Breaking Acoustic Limit of Optical Focusing Using Photoacoustic‐Guided Wavefront Shaping

2021 ◽  
pp. 2000594
Author(s):  
Rongkang Gao ◽  
Zhiqiang Xu ◽  
Liang Song ◽  
Chengbo Liu
2017 ◽  
Vol 111 (22) ◽  
pp. 221109 ◽  
Author(s):  
Ashton S. Hemphill ◽  
Yuecheng Shen ◽  
Yan Liu ◽  
Lihong V. Wang

Science ◽  
2019 ◽  
Vol 363 (6426) ◽  
pp. 528-531 ◽  
Author(s):  
Donggyu Kim ◽  
Dirk R. Englund

Optical scattering is generally considered to be a nuisance of microscopy that limits imaging depth and spatial resolution. Wavefront shaping techniques enable optical imaging at unprecedented depth, but attaining superresolution within complex media remains a challenge. We used a quantum reference beacon (QRB), consisting of solid-state quantum emitters with spin-dependent fluorescence, to provide subwavelength guidestar feedback for wavefront shaping to achieve a superresolution optical focus. We implemented the QRB-guided imaging with nitrogen-vacancy centers in diamond nanocrystals, which enable optical focusing with a subdiffraction resolution below 186 nanometers (less than half the wavelength). QRB-assisted wavefront-shaping should find use in a range of applications, including deep-tissue quantum enhanced sensing and individual optical excitation of magnetically coupled spin ensembles for applications in quantum information processing.


2015 ◽  
Vol 9 (2) ◽  
pp. 126-132 ◽  
Author(s):  
Puxiang Lai ◽  
Lidai Wang ◽  
Jian Wei Tay ◽  
Lihong V. Wang

2015 ◽  
Vol 08 (02) ◽  
pp. 1550007 ◽  
Author(s):  
Qiang Yang ◽  
Xinzhu Sang ◽  
Daxiong Xu

Focusing light though scattering media beyond the ballistic regime is a challenging task in biomedical optical imaging. This challenge can be overcome by wavefront shaping technique, in which a time-reversed (TR) wavefront of scattered light is generated to suppress the scattering. In previous TR optical focusing experiments, a phase-only spatial light modulator (SLM) has been typically used to control the wavefront of incident light. Unfortunately, although the phase information is reconstructed by the phase-only SLM, the amplitude information is lost, resulting in decreased peak-to-background ratio (PBR) of optical focusing in the TR wavefront reconstruction. A new method of TR optical focusing through scattering media is proposed here, which numerically reconstructs the full phase and amplitude of a simulated scattered light field by using a single phase-only SLM. Simulation results and the proposed optical setup show that the time-reversal of a fully developed speckle field can be digitally implemented with both phase and amplitude recovery, affording a way to improve the performance of light focusing through scattering media.


2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Zhongtao Cheng ◽  
Lihong V. Wang

AbstractFocusing light into scattering media, although challenging, is highly desirable in many realms. With the invention of time-reversed ultrasonically encoded (TRUE) optical focusing, acousto-optic modulation was demonstrated as a promising guidestar mechanism for achieving noninvasive and addressable optical focusing into scattering media. Here, we report a new ultrasound-assisted technique, ultrasound-induced field perturbation optical focusing, abbreviated as UFP. Unlike in conventional TRUE optical focusing, where only the weak frequency-shifted first-order diffracted photons due to acousto-optic modulation are useful, here UFP leverages the brighter zeroth-order photons diffracted by an ultrasonic guidestar as information carriers to guide optical focusing. We find that the zeroth-order diffracted photons, although not frequency-shifted, do have a field perturbation caused by the existence of the ultrasonic guidestar. By detecting and time-reversing the differential field of the frequency-unshifted photons when the ultrasound is alternately ON and OFF, we can focus light to the position where the field perturbation occurs inside the scattering medium. We demonstrate here that UFP optical focusing has superior performance to conventional TRUE optical focusing, which benefits from the more intense zeroth-order photons. We further show that UFP optical focusing can be easily and flexibly developed into double-shot realization or even single-shot realization, which is desirable for high-speed wavefront shaping. This new method upsets conventional thinking on the utility of an ultrasonic guidestar and broadens the horizon of light control in scattering media. We hope that it provides a more efficient and flexible mechanism for implementing ultrasound-guided wavefront shaping.


2014 ◽  
Author(s):  
Puxiang Lai ◽  
Jian Wei Tay ◽  
Lidai Wang ◽  
Lihong V. Wang

2020 ◽  
Vol 28 (7) ◽  
pp. 9823
Author(s):  
Marco A. Inzunza-Ibarra ◽  
Evolene Premillieu ◽  
Clemens Grünsteidl ◽  
Rafael Piestun ◽  
Todd W. Murray

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