Repeated oral administration modulates the pharmacokinetic behavior of the chemopreventive agent phenethyl isothiocyanate in rats

2009 ◽  
Vol 54 (3) ◽  
pp. 426-432 ◽  
Author(s):  
Nattaya Konsue ◽  
Jo Kirkpatrick ◽  
Nikolai Kuhnert ◽  
Laurie J. King ◽  
Costas Ioannides
Keyword(s):  
Oral Administration ◽  
Phenethyl Isothiocyanate ◽  
Chemopreventive Agent ◽  
Pharmacokinetic Behavior

Impact of Dilution on the Pharmacokinetic Behavior of Acetaminophen in Rabbits after Oral Administration

1985 ◽  
Vol 74 (3) ◽  
pp. 325-327
Author(s):  
Jacques O. de Beer ◽  
Guido A. Jacobs ◽  
Guido Janssens ◽  
Mark A. Martens
Keyword(s):  
Oral Administration ◽  
Pharmacokinetic Behavior

LC–MS/MS analysis and pharmacokinetics of daidzein and its 7-O-glucuronide in rats after oral administration of 7-O-L-valyl carbamate prodrug

Bioanalysis ◽  
2021 ◽  
Author(s):  
Xiaolan Xu ◽  
Yingchao Li ◽  
Xiaochen Bai ◽  
Farong Lu ◽  
Yawei Zhang ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Oral Administration ◽  
High Throughput ◽  
Matrix Effect ◽  
Water Solubility ◽  
Analytical Procedure ◽  
Extraction Recovery ◽  
Relative Standard ◽  
Sensitive Method ◽  
Pharmacokinetic Behavior

Background: A valine carbamate prodrug (7-P) was designed to enhance the low bioavailability of daidzein due to its low water solubility and membrane permeability. Here, we developed a high-throughput HPLC–MS/MS method to measure daidzein and its 7-O-glucuronide after oral administration of daidzein or 7-P. Materials & methods: A HPLC–MS/MS method was validated and successfully applied to assess the pharmacokinetic behavior of daidzein and its 7-O-glucuronide after orally administrating daidzein or 7-P. The validated method on selectivity, linearity (r ≥ 0.995), precision (relative standard deviation <11.4%), accuracy (relative error <7.1%), extraction recovery (>92.4%), matrix effect (<8.2%) and stability were satisfied. Conclusion: The proposed economical, rapid and sensitive method will be an alternative analytical procedure for daidzein and its metabolite in biological samples.

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