scholarly journals Correlation of Beta-2 Adrenergic Receptor Expression in Tumor-Free Surgical Margin and at the Invasive Front of Oral Squamous Cell Carcinoma

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Denise Tostes Oliveira ◽  
Diego Mauricio Bravo-Calderón ◽  
Gustavo Amaral Lauand ◽  
Agnes Assao ◽  
José-Manuel Suárez-Peñaranda ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Adrenergic Receptor ◽  
Wide Spectrum ◽  
Surgical Margin ◽  
Tobacco Consumption ◽  
Receptor Expression ◽  
Surgical Margins ◽  
Oral Epithelium ◽  
Invasive Front ◽  
Beta 2

Background. The beta-2 adrenergic receptor is expressed by neoplastic cells and is correlated with a wide spectrum of tumor cell mechanisms including proliferation, apoptosis, angiogenesis, migration, and metastasis.Objectives. The present study aimed to analyze the expression of the beta-2 adrenergic receptor (β2-AR) in tumor-free surgical margins of oral squamous cell carcinomas (OSCC) and at the invasive front. Sixty-two patients diagnosed with OSCC, confirmed by biopsy, were selected for the study. The clinicopathological data and clinical follow-up were obtained from medical records and their association withβ2-AR expression was verified by the chi-square test or Fischer’s exact test. To verify the correlation ofβ2-AR expression in tumor-free surgical margins and at the invasive front of OSCCs, Pearson’s correlation coefficient test was applied.Results. The expression ofβ2-AR presented a statistically significant correlation between the tumor-free surgical margins and the invasive front of OSCC (r=0.383;p=0.002). The immunohistochemical distribution ofβ2-AR at the invasive front of OSCC was also statistically significant associated with alcohol (p=0.038), simultaneous alcohol and tobacco consumption (p=0.010), and T stage (p=0.014).Conclusions. The correlation ofβ2-AR expression in OSCC and tumor-free surgical margins suggests a role of this receptor in tumor progression and its expression in normal oral epithelium seems to be constitutive.

scholarly journals Suppression of beta 2 adrenergic receptor actions prevent UVB mediated cutaneous squamous cell tumorigenesis through inhibition of VEGF‐A induced angiogenesis

2021 ◽  
Vol 60 (3) ◽  
pp. 172-178
Author(s):  
Kai Lu ◽  
Madhavi Bhat ◽  
Sara Peters ◽  
Rita Mitra ◽  
Tatiana Oberyszyn ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Adrenergic Receptor ◽  
Beta 2

scholarly journals Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization.

1987 ◽  
Vol 84 (20) ◽  
pp. 6995-6999 ◽  
Author(s):  
L. J. Emorine ◽  
S. Marullo ◽  
C. Delavier-Klutchko ◽  
S. V. Kaveri ◽  
O. Durieu-Trautmann ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Expression ◽  
Promoter Characterization ◽  
Beta 2

Prognostic significance of beta-2 adrenergic receptor in oral squamous cell carcinoma

2012 ◽  
Vol 10 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Diego Mauricio Bravo-Calderón ◽  
Denise Tostes Oliveira ◽  
Aparecido Nilceu Marana ◽  
Suely Nonogaki ◽  
André Lopes Carvalho ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adrenergic Receptor ◽  
Prognostic Significance ◽  
Beta 2

scholarly journals Accuracy of Frozen Section Examination in Oral Cavity Cancers

2020 ◽  
pp. 014556132096733
Author(s):  
Berat Demir ◽  
Sefa Incaz ◽  
Esin Irem Uckuyulu ◽  
Cagatay Oysu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Squamous Cell ◽  
Predictive Value ◽  
Frozen Section ◽  
Surgical Margin ◽  
Surgical Margins ◽  
Frozen Section Examination ◽  
Oral Cavity Cancers

Purpose: This study aimed to compare the intraoperative frozen section with the surgical margin in the postoperative surgical margins of the postoperative pathology of oral squamous cell carcinomas in order to examine the reliability of the frozen section. Methods: A retrospective analysis was conducted for patients who underwent surgery for oral squamous cell carcinoma in a tertiary hospital between January 2018 and 2019. The intraoperative frozen section examinations, grade of the tumor, number of lymph nodes, number of affected lymph nodes, depth of invasion, perineural invasion, lymphovascular invasion, and extranodal extension were recorded from the pathological records. The concordance between the frozen section examination and postoperative pathology 2 methods was examined using the Cronbach α coefficient. Sensitivity, specificity, positive predictive value, negative predictive value regarding surgical margins, and accuracy were calculated and reported. Results: Overall, 181patients who underwent surgery for oral cavity cancers were included; 118 (65.2%) were males. The mean (± standard deviation) age of the included participants was 57.4 ± 16.1 years. The most common tumour subsite was the tongue (n = 71, 39.2%). There was concordancy between the frozen, positive intraoperative malignancy and the postoperative pathology malignancy. The frozen, negative intraoperative malignancy and postoperative safe surgical margin did not significantly differ. Conclusion: As a result of intraoperative frozen examination, we found conformity between the postoperative pathology results of patients with positive and negative surgical margins. Frozen section examination could be used safely to examine intraoperative surgical margins of oral squamous cell carcinoma.

