Biodegradable polymeric matrix for long-acting and zero-order release drug delivery systems

1990 ◽  
Vol 33 (1) ◽  
pp. 253-264 ◽  
Author(s):  
You-Xin Li ◽  
Xin-De Feng
Author(s):  
Arvind Kumar Singh Chandel

The term control release means the release of the molecules from any reservoir in very precise and constant amounts and following zero-order or near-to-zero-order release kinetics. This type of formulation and device has a huge market over the medical world. The basic foundation of sustained release drug delivery system enhances the biopharmaceutical and pharmacodynamics pharmacokinetic properties of a drug in such a way that its usefulness is exploited, side-effects are reduced, and cure of the disease is attained easily. The international controlled-release drug delivery technology market has been divided on the basis of technology, application, release mechanism, and geography. This chapter describes these topics: metered dose inhalers, transdermal and ocular patches, drug eluting stents, activation-modulated drug delivery systems, polymer coating systems microelectromechanical technology, implants, micro reservoir partition controlled drug delivery systems, hydrophilic polymer matrix systems, targeted delivery, enzyme activated device.


2021 ◽  
Vol 28 ◽  
Author(s):  
Aleksandra Zielińska ◽  
Piotr Eder ◽  
Lucas Rannier ◽  
Juliana C. Cardoso ◽  
Patrícia Severino ◽  
...  

Abstract: Hydrogels for the modified-release drug delivery systems is a continuously growing area of interest for the pharmaceutical industry. According to the global market, the use of polymers in this area is projected to reach $31.4 million by 2027. This review discusses the recent advances and perspectives of hydrogel in drug delivery systems for oral, parenteral, nasal, topical, and ophthalmic. The search strategy did in January 2021, and it conducted an extensive database to identify studies published from January 2010 to December 2020.We described the main characteristic of the polymers to obtain an ideal hydrogel for a specific route of administration and the formulations that was a highlight in the literature. It concluded that the hydrogels are a set useful to decrease the number of doses, side effects, promote adhesion of patient and enhances the bioavailability of the drugs improving the safety and efficacy of the treatment.


2022 ◽  
pp. 203-222
Author(s):  
Vanteemar S. Sreeraj ◽  
Venkataram Shivakumar ◽  
Naren P. Rao ◽  
Ganesan Venkatasubramanian

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