Liver Imaging Reporting and Data System Version 2018: Impact on Categorization and Hepatocellular Carcinoma Staging

2019 ◽  
Vol 25 (10) ◽  
pp. 1488-1502 ◽  
Author(s):  
Victoria Chernyak ◽  
Milana Flusberg ◽  
Jesse Berman ◽  
Kate C. Fruitman ◽  
Mariya Kobi ◽  
...  
2020 ◽  
Vol 30 (1) ◽  
pp. 261-271 ◽  
Author(s):  
Nieun Seo ◽  
Myoung Soo Kim ◽  
Mi-Suk Park ◽  
Jin-Young Choi ◽  
Richard K. G. Do ◽  
...  

Author(s):  
Hang Zhou ◽  
Chao Zhang ◽  
Linyao Du ◽  
Jiapeng Jiang ◽  
Qing Zhao ◽  
...  

Abstract Objectives To determine the diagnostic performance and inter-reader agreement of the contrast-enhanced ultrasound liver imaging reporting and data system (CEUS-LI-RADS) for diagnosing hepatocellular carcinoma (HCC) in high-risk patients. Methods In this prospective study, CEUS-LI-RADS categories (LR-5 for predicting HCC) were assigned by six blinded readers and compared to the definitive HCC diagnosis in patients with liver cirrhosis per the 2017 China Liver Cancer Guidelines (CLCG). CEUS features were recorded in 96 patients with 96 histology-proven lesions. The diagnostic performance of LR-5 was described by the sensitivity, specificity and accuracy. Multi-reader agreement was assessed by using intraclass correlation coefficients (ICC). Results In cirrhotic patients, the specificity of LR-5 (range: 92.7–100.0 %) was statistically higher than that of CLCG for each reader (range: 28.6–64.3 %). However, the sensitivity (range: 38.6–63.6 %) and accuracy (range: 53.4–70.7 %) were statistically lower in CEUS-LIRADS than in CLCG (sensitivity range: 88.6–100.0 %; accuracy range: 77.6–86.2 %). Only fair to moderate inter-reader agreement was achieved for the CEUS-LI-RADS category (ICC = 0.595) and washout appearance (ICC range: 0.338 to 0.555). Neither nodule-in-nodule nor mosaic architecture was observed more often in HCC (all P > 0.05), with poor inter-reader consistency for both (both ICC < 0.20). Conclusion CEUS-LI-RADS category 5 has a high specificity but a low accuracy for identifying HCC in high-risk patients. Inter-reader agreement is not satisfactory concerning CEUS-LIRADS category and washout appearance. Moreover, the clinical value of ancillary features favoring HCC is quite limited.


2020 ◽  
Vol 75 (6) ◽  
pp. 478.e25-478.e35 ◽  
Author(s):  
A.-H. Ren ◽  
J.-B. Du ◽  
D.-W. Yang ◽  
P.-F. Zhao ◽  
Z.-C. Wang ◽  
...  

2020 ◽  
Vol 17 (10) ◽  
pp. 1199-1206 ◽  
Author(s):  
Sunyoung Lee ◽  
Yeun-Yoon Kim ◽  
Jaeseung Shin ◽  
Shin Hye Hwang ◽  
Yun Ho Roh ◽  
...  

2017 ◽  
Vol 43 (1) ◽  
pp. 41-55 ◽  
Author(s):  
Tara A. Morgan ◽  
◽  
Katherine E. Maturen ◽  
Nirvikar Dahiya ◽  
Maryellen R. M. Sun ◽  
...  

2021 ◽  
Author(s):  
HuiFang Li ◽  
Wei Huang ◽  
Wei Zheng ◽  
Qing Li ◽  
YunZhu Dai ◽  
...  

Abstract Background: Contrast-enhanced Ultrasonography Liver Imaging Reporting and Data System (CEUS LI-RADS) released by American College of Radiology was a widely used reporting system for patients at risk with hepatocellular carcinoma (HCC). In CEUS LI-RADS, the categories range from definitely benign (LR-1), probably begin (LR-2), intermediate probability of malignancy (LR-3), probably HCC (LR-4) to definitely HCC (LR-5), malignancy (LR-M), or definite tumor in vein (LR-TIV). Methods: We searched MEDLINE, Web of Science, Cochrane, Embase, and Chinese databases to obtain eligible studies reporting on the diagnostic performance of CEUS LI-RADS in patients at risk for HCC. Results: Twelve studies were eligible in the analysis, including 5275 patients, 5739 observations, and 4066 HCCs. The pooled sensitivity and specificity were 70% (95% Confidence Interval [CI] 65%-74%), 94% (95% CI, 91%-96%) of LR-5 category as predictors of HCC, respectively. The pooled sensitivity and specificity of LR-M category as a predictor of non-HCC malignancy were 83% (95% CI, 71%-91%), 94% (95% CI 88%-97%), respectively. The pooled proportions of HCCs were 1% (95% CI 0%-6%) for LR-2, 20% (95% CI, 9%-34%) for LR-3, 78% (95% CI, 67%-88%) for LR-4, 97% (95% CI, 94%-99%) for LR-5, 40% (95% CI, 23%–58%) for LR-M and 100% (95% CI, 93%–100%) for LR-TIV.Conclusion: CEUS LI-RADS is an important tool for the diagnosis of HCC.


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