi Feng
Keyword(s):  
Drug Release ◽  
Mixed Solvent ◽  
Factors Affecting ◽  
In Situ Forming ◽  
Hydrophobic Solvent

To obtain a sustained in vivo release of Radix Ophiopogonis polysaccharide, hydrophobic solvent-induced in situ forming systems were investigated, including the factors affecting drug release and anti-myocardial ischemic activity of a formulation.

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