scholarly journals Suprachiasmatic Nucleus–Arcuate Nucleus Axis: Interaction Between Time and Metabolism Essential for Health

Obesity ◽  
2020 ◽  
Vol 28 (S1) ◽  
Author(s):  
Rebeca Méndez‐Hernández ◽  
Carolina Escobar ◽  
Ruud M. Buijs
Keyword(s):  
Suprachiasmatic Nucleus ◽  
Arcuate Nucleus

scholarly journals Suprachiasmatic nucleus-mediated glucose entry into the arcuate nucleus determines the daily rhythm in blood glycemia

2022 ◽  
Author(s):  
Betty Rodríguez-Cortés ◽  
Gabriela Hurtado-Alvarado ◽  
Ricardo Martínez-Gómez ◽  
Luis A. León-Mercado ◽  
Masha Prager-Khoutorsky ◽  
...  
Keyword(s):  
Suprachiasmatic Nucleus ◽  
Arcuate Nucleus ◽  
Daily Rhythm

scholarly journals The Suprachiasmatic Nucleus Modulates the Sensitivity of Arcuate Nucleus to Hypoglycemia in the Male Rat

Endocrinology ◽  
2016 ◽  
Vol 157 (9) ◽  
pp. 3439-3451 ◽  
Author(s):  
D. Herrera-Moro Chao ◽  
L. León-Mercado ◽  
E. Foppen ◽  
M. Guzmán-Ruiz ◽  
M. C. Basualdo ◽  
...  
Keyword(s):  
Suprachiasmatic Nucleus ◽  
Neuronal Activity ◽  
Arcuate Nucleus ◽  
Light Period ◽  
Male Rat ◽  
Glucose Response ◽  
Glucose Levels ◽  
Metabolic Conditions ◽  
Surrounding Areas ◽  
Metabolic Information

The suprachiasmatic nucleus (SCN) and arcuate nucleus (ARC) have reciprocal connections; catabolic metabolic information activates the ARC and inhibits SCN neuronal activity. Little is known about the influence of the SCN on the ARC. Here, we investigated whether the SCN modulated the sensitivity of the ARC to catabolic metabolic conditions. ARC neuronal activity, as determined by c-Fos immunoreactivity, was increased after a hypoglycemic stimulus by 2-deoxyglucose (2DG). The highest ARC neuronal activity after 2DG was found at the end of the light period (zeitgeber 11, ZT11) with a lower activity in the beginning of the light period (zeitgeber 2, ZT2), suggesting the involvement of the SCN. The higher activation of ARC neurons after 2DG at ZT11 was associated with higher 2DG induced blood glucose levels as compared with ZT2. Unilateral SCN-lesioned animals, gave a mainly ipsilateral activation of ARC neurons at the lesioned side, suggesting an inhibitory role of the SCN on ARC neurons. The 2DG-induced counterregulatory glucose response correlated with increased ARC neuronal activity and was significantly higher in unilateral SCN-lesioned animals. Finally, the ARC as site where 2DG may, at least partly, induce a counterregulatory response was confirmed by local microdialysis of 2DG. 2DG administration in the ARC produced a higher increase in circulating glucose compared with 2DG administration in surrounding areas such as the ventromedial nucleus of the hypothalamus (VMH). We conclude that the SCN uses neuronal pathways to the ARC to gate sensory metabolic information to the brain, regulating ARC glucose sensitivity and counterregulatory responses to hypoglycemic conditions.

scholarly journals The Suprachiasmatic Nucleus Changes the Daily Activity of the Arcuate Nucleus α-MSH Neurons in Male Rats

Endocrinology ◽  
2014 ◽  
Vol 155 (2) ◽  
pp. 525-535 ◽  
Author(s):  
M. Guzmán-Ruiz ◽  
N. Saderi ◽  
F. Cazarez-Márquez ◽  
N. N. Guerrero-Vargas ◽  
M. C. Basualdo ◽  
...  
Keyword(s):  
Suprachiasmatic Nucleus ◽  
Daily Activity ◽  
Arcuate Nucleus ◽  
Male Rats

scholarly journals Suprachiasmatic Nucleus Interaction with the Arcuate Nucleus; Essential for Organizing Physiological Rhythms

eNeuro ◽  
2017 ◽  
Vol 4 (2) ◽  
pp. ENEURO.0028-17.2017 ◽  
Author(s):  
Frederik N. Buijs ◽  
Mara Guzmán-Ruiz ◽  
Luis León-Mercado ◽  
Mari Carmen Basualdo ◽  
Carolina Escobar ◽  
...  
Keyword(s):  
Suprachiasmatic Nucleus ◽  
Arcuate Nucleus ◽  
Nucleus Interaction

scholarly journals Ventromedial Arcuate Nucleus Communicates Peripheral Metabolic Information to the Suprachiasmatic Nucleus