Abstract MP26: Angiotensin-(1-7) Increases Vascular Beta-2 Adrenergic Receptor Expression In Aging Mice

Hypertension ◽  
2021 ◽  
Vol 78 (Suppl_1) ◽  
Author(s):  
Amanda J Miller ◽  
Sarah Bingaman ◽  
Amy Arnold
Keyword(s):  
Gene Expression ◽  
Blood Pressure ◽  
Thoracic Aorta ◽  
Adrenergic Receptor ◽  
Cardiac Tissue ◽  
Sympathetic Tone ◽  
Receptor Expression ◽  
Separate Experiment ◽  
Ici 118,551 ◽  
Beta 2

Aging is associated with increased sympathetic tone, which desensitizes vascular beta-2 adrenergic receptors (B2AR) to impair vasodilation and promote hypertension. We recently demonstrated that chronic treatment with angiotensin (Ang)-(1-7), a protective hormone of the renin-angiotensin system, decreases blood pressure and cardiac sympathetic tone in aging mice. In this study, we hypothesized that sympathoinhibitory effects of Ang-(1-7) would restore vascular B2AR expression to lower blood pressure in aging. To test this, aging (16-month-old) and young (2-month-old) male C57BL/6J mice received Ang-(1-7) [400 ng/kg/min, n=4] or saline (n=4) infusion for 6 weeks via subcutaneous osmotic mini-pump. At end of treatment, alpha- and beta-adrenergic receptor gene expression was measured in mesenteric arteries, thoracic aorta, and cardiac tissue by quantitative real-time PCR and quantified with 2-ΔΔCT methods. In a separate experiment, male C57BL/6J mice received a single subcutaneous injection of Ang-(1-7) (2 mg/mg, n=4), saline (n=3), or the B2AR antagonist ICI 118,551 (1 mg/kg) plus Ang-(1-7) (n=3). Blood pressure was measured via a carotid artery catheter at baseline and post-treatment. We found that aging mice have decreased mesenteric B2AR gene expression, which was restored by Ang-(1-7) (young saline: 1.04±0.35; aged saline: 0.46±0.17; aged Ang-(1-7): 1.04±0.31 A.U., p=0.026). As a control, Ang-(1-7) did not induce significant changes in B2AR mRNA in thoracic aorta or cardiac tissue, or changes in other adrenergic receptor subtypes (alpha1 or beta1) in any of the tissues studied in aging mice (p>0.05). We further found that depressor effects of acute Ang-(1-7) in mice are attenuated by B2AR blockade (saline: Δ -11±4 mmHg; Ang-(1-7): Δ -26±3 mmHg; ICI 118,551+Ang-(1-7): Δ -4±4 mmHg, p=0.009). Overall, these findings suggest that Ang-(1-7) restores B2AR expression in mesenteric resistance vessels in aging mice, and depressor effects of acute Ang-(1-7) are partially mediated by B2AR. These data support the concept that Ang-(1-7) decreases blood pressure in aging by restoring B2AR-mediated vasodilation. More broadly, Ang-(1-7) may provide a novel treatment target for age-related hypertension and cardiovascular disease.

scholarly journals Prognostic and Predictive Impact of Beta-2 Adrenergic Receptor Expression in HER2-Positive Breast Cancer

2020 ◽  
Vol 20 (3) ◽  
pp. 262-273.e7
Author(s):  
Rafael Caparica ◽  
François Richard ◽  
Mariana Brandão ◽  
Ahmad Awada ◽  
Christos Sotiriou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adrenergic Receptor ◽  
Receptor Expression ◽  
Her2 Positive ◽  
Her2 Positive Breast Cancer ◽  
Beta 2 ◽  
Positive Breast Cancer

p53 Immunostaining of Surgical Margins as a Predictor of Local Recurrence in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx

1997 ◽  
Vol 76 (11) ◽  
pp. 818-823 ◽  
Author(s):  
Valerie A. Ball ◽  
Paul D. Righi ◽  
Eduardo Tejada ◽  
Shokri Radpour ◽  
Zlatko P. Pavelic ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Local Recurrence ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
P53 Protein ◽  
Surgical Margin ◽  
Surgical Margins ◽  
Positive Surgical Margin ◽  
Ratio Test

Local and regional recurrence is the principal reason for treatment failure in squamous cell carcinoma (SCC) of the head and neck. The conventional method of evaluating surgical margins for cellular atypia does not always predict risk of local recurrence accurately. Immunostaining of surgical margins for tumor markers may provide a more precise evaluation of risk of local recurrence. Paraffin-embedded tissue blocks of surgical margins from 24 patients with oral cavity and oropharyngeal squamous cell carcinoma were immunostained for p53 protein. Fifty-eight percent of the patients had at least one margin stain positive for p53, including eight often patients whose SCC recurred locally. The sample odds ratio test predicted a 5.333 times higher chance of local recurrence with at least one p53 positive surgical margin. The implications of these results for patient management and further investigations will be discussed.

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