Insights into tissue microstructure using a double diffusion encoding sequence on a clinical scanner: Validation and application to experimental tumor models

2019 ◽  
Vol 83 (4) ◽  
pp. 1263-1276 ◽  
Author(s):  
Gaëtan Duchêne ◽  
Jorge Abarca‐Quinones ◽  
Isabelle Leclercq ◽  
Thierry Duprez ◽  
Frank Peeters
Keyword(s):  
Double Diffusion ◽  
Tumor Models ◽  
Experimental Tumor ◽  
Tissue Microstructure ◽  
Clinical Scanner

scholarly journals Immunomodulatory effects of soluble CD5 on experimental tumor models

Oncotarget ◽  
2017 ◽  
Vol 8 (64) ◽  
pp. 108156-108169 ◽  
Author(s):  
Inês T. Simões ◽  
Fernando Aranda ◽  
Esther Carreras ◽  
Maria Velasco-de Andrés ◽  
Sergi Casadó-Llombart ◽  
...  
Keyword(s):  
Immunomodulatory Effects ◽  
Tumor Models ◽  
Experimental Tumor

Modulation of multidrug resistance in experimental tumor models with dexverapamil and MS-209

1994 ◽  
Vol 5 ◽  
pp. 37
Author(s):  
D Butler ◽  
C Maher ◽  
S Wardwell ◽  
C A Romerdahl
Keyword(s):  
Multidrug Resistance ◽  
Tumor Models ◽  
Experimental Tumor

scholarly journals 3′-Deoxy-3′-[18F]Fluorothymidine Uptake Is Related to Thymidine Phosphorylase Expression in Various Experimental Tumor Models

2017 ◽  
Vol 20 (2) ◽  
pp. 194-199 ◽  
Author(s):  
Sonja Schelhaas ◽  
Kathrin Heinzmann ◽  
Davina J. Honess ◽  
Donna-Michelle Smith ◽  
Heather Keen ◽  
...  
Keyword(s):  
Thymidine Phosphorylase ◽  
Tumor Models ◽  
Experimental Tumor ◽  
Thymidine Phosphorylase Expression

scholarly journals Axon Diameters and Myelin Content Modulate Microscopic Fractional Anisotropy at Short Diffusion Times in Fixed Rat Spinal Cord

2018 ◽  
Vol 6 ◽  
Author(s):  
Noam Shemesh
Keyword(s):  
Spinal Cord ◽  
Fractional Anisotropy ◽  
Double Diffusion ◽  
Orientation Distribution ◽  
Axon Diameter ◽  
Rat Spinal Cord ◽  
Tissue Microstructure ◽  
Water Fraction ◽  
Path Lengths ◽  
Magnetic Resonance Imaging Mri

Mapping tissue microstructure accurately and noninvasively is one of the frontiers of biomedical imaging. Diffusion Magnetic Resonance Imaging (MRI) is at the forefront of such efforts, as it is capable of reporting on microscopic structures orders of magnitude smaller than the voxel size by probing restricted diffusion. Double Diffusion Encoding (DDE) and Double Oscillating Diffusion Encoding (DODE) in particular, are highly promising for their ability to report on microscopic fractional anisotropy (μFA), a measure of the pore anisotropy in its own eigenframe, irrespective of orientation distribution. However, the underlying correlates of μFA have insofar not been studied. Here, we extract μFA from DDE and DODE measurements at ultrahigh magnetic field of 16.4T with the goal of probing fixed rat spinal cord microstructure. We further endeavor to correlate μFA with Myelin Water Fraction (MWF) derived from multiexponential T2 relaxometry, as well as with literature-based spatially varying axon diameter. In addition, a simple new method is presented for extracting unbiased μFA from three measurements at different b-values. Our findings reveal strong anticorrelations between μFA (derived from DODE) and axon diameter in the distinct spinal cord tracts; a moderate correlation was also observed between μFA derived from DODE and MWF. These findings suggest that axonal membranes strongly modulate μFA, which—owing to its robustness toward orientation dispersion effects—reflects axon diameter much better than its typical FA counterpart. μFA varied when measured via oscillating or blocked gradients, suggesting selective probing of different parallel path lengths and providing insight into how those modulate μFA metrics. Our findings thus shed light into the underlying microstructural correlates of μFA and are promising for future interpretations of this metric in health and disease.

The Comparative Study of Antitumor Activity and Safety of the Novel Protein-targeted Actinomycin Drugs Delivery in Experimental Tumor Models of Mice.

2016 ◽  
Vol 3 (3) ◽  
pp. 188-199 ◽  
Author(s):  
B. I. Kruglyi ◽  
E. D. Nikolskaya ◽  
E. S. Severin ◽  
G. G. Barsegyan ◽  
N. G. Yabbarov ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Comparative Study ◽  
The Novel ◽  
Tumor Models ◽  
Experimental Tumor ◽  
The Comparative Study ◽  
Novel Protein

Antitumor activity and low intestinal toxicity of S-1, a new formulation of oral tegafur, in experimental tumor models in rats

1996 ◽  
Vol 39 (3) ◽  
pp. 205-211 ◽  
Author(s):  
T. Takechi ◽  
Koushi Nakano ◽  
Junji Uchida ◽  
Akira Mita ◽  
Kisako Toko ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tumor Models ◽  
Experimental Tumor ◽  
Intestinal Toxicity ◽  
New Formulation
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