Background. The beta-2 adrenergic receptor is expressed by neoplastic cells and is correlated with a wide spectrum of tumor cell mechanisms including proliferation, apoptosis, angiogenesis, migration, and metastasis.Objectives. The present study aimed to analyze the expression of the beta-2 adrenergic receptor (β2-AR) in tumor-free surgical margins of oral squamous cell carcinomas (OSCC) and at the invasive front. Sixty-two patients diagnosed with OSCC, confirmed by biopsy, were selected for the study. The clinicopathological data and clinical follow-up were obtained from medical records and their association withβ2-AR expression was verified by the chi-square test or Fischer’s exact test. To verify the correlation ofβ2-AR expression in tumor-free surgical margins and at the invasive front of OSCCs, Pearson’s correlation coefficient test was applied.Results. The expression ofβ2-AR presented a statistically significant correlation between the tumor-free surgical margins and the invasive front of OSCC (r=0.383;p=0.002). The immunohistochemical distribution ofβ2-AR at the invasive front of OSCC was also statistically significant associated with alcohol (p=0.038), simultaneous alcohol and tobacco consumption (p=0.010), and T stage (p=0.014).Conclusions. The correlation ofβ2-AR expression in OSCC and tumor-free surgical margins suggests a role of this receptor in tumor progression and its expression in normal oral epithelium seems to be constitutive.
Suppression of beta 2 adrenergic receptor actions prevent UVB mediated cutaneous squamous cell tumorigenesis through inhibition of VEGF‐A induced angiogenesis
