c-jun/AP-1 activation does not affect the antiproliferative activity of phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent

2006 ◽  
Vol 45 (8) ◽  
pp. 605-612 ◽  
Author(s):  
Song Yao ◽  
Yuesheng Zhang ◽  
Jun Li
Keyword(s):  
Antiproliferative Activity ◽  
Phenethyl Isothiocyanate ◽  
Cruciferous Vegetable ◽  
Chemopreventive Agent

scholarly journals Phenethyl Isothiocyanate, a Bioactive Agent for Gastrointestinal Health: A Review

2021 ◽  
Author(s):  
Ezequiel Coscueta ◽  
Ana Sofia Sousa ◽  
Celso Reis ◽  
Manuela Pintado
Keyword(s):  
Gastrointestinal Tract ◽  
Current Knowledge ◽  
Bioactive Compound ◽  
Gastrointestinal Diseases ◽  
Scientific Development ◽  
Therapeutic Effects ◽  
Phenethyl Isothiocyanate ◽  
Cruciferous Vegetable ◽  
Gastrointestinal Health ◽  
Considerable Morbidity

The incidence of gastrointestinal diseases (cancer in particular) has increased progressively with considerable morbidity, mortality, and a high economic impact on the healthcare system. Dietary intake of natural bioactive phytochemicals showed to have cancer-preventing and therapeutic effects. This includes the cruciferous vegetable derivative phenethyl isothiocyanate (PEITC), a bioactive compound from watercress. PEITC antioxidant, anti-inflammatory and anti-cancer properties are of particular importance. This review summarizes the current knowledge on the role of PEITC as a potential natural nutraceutical or an adjuvant against oxidative/inflammatory-related disorders in the gastrointestinal tract. We also discuss the safe and recommended dose of PEITC. Besides, we establish a framework to guide the research and development of sustainable methodologies for obtaining and stabilizing this natural nutraceutical for industrial use. This is a topic that still needs more scientific development, but with the potential to lead to a viable strategy in the prevention of cancer and other associated diseases of the gastrointestinal tract.

Repeated oral administration modulates the pharmacokinetic behavior of the chemopreventive agent phenethyl isothiocyanate in rats

2009 ◽  
Vol 54 (3) ◽  
pp. 426-432 ◽  
Author(s):  
Nattaya Konsue ◽  
Jo Kirkpatrick ◽  
Nikolai Kuhnert ◽  
Laurie J. King ◽  
Costas Ioannides
Keyword(s):  
Oral Administration ◽  
Phenethyl Isothiocyanate ◽  
Chemopreventive Agent ◽  
Pharmacokinetic Behavior

scholarly journals Chemopreventative Potential of the Cruciferous Vegetable Constituent Phenethyl Isothiocyanate in a Mouse Model of Prostate Cancer

2011 ◽  
Vol 103 (7) ◽  
pp. 571-584 ◽  
Author(s):  
Anna A. Powolny ◽  
Ajay Bommareddy ◽  
Eun-Ryeong Hahm ◽  
Daniel P. Normolle ◽  
Jan H. Beumer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mouse Model ◽  
Phenethyl Isothiocyanate ◽  
Cruciferous Vegetable

scholarly journals Antiproliferative Activity of Ethanolic Extract of Ciplukan Herbs (Physalis angulata L.) on 7,12-Dimethylbenz[A]Nthracene-Induced Rat Mammary Carcinogenesis

2011 ◽  
Vol 2 (2) ◽  
pp. 228
Author(s):  
Ameilinda Monikawati ◽  
Sofa Farida ◽  
Laras Widawaty Putri ◽  
Yurista Gilang Ikhtiarsyah ◽  
Edy Meiyanto
Keyword(s):  
Breast Cancer ◽  
Antiproliferative Activity ◽  
Ethanolic Extract ◽  
Control Groups ◽  
Treatment Groups ◽  
Popular Medicine ◽  
Chemopreventive Agent ◽  
Cycle Arrest ◽  
Physalis Angulata ◽  
And Control

Physalis angulata L. is an annual herb widely used as popular medicine for the treatment of cancer. Physalis angulata L. ethanolic extract (PEE) has been demonstrated to have strong cytotoxic activity against breast cancer, inhibited cancer cell’s proliferation and induced cell cycle arrest. The aim of our study is to investigate the effect of PEE as a cancer chemopreventive agent on 7,12-dimethylbenz[a]nthracene (DMBA)-induced rats mammary. The antiproliferative activity was characterized by monitoring the histopatology representation and expression of cell proliferation on DMBA-induced mammary rats that were treated with PEE against control groups. The histopatology representation were analyzed by Haematoksilin Eosin (HE) staining method, while proliferative activity was detected by AgNOR method. The HE staining results showed significant differences in cells morphology of treatment groups compared to the control groups. Thus results suggest that PEE was able to repair morphology of cells undergoing carcinogenesis. AgNOR method showed decreasing occurrence of black dots between treatment and control groups. Thus, we conclude that PEE has an antiproliferative activity on DMBA-induced rat mammary. Therefore, the ethanolic extract of Physalis angulata herbs is a potential chemopreventive agent on cancer. Further study on its molecular mechanism needs to be explored.Keywords: Physalis angulata, breast cancer, 7,12-dimethylbenz[a]nthracene, carcinogenesis, antiproliferative

Abstract 1629: Restoration of the wild type function to mutant p53 by chemopreventive agent phenethyl isothiocyanate

2010 ◽  
Author(s):  
Xiantao Wang ◽  
Sudha Govind ◽  
Jessie Yu-Chieh Wu ◽  
York Tomita ◽  
Lixin Mi ◽  
...  
Keyword(s):  
Mutant P53 ◽  
Phenethyl Isothiocyanate ◽  
Wild Type ◽  
Type Function ◽  
Chemopreventive Agent
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