scholarly journals Lung neoplasm mimicking as ectopic pregnancy due to paraneoplastic secretion of human chorionic gonadotropin: a case report and literature review

2021 ◽  
Author(s):  
Jin Peng ◽  
Shangge lv ◽  
Lin Liu ◽  
Shuai Feng ◽  
Naidong Xing
Keyword(s):  
Systematic Review ◽  
Ectopic Pregnancy ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Lung Neoplasm ◽  
High Serum ◽  
Pregnancy Test ◽  
Positive Pregnancy Test ◽  
Β Hcg ◽  
Present Systematic Review

Abstract Purpose The present systematic review aimed to examine the relationship between lung neoplasm and human chorionic gonadotropin (HCG). Especially, women with lung neoplasm mimicking as ectopic pregnancy were explored. Methods A rare case of lung neoplasm with high serum β-HCG, which was initially thought to be ectopic pregnancy, was reported. A literature search was performed of the US National Library of Medicine (MEDLINE), EMBASE, PubMed, and the Cochrane Database of Systematic Reviews using appropriate keywords and subject headings to February 2020. Results Studies assessed lung neoplasm patients with positive HCG were included. Twenty studies, including 24 patients, were included. These cases illustrate the importance of considering the possibility of paraneoplastic secretion of β-HCG in patients who have a positive pregnancy test. This may prevent a delay in the diagnosis and treatment of malignancy in young women. Of the 24 cases, only 7 (29.17%) were managed surgically; others were managed conservatively or with chemotherapy or radiation. Conclusion The present systematic review shows the need to re-awaken awareness and high index of suspicion to lung neoplasm diagnosis in patients with positive pregnancy test.

False-positive pregnancy test after passive transfusion of ?-human chorionic gonadotropin from donor red blood cells during erythrocytapheresis

Transfusion ◽  
2007 ◽  
Vol 47 (5) ◽  
pp. 788-791 ◽  
Author(s):  
Suresh G. Shelat ◽  
David F. Friedman ◽  
Geralyn M. Meny ◽  
Kim Smith-Whitley ◽  
Dean Carlow ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
False Positive ◽  
Blood Cells ◽  
Pregnancy Test ◽  
Positive Pregnancy Test

scholarly journals A Case of Successful Laparoscopic Surgery for Tubal Stump Pregnancy after Tubectomy

2015 ◽  
Vol 8 ◽  
pp. CCRep.S20907 ◽  
Author(s):  
Masakazu Nishida ◽  
Yuko Miyamoto ◽  
Yasushi Kawano ◽  
Kanetoshi Takebayashi ◽  
Hisashi Narahara
Keyword(s):  
Laparoscopic Surgery ◽  
Ectopic Pregnancy ◽  
Fallopian Tube ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Japanese Woman ◽  
Positive Pregnancy Test ◽  
Old Japanese ◽  
Gestational Sac ◽  
Ectopic Pregnancies

The incidence of ectopic pregnancy is approximately 1.3∼2% of all pregnancies, and more than 90% of ectopic pregnancies are detected in the ampulla of the fallopian tube. Ectopic pregnancy occurring in tubal stump after tubectomy is extremely rare, and the frequency of tubal stump pregnancy is approximately 0.4% of all pregnancies. We report one of these rare cases of ectopic pregnancy in a 26-year-old Japanese woman, gravida 4, parity 1. She had undergone laparoscopic tubectomy because of a tubal pregnancy two years ago. She was presented to our hospital with a positive pregnancy test, but no gestational sac was detected in the uterus by echography, even though the level of human chorionic gonadotropin (hCG) in the blood was elevated to 8,900 mIU/mL. Laparoscopic surgery for ectopic pregnancy was performed. During surgery, the position of the pregnancy was found to be in the tubal stump, where tubectomy had already been performed, and the gestational sac was successfully removed. After the surgery, the condition of the patient uneventfully improved and she was discharged from the hospital three days after the surgery. The diagnosis of tubal stump pregnancy is more difficult than that of the more common positions of an ectopic pregnancy in the fallopian tube, and so it is more important to carefully examine the patients with suspected ectopic pregnancy. Laparoscopic surgery is one of the options for tubal stump pregnancy if diagnosed early and if the condition of the patient is stable.

scholarly journals False Positive Pregnancy Test and Ectopic Human Chorionic Gonadotropin with Large Cell Lung Cancer in a Young Woman.

