False‐positive pregnancy test secondary to ectopic expression of human chorionic gonadotropin by a gastrointestinal stromal tumor

Abstract Purpose The present systematic review aimed to examine the relationship between lung neoplasm and human chorionic gonadotropin (HCG). Especially, women with lung neoplasm mimicking as ectopic pregnancy were explored. Methods A rare case of lung neoplasm with high serum β-HCG, which was initially thought to be ectopic pregnancy, was reported. A literature search was performed of the US National Library of Medicine (MEDLINE), EMBASE, PubMed, and the Cochrane Database of Systematic Reviews using appropriate keywords and subject headings to February 2020. Results Studies assessed lung neoplasm patients with positive HCG were included. Twenty studies, including 24 patients, were included. These cases illustrate the importance of considering the possibility of paraneoplastic secretion of β-HCG in patients who have a positive pregnancy test. This may prevent a delay in the diagnosis and treatment of malignancy in young women. Of the 24 cases, only 7 (29.17%) were managed surgically; others were managed conservatively or with chemotherapy or radiation. Conclusion The present systematic review shows the need to re-awaken awareness and high index of suspicion to lung neoplasm diagnosis in patients with positive pregnancy test.

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The usefulness of testosterone administration in identifying false-positive elevation of serum human chorionic gonadotropin in patients with germ cell tumor

Journal of Cancer Research and Clinical Oncology ◽

10.1007/s00432-017-2520-5 ◽

2017 ◽

Vol 144 (1) ◽

pp. 109-115 ◽

Cited By ~ 4

Author(s):

Akitoshi Takizawa ◽

Koji Kawai ◽

Takashi Kawahara ◽

Takahiro Kojima ◽

Satoru Maruyama ◽

...

Keyword(s):

Germ Cell ◽

Germ Cell Tumor ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

False Positive ◽

Cell Tumor ◽

Testosterone Administration

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Quantitative automated human chorionic gonadotropin measurement in urine using the Modular Analytics E170 module (Roche)

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm.2005.010 ◽

2005 ◽

Vol 43 (1) ◽

Cited By ~ 12

Author(s):

Nasser E. Ajubi ◽

Nine Nijholt ◽

Albert Wolthuis

Keyword(s):

Pregnant Woman ◽

Detection Limit ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Storage Period ◽

Manual Labor ◽

Pregnancy Test ◽

Automated Methods ◽

Inter Assay Variation ◽

Analytical Detection

AbstractOngoing demands on laboratory performance require optimization of processes. An obvious way to achieve this is to reduce manual labor in favor of automated methods. We describe the validation of an automated quantitative urine human chorionic gonadotropin (hCG) analysis on the Roche Modular E170 analyzer to replace the manual qualitative pregnancy test in urine. At urine hCG concentrations of 476, 45 and 11U/L, we found inter-assay variation of 4.3%, 4.3% and 6.8% and average intra-assay variation of 3.0%, 2.6% and 3.0%, respectively. The analytical detection limit was 0.7U/L. We did not detect any loss (due to degradation or adsorption) during a storage period of 5days at 4°C or at −20°C. Recoveries of hCG in urine of a pregnant woman diluted with urine of a pre-menopausal non-pregnant woman (concentration range between 6 and 800mU/L) were between 93% and 112% (y=0.997x−3.843, r

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Post-molar Choriocarcinoma Prevention with MTX Treatment of Persistent Trophoblastic Disease

Journal of Clinical Cases & Reports ◽

10.46619/joccr.2019.2-1047 ◽

2019 ◽

Vol 2 (4) ◽

pp. 96-97

Author(s):

Maeda Kazuo ◽

Keyword(s):

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Pregnancy Test ◽

Trophoblastic Disease ◽

Case Number

Aim: Prevention of post molar choriocarcinoma. Methods: 70 mg Methotrexate (MTX) was administered all post molar cases, whose urinary pregnancy test was negative, while 200-300 mg MTX was administered to two persistent trophoblastic disease, whose pregnancy test was positive by human chorionic gonadotropin (hCG). Control was 37 post molar cases, who received no MTX. Post molar examination were repeated in both groups. Results: No choriocarcinoma developed in 107 MTX group, while 3 cases developed choriocarcinoma in 37 nonMTX group. Choriocarcinoma case number was significantly less in MTX groups.

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