Endocrinology ◽  
2006 ◽  
Vol 147 (1) ◽  
pp. 283-294 ◽  
Author(s):  
Chun-Xia Yi ◽  
Jan van der Vliet ◽  
Jiapei Dai ◽  
Guangfu Yin ◽  
Liqiang Ru ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Suprachiasmatic Nucleus ◽  
Energy Homeostasis ◽  
Arcuate Nucleus ◽  
Circumventricular Organs ◽  
Systemic Injection ◽  
Neural Connections ◽  
The Central Nervous System ◽  
Functional Pathway

The arcuate nucleus (ARC) is crucial for the maintenance of energy homeostasis as an integrator of long- and short-term hunger and satiety signals. The expression of receptors for metabolic hormones, such as insulin, leptin, and ghrelin, allows ARC to sense information from the periphery and signal it to the central nervous system. The ventromedial ARC (vmARC) mainly comprises orexigenic neuropeptide agouti-related peptide and neuropeptide Y neurons, which are sensitive to circulating signals. To investigate neural connections of vmARC within the central nervous system, we injected the neuronal tracer cholera toxin B into vmARC. Due to variation of injection sites, tracer was also injected into the subependymal layer of the median eminence (seME), which showed similar projection patterns as the vmARC. We propose that the vmARC forms a complex with the seME, their reciprocal connections with viscerosensory areas in brain stem, and other circumventricular organs, suggesting the exchange of metabolic and circulating information. For the first time, the vmARC-seME was shown to have reciprocal interaction with the suprachiasmatic nucleus (SCN). Activation of vmARC neurons by systemic administration of the ghrelin mimetic GH-releasing peptide-6 combined with SCN tracing showed vmARC neurons to transmit feeding related signals to the SCN. The functionality of this pathway was demonstrated by systemic injection of GH-releasing peptide-6, which induced Fos in the vmARC and resulted in a reduction of about 40% of early daytime Fos immunoreactivity in the SCN. This observation suggests an anatomical and functional pathway for peripheral hormonal feedback to the hypothalamus, which may serve to modulate the activity of the SCN.

Ultrastructural Localization of Acetylcholinesterase in the Arcuate Nucleus and Median Eminence of the Rat

1977 ◽  
Vol 35 ◽  
pp. 440-441
Author(s):  
K.A. Carson ◽  
C.B. Nemeroff ◽  
M.S. Rone ◽  
J.S. Kizer ◽  
J.S. Hanker
Keyword(s):  
Choline Acetyltransferase ◽  
Median Eminence ◽  
Arcuate Nucleus ◽  
Cholinergic Neurons ◽  
Ultrastructural Localization ◽  
Male Rats ◽  
Neonatal Rats ◽  
Good Marker ◽  
Chemical Studies ◽  
High Doses

Biochemical, physiological, pharmacological, and more recently enzyme histo- chemical data have indicated that cholinergic circuits exist in the hypothalamus. Ultrastructural correlates of these pathways such as acetylcholinesterase (AchE) positive neurons in the arcuate nucleus (ARC) and stained terminals in the median eminence (ME) have yet to be described. Initial studies in our laboratories utilizing chemical lesioning and microdissection techniques coupled with microchemical and light microscopic enzyme histo- chemical studies suggested the existence of cholinergic neurons in the ARC which project to the ME (1). Furthermore, in adult male rats with Halasz deafferentations (hypothalamic islands composed primarily of the isolated ARC and the ME) choline acetyltransferase (ChAc) activity, a good marker for cholinergic neurons, was not significantly reduced in the ME and was only somewhat reduced in the ARC (2). Treatment of neonatal rats with high doses of monosodium 1-glutamate (MSG) results in a lesion largely restricted to the neurons of the ARC.

The characterization of sleep--wake pattern and its association with melatonin, as a marker of the circadian function of the suprachiasmatic nucleus, in craniopharyngioma patients

2013 ◽  
Author(s):  
Line Pickering Jakobsen ◽  
Poul Jennum ◽  
Steen Gammeltoft ◽  
Ulla Feldt-Rasmussen ◽  
Marianne Klose
Keyword(s):  
Suprachiasmatic Nucleus
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