Haigan ◽  
2000 ◽  
Vol 40 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Satoshi Hara ◽  
Takeshi Hirohata ◽  
Hiroshi Otsuka ◽  
Kenji Minami ◽  
Hiroshi Tsuda ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Young Woman ◽  
Chorionic Gonadotropin ◽  
Cell Lung Cancer ◽  
Human Chorionic Gonadotropin ◽  
False Positive ◽  
Large Cell ◽  
Pregnancy Test ◽  
Positive Pregnancy Test ◽  
Large Cell Lung Cancer

scholarly journals Human Chorionic Gonadotropin Isoforms in the Diagnosis of Ectopic Pregnancy

2003 ◽  
Vol 49 (12) ◽  
pp. 2045-2049 ◽  
Author(s):  
Paola T A Borrelli ◽  
Stephen A Butler ◽  
Suzanne M Docherty ◽  
Edyta M Staite ◽  
Antonio L Borrelli ◽  
...  
Keyword(s):  
Ectopic Pregnancy ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Lower Abdominal Pain ◽  
Serum Samples ◽  
Spontaneous Miscarriage ◽  
Positive Pregnancy Test ◽  
Ectopic Pregnancies ◽  
Time Of Presentation ◽  
Serial Measurements

Abstract Background: Early diagnosis of ectopic pregnancy uses ultrasound with serial measurements of total human chorionic gonadotropin (hCG). The objective of this study was to explore the possibility that an isolated measurement of hCG isoforms/subunits rather than total hCG could be used as a single test for ectopic pregnancy. Methods: Total and intact hCG, free hCG β- and α-subunits (hCGβ and -α), and hCG β-core fragment were measured by RIA and IRMA in the serum and urine of 76 women presenting at outpatient emergency departments with a positive pregnancy test, lower abdominal pain, and/or vaginal bleeding. Final diagnoses were based on outcomes of pregnancies and tissue histology. Results: Twenty-seven of the 76 women were subsequently diagnosed with viable pregnancies, 37 with spontaneous miscarriage, and 12 with ectopic pregnancy. Concentrations of all forms of hCG were lower in cases of ectopic pregnancy and spontaneous miscarriage than in viable pregnancies. Serum samples gave better results than urine samples. The free hCGβ isoform (P <0.0001) had 100% sensitivity at a specificity of 79% at a 281 pmol/L (6.5 μg/L) cutoff. Total hCG (P = 0.005) had comparable ROC characteristics with a 100% sensitivity and 68% specificity at a cutoff value of 1053 pmol/L (375 IU/L). Neither hCGβ (P = 0.7) nor total hCG (P = 0.4) could distinguish ectopic pregnancies from spontaneous miscarriage. Conclusion: Measurement of serum free hCGβ at the time of presentation can identify women with a high probability of ectopic pregnancy who may benefit from closer surveillance, reducing the risk of tubal rupture.

scholarly journals A Ruptured Ectopic Pregnancy Presenting with a Negative Urine Pregnancy Test

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Johnathan Michael Sheele ◽  
Rachel Bernstein ◽  
Francis L. Counselman
Keyword(s):  
Emergency Department ◽  
Ectopic Pregnancy ◽  
Chorionic Gonadotropin ◽  
Early Pregnancy ◽  
Human Chorionic Gonadotropin ◽  
Rare Case ◽  
Obstetrics And Gynecology ◽  
Pregnancy Test ◽  
Beta Human Chorionic Gonadotropin ◽  
Urine Pregnancy Test

A negative urine pregnancy test in the emergency department traditionally excludes the diagnosis of pregnancy. We report a rare case of ruptured ectopic pregnancy in a patient with a negative urine pregnancy test but with a serum beta-human chorionic gonadotropin (β-hCG) of 10 mIU/mL. The patient developed hemoperitoneum and required laparoscopy by Obstetrics and Gynecology (OB/Gyn). This case highlights the fallibility of the urine pregnancy test in diagnosing early pregnancy.

scholarly journals Ectopic Pregnancy at 13-week Period of Gestation with Live Fetus

2018 ◽  
Vol 17 (4) ◽  
pp. 99-102
Author(s):  
Konstantinos Zacharis ◽  
Stavros Kravvaritis ◽  
Theodoros Charitos ◽  
Anastasia Fouka
Keyword(s):  
Ectopic Pregnancy ◽  
Clinical Presentation ◽  
Ultrasound Examination ◽  
Hemodynamic Instability ◽  
Sonographic Examination ◽  
Pregnancy Test ◽  
Positive Pregnancy Test ◽  
Β Hcg ◽  
Live Fetus ◽  
Period Of Gestation

Ectopic pregnancy will unavoidably result in abortion or rupture. Ultrasound examination and β-hcg measurement are required, regarding symptomatic women with positive pregnancy test, in order to early detect cases of ectopic pregnancy. Here we report a case of a woman presented to the emergency depart- ment with acute abdomen and hemodynamic instability. History revealed a period of amenorrhea of 13 weeks and pregnancy test was found positive. Sonographic examination showed left adnexal swelling with viable fetus inside, hemoperitoneum and thus immediate laparotomy was decided. Left salpingo-oophorec- tomy was performed and post-operative course of the patient was uneventful. According to this case, ec- topic pregnancy should not be eliminated from differential diagnosis when it comes to pregnant women with relevant clinical presentation, even in advanced gestational age.

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