scholarly journals Optimized Anti–Prostate‐Specific Membrane Antigen Single‐Chain Variable Fragment–Loaded Nanobubbles as a Novel Targeted Ultrasound Contrast Agent for the Diagnosis of Prostate Cancer

2019 ◽  
Vol 39 (4) ◽  
pp. 761-773 ◽  
Author(s):  
Yu Ding ◽  
Qifeng Cao ◽  
Subo Qian ◽  
Xiaolong Chen ◽  
Yuhong Xu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Contrast Agent ◽  
Ultrasound Contrast Agent ◽  
Prostate Specific Membrane Antigen ◽  
Single Chain Variable Fragment ◽  
Single Chain ◽  
Ultrasound Contrast ◽  
Targeted Ultrasound ◽  
Specific Membrane

In Vitro Evaluation of Ultrasound-Assisted Thrombolysis Using a Targeted Ultrasound Contrast Agent

2009 ◽  
Vol 31 (4) ◽  
pp. 235-246 ◽  
Author(s):  
Szu-Chia Chen ◽  
Jia-Ling Ruan ◽  
Po-Wen Cheng ◽  
Yueh-Hsun Chuang ◽  
Pai-Chi Li
Keyword(s):  
Contrast Agent ◽  
Weight Reduction ◽  
Ultrasound Contrast Agent ◽  
High Frequency Ultrasound ◽  
Ultrasound Frequency ◽  
Ultrasound Contrast ◽  
Targeted Ultrasound ◽  
Targeted Microbubbles ◽  
Ultrasound Assisted

A thrombus-targeted ultrasound contrast agent bound with tirofiban — a glycoprotein (GP) IIb/IIIa antagonist that can specifically bind to activated platelets in the thrombus — was designed to enhance both the image contrast and thrombolysis effect. In this study, we used 76 canine thrombi for investigation. The targeting ability to thrombi was confirmed by microphotography and high-frequency ultrasound (40 MHz) imaging. The effect of the targeted microbubbles on thrombolysis enhancement was investigated using an in vitro flow system: targeted and nontargeted microbubbles flowed through the clot for 30 seconds with a washing step; the microbubbles remained on the clot that were then cavitated by ultrasound (frequency = 1 MHz, MI = 1.2). The extent of thrombolysis was evaluated by weight reduction and histology analysis. The targeted microbubbles reduced the weight of thrombi by a factor of 1.7 times that of the nontargeted microbubbles. (clot weight reduction: 23.1 ± 5.3% versus 13.6 ± 4.9%, p < 0.01 between targeted and nontargeted group), and the signal enhancement was 3.34 ± 0.30 dB (mean ± SD, p < 0.01 compared to control). We conclude that targeted microbubbles are applicable not only for molecular imaging of thrombi but also for improving the effectiveness of ultrasound-assisted thrombolysis.

scholarly journals RGD-Targeted Ultrasound Contrast Agent for Longitudinal Assessment of Hep-2 Tumor Angiogenesis In Vivo

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0149075 ◽  
Author(s):  
Qiao Hu ◽  
Xiao-Yan Wang ◽  
Li-Ke Kang ◽  
Hai-Ming Wei ◽  
Chun-Mei Xu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Tumor Angiogenesis ◽  
Ultrasound Contrast Agent ◽  
Longitudinal Assessment ◽  
Ultrasound Contrast ◽  
Targeted Ultrasound

Unbinding of targeted ultrasound contrast agent microbubbles by secondary acoustic forces

2011 ◽  
Vol 56 (19) ◽  
pp. 6161-6177 ◽  
Author(s):  
Valeria Garbin ◽  
Marlies Overvelde ◽  
Benjamin Dollet ◽  
Nico de Jong ◽  
Detlef Lohse ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Ultrasound Contrast Agent ◽  
Ultrasound Contrast ◽  
Targeted Ultrasound

scholarly journals Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow

2006 ◽  
Vol 1 (6) ◽  
pp. 259-266 ◽  
Author(s):  
A. L. Klibanov ◽  
J. J. Rychak ◽  
W. C. Yang ◽  
S. Alikhani ◽  
B. Li ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Shear Flow ◽  
Contrast Agent ◽  
Ultrasound Contrast Agent ◽  
High Shear ◽  
Ultrasound Contrast ◽  
Targeted Ultrasound

A novel dual-targeted ultrasound contrast agent provides improvement of gene delivery efficiency in vitro

Tumor Biology ◽  
2016 ◽  
Vol 37 (7) ◽  
pp. 8609-8619 ◽  
Author(s):  
Jinfeng Xu ◽  
Xinxin Zeng ◽  
Yingying Liu ◽  
Hui Luo ◽  
Zhanghong Wei ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Contrast Agent ◽  
Ultrasound Contrast Agent ◽  
Ultrasound Contrast ◽  
Targeted Ultrasound ◽  
Delivery Efficiency
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