Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2)

Molecular Nutrition & Food Research ◽

10.1002/mnfr.201400288 ◽

2014 ◽

Vol 58 (11) ◽

pp. 2099-2110 ◽

Author(s):

Kee W. Tan ◽

Janine Cooney ◽

Dwayne Jensen ◽

Yan Li ◽

James W. Paxton ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Resistance Protein ◽

Efflux Transporter ◽

Cancer Resistance ◽

Resistance Protein

Download Full-text

Role of breast cancer resistance protein (BCRP) as active efflux transporter on blood-brain barrier (BBB) permeability

Molecular Diversity ◽

10.1007/s11030-014-9562-2 ◽

2014 ◽

Vol 19 (1) ◽

pp. 163-172 ◽

Author(s):

Prabha Garg ◽

Rahul Dhakne ◽

Vilas Belekar

Keyword(s):

Breast Cancer ◽

Blood Brain Barrier ◽

Breast Cancer Resistance Protein ◽

Brain Barrier ◽

Efflux Transporter ◽

Cancer Resistance ◽

Active Efflux ◽

Blood Brain ◽

Resistance Protein

Download Full-text

Efflux transporter breast cancer resistance protein dominantly expresses on the membrane of red blood cells, hinders partitioning of its substrates into the cells, and alters drug–drug interaction profiles

Xenobiotica ◽

10.1080/00498254.2017.1397812 ◽

2017 ◽

Vol 48 (11) ◽

pp. 1173-1183 ◽

Author(s):

Pu Shi ◽

Mingxiang Liao ◽

Bei-Ching Chuang ◽

Robert Griffin ◽

Judy Shi ◽

...

Keyword(s):

Breast Cancer ◽

Drug Interaction ◽

Red Blood Cells ◽

Blood Cells ◽

Breast Cancer Resistance Protein ◽

Efflux Transporter ◽

Cancer Resistance ◽

Resistance Protein ◽

Drug Drug Interaction

Download Full-text

Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2)

Food Chemistry ◽

10.1016/j.foodchem.2012.12.021 ◽

2013 ◽

Vol 138 (4) ◽

pp. 2267-2274 ◽

Author(s):

Kee W. Tan ◽

Yan Li ◽

James W. Paxton ◽

Nigel P. Birch ◽

Arjan Scheepens

Keyword(s):

Breast Cancer ◽

Breast Cancer Resistance Protein ◽

Efflux Transporter ◽

Cancer Resistance ◽

Dietary Phytochemicals ◽

Resistance Protein

Download Full-text

Improvement of the Oral Drug Absorption of Topotecan through the Inhibition of Intestinal Xenobiotic Efflux Transporter, Breast Cancer Resistance Protein, by Excipients

Drug Metabolism and Disposition ◽

10.1124/dmd.106.014217 ◽

2007 ◽

Vol 35 (7) ◽

pp. 1142-1148 ◽

Author(s):

Tetsuo Yamagata ◽

Hiroyuki Kusuhara ◽

Mariko Morishita ◽

Kozo Takayama ◽

Hassan Benameur ◽

...

Keyword(s):

Breast Cancer ◽

Drug Absorption ◽

Breast Cancer Resistance Protein ◽

Oral Drug ◽

Efflux Transporter ◽

Cancer Resistance ◽

Oral Drug Absorption ◽

Resistance Protein

Download Full-text

The Gut Microbiota Ellagic Acid-Derived Metabolite Urolithin A and Its Sulfate Conjugate Are Substrates for the Drug Efflux Transporter Breast Cancer Resistance Protein (ABCG2/BCRP)

Journal of Agricultural and Food Chemistry ◽

10.1021/jf4007505 ◽

2013 ◽

Vol 61 (18) ◽

pp. 4352-4359 ◽

Author(s):

Antonio González-Sarrías ◽

Verónica Miguel ◽

Gracia Merino ◽

Ricardo Lucas ◽

Juan C. Morales ◽

...

Keyword(s):

Breast Cancer ◽

Gut Microbiota ◽

Ellagic Acid ◽

Breast Cancer Resistance Protein ◽

Drug Efflux ◽

Efflux Transporter ◽

Cancer Resistance ◽

Urolithin A ◽

Resistance Protein ◽

Sulfate Conjugate

Download Full-text

Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure

Drug Metabolism and Disposition ◽

10.1124/dmd.115.066795 ◽

2015 ◽

Vol 44 (3) ◽

pp. 398-408 ◽

Author(s):

R. Elsby ◽

P. Martin ◽

D. Surry ◽

P. Sharma ◽

K. Fenner

Keyword(s):

Breast Cancer ◽

Drug Interaction ◽

Breast Cancer Resistance Protein ◽

Fold Increase ◽

Efflux Transporter ◽

Cancer Resistance ◽

Resistance Protein ◽

Drug Drug Interaction ◽

Clinically Significant

Download Full-text

Faculty Opinions recommendation of The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13353972.14725070 ◽

2011 ◽

Author(s):

Susan Bates

Keyword(s):

Breast Cancer ◽

Proximal Tubule ◽

Breast Cancer Resistance Protein ◽

Apical Membrane ◽

Human Kidney ◽

Cancer Resistance ◽

Kidney Proximal Tubule ◽

Resistance Protein

Download Full-text

Faculty Opinions recommendation of Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3171959.2859057 ◽

2010 ◽

Author(s):

Susan Bates

Keyword(s):

Breast Cancer ◽

Breast Cancer Resistance Protein ◽

Cancer Resistance ◽

Active Efflux ◽

P Glycoprotein ◽

Resistance Protein ◽

Download Full-text

Faculty Opinions recommendation of Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2).

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725783242.793517907 ◽

2016 ◽

Author(s):

Susan Bates

Keyword(s):

Breast Cancer ◽

Breast Cancer Resistance Protein ◽

Cancer Resistance ◽

Glycoprotein P ◽

Alk Inhibitor ◽

P Glycoprotein ◽

Resistance Protein

Download Full-text

Faculty of 1000 evaluation for The "specific" P-glycoprotein inhibitor tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2).

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.9419956.10057054 ◽

2011 ◽

Author(s):

Robert Fecik

Keyword(s):

Breast Cancer ◽

Breast Cancer Resistance Protein ◽

Cancer Resistance ◽

P Glycoprotein ◽

Resistance Protein

Download Full-text