scholarly journals Optimization of phase‐contrast MRI for the estimation of global cerebral blood flow of mice at 11.7T

2018 ◽  
Vol 81 (4) ◽  
pp. 2566-2575 ◽  
Author(s):  
Zhiliang Wei ◽  
Lin Chen ◽  
Zixuan Lin ◽  
Dengrong Jiang ◽  
Jiadi Xu ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Phase Contrast ◽  
Phase Contrast Mri ◽  
Global Cerebral Blood Flow

scholarly journals Automatic and Reproducible Positioning of Phase-Contrast MRI for the Quantification of Global Cerebral Blood Flow

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e95721 ◽  
Author(s):  
Peiying Liu ◽  
Hanzhang Lu ◽  
Francesca M. Filbey ◽  
Amy E. Pinkham ◽  
Carrie J. McAdams ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Phase Contrast ◽  
Phase Contrast Mri ◽  
Global Cerebral Blood Flow

scholarly journals Phase contrast mapping MRI measurements of global cerebral blood flow across different perfusion states – A direct comparison with 15O-H2O positron emission tomography using a hybrid PET/MR system

2018 ◽  
Vol 39 (12) ◽  
pp. 2368-2378 ◽  
Author(s):  
Oriol Puig ◽  
Mark B Vestergaard ◽  
Ulrich Lindberg ◽  
Adam E Hansen ◽  
Annette Ulrich ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Strong Correlation ◽  
Phase Contrast ◽  
Young Male ◽  
Emission Tomography ◽  
Easy Access ◽  
Positron Emission ◽  
Global Cerebral Blood Flow

Phase-contrast mapping (PCM) magnetic resonance imaging (MRI) provides easy-access non-invasive quantification of global cerebral blood flow (gCBF) but its accuracy in altered perfusion states is not established. We aimed to compare paired PCM MRI and 15O-H2O positron emission tomography (PET) measurements of gCBF in different perfusion states in a single scanning session. Duplicate combined gCBF PCM-MRI and 15O-H2O PET measurements were performed in the resting condition, during hyperventilation and after acetazolamide administration (post-ACZ) using a 3T hybrid PET/MR system. A total of 62 paired gCBF measurements were acquired in 14 healthy young male volunteers. Average gCBF in resting state measured by PCM-MRI and 15O-H2O PET were 58.5 ± 10.7 and 38.6 ± 5.7 mL/100 g/min, respectively, during hyperventilation 33 ± 8.6 and 24.7 ± 5.8 mL/100 g/min, respectively, and post-ACZ 89.6 ± 27.1 and 57.3 ± 9.6 mL/100 g/min, respectively. On average, gCBF measured by PCM-MRI was 49% higher compared to 15O-H2O PET. A strong correlation between the two methods across all states was observed (R2 = 0.72, p < 0.001). Bland–Altman analysis suggested a perfusion dependent relative bias resulting in higher relative difference at higher CBF values. In conclusion, measurements of gCBF by PCM-MRI in healthy volunteers show a strong correlation with 15O-H2O PET, but are associated with a large and non-linear perfusion-dependent difference.

IC-P-108: Cerebral Blood Flow Measured With Phase-Contrast MRI in AD, MCI and Controls

2016 ◽  
Vol 12 ◽  
pp. P82-P82
Author(s):  
Jolien F. Leijenaar ◽  
Ingrid S. van Maurik ◽  
Joost Kuijer ◽  
Wiesje M. van der Flier ◽  
Philip Scheltens ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Phase Contrast ◽  
Phase Contrast Mri

scholarly journals Comparison of global cerebral blood flow measured by phase-contrast mapping MRI with 15 O-H2 O positron emission tomography

2016 ◽  
Vol 45 (3) ◽  
pp. 692-699 ◽  
Author(s):  
Mark Bitsch Vestergaard ◽  
Ulrich Lindberg ◽  
Niels Jacob Aachmann-Andersen ◽  
Kristian Lisbjerg ◽  
Søren Just Christensen ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Phase Contrast ◽  
Emission Tomography ◽  
Positron Emission ◽  
Global Cerebral Blood Flow

scholarly journals Simultaneous phase‐contrast MRI and PET for noninvasive quantification of cerebral blood flow and reactivity in healthy subjects and patients with cerebrovascular disease

2019 ◽  
Vol 51 (1) ◽  
pp. 183-194 ◽  
Author(s):  
Yosuke Ishii ◽  
Thoralf Thamm ◽  
Jia Guo ◽  
Mohammad Mehdi Khalighi ◽  
Mirwais Wardak ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebrovascular Disease ◽  
Healthy Subjects ◽  
Phase Contrast ◽  
Phase Contrast Mri

Reduced Cerebral Blood Flow in Mild Cognitive Impairment Assessed Using Phase-Contrast MRI

2017 ◽  
Vol 58 (2) ◽  
pp. 585-595 ◽  
Author(s):  
Reyes García de Eulate ◽  
Irene Goñi ◽  
Alvaro Galiano ◽  
Marta Vidorreta ◽  
Miriam Recio ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Phase Contrast ◽  
Phase Contrast Mri

scholarly journals Comparison of non-invasive MRI measurements of cerebral blood flow in a large multisite cohort

2016 ◽  
Vol 36 (7) ◽  
pp. 1244-1256 ◽  
Author(s):  
Sudipto Dolui ◽  
Ze Wang ◽  
Danny JJ Wang ◽  
Raghav Mattay ◽  
Mack Finkel ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Phase Contrast ◽  
Spin Labeling ◽  
Flow Measurements ◽  
Entire Cohort ◽  
Non Invasive ◽  
Global Cerebral Blood Flow ◽  
Continuous Arterial Spin Labeling

Arterial spin labeling and phase contrast magnetic resonance imaging provide independent non-invasive methods for measuring cerebral blood flow. We compared global cerebral blood flow measurements obtained using pseudo-continuous arterial spin labeling and phase contrast in 436 middle-aged subjects acquired at two sites in the NHLBI CARDIA multisite study. Cerebral blood flow measured by phase contrast (CBFPC: 55.76 ± 12.05 ml/100 g/min) was systematically higher ( p < 0.001) and more variable than cerebral blood flow measured by pseudo-continuous arterial spin labeling (CBFPCASL: 47.70 ± 9.75). The correlation between global cerebral blood flow values obtained from the two modalities was 0.59 ( p < 0.001), explaining less than half of the observed variance in cerebral blood flow estimates. Well-established correlations of global cerebral blood flow with age and sex were similarly observed in both CBFPCASL and CBFPC. CBFPC also demonstrated statistically significant site differences, whereas no such differences were observed in CBFPCASL. No consistent velocity-dependent effects on pseudo-continuous arterial spin labeling were observed, suggesting that pseudo-continuous labeling efficiency does not vary substantially across typical adult carotid and vertebral velocities, as has previously been suggested. Conclusions: Although CBFPCASL and CBFPC values show substantial similarity across the entire cohort, these data do not support calibration of CBFPCASL using CBFPC in individual subjects. The wide-ranging cerebral blood flow values obtained by both methods suggest that cerebral blood flow values are highly variable in the general population.

Assessment of cerebral blood flow in neonates and infants: A phase-contrast MRI study

NeuroImage ◽  
2019 ◽  
Vol 185 ◽  
pp. 926-933 ◽  
Author(s):  
Peiying Liu ◽  
Ying Qi ◽  
Zixuan Lin ◽  
Qiyong Guo ◽  
Xiaoming Wang ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Phase Contrast ◽  
Phase Contrast Mri ◽  
Mri Study ◽  
Neonates And Infants